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The sustainable development is a concept of great importance today, defined by several dimensions, such as referring to the fulfillment of human interests, the environment created aimed at matching the natural man, but by the social. The definition and its practical implementation must take into account more factors and the specific principles. From the economic perspective, economic policy must integrate the ecological principles that ensure its successful development to be sustainable in the long term. This paper presents the case of economic and ecological approach in territorial that is about developing the South-Muntenia Region of Romania. With a total surface of 34,453 km² (14.54% of the total area of Romania), the South-Muntenia Region [3] consists of seven counties (Argeş, Călăraşi, Dâmboviţa, Giurgiu, Ialomiţa, Prahova and Teleorman). The relief of the Region 3 South-Muntenia is characterized by variety, the difference in level is over 2400m allocated in proportion, stepped down from north to south of the Făgăraş and Bucegi mountains and ridges to the Danube Valley, which leads to the types of mountain, hill and plain climate. Like all developing regions of our country, in the South-Muntenia Region also are made efforts to attain the sustainable development objectives. The situation of the region is studied through analysis of the economic indicators and environmental development. [ABSTRACT FROM AUTHOR]