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Start Over Descriptor "Linkage (Genetics) -- Usage" Journal proceedings of the national academy of sciences of the united states
1 results on '"Linkage (Genetics) -- Usage"'

1. Susceptibilty of renal carcinoma in the Eker rat involves a tumor suppressor gene on chromosome 10

Author

Yeung, Raymond S., Buetow, Kanneth H., Testa, Joseph R., and Knudson, Alfred G., Jr.

Subjects
Carcinoma, Renal cell -- Analysis, Linkage (Genetics) -- Usage, Science and technology
Abstract

The locus of the inherited renal carcinoma (RC) mutation was mapped to rat chromosomal band near the protamine locus, using linkage studies, which reveal tumors loss homology at this locus indicating that this putative tumor suppressor gene is recessive. The human homology of the RC gene could be present on human chromosome 16, not believed to be changed ordinarily in human RC. In the rat, a type of primarily inherited RC causes multiple chromophobe cell tumors, similar to the human disease, and heterozygous carriers are very vulnerable to radiation and chemical carcinogens.

Published
1993

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