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The TYPHOON program is producing an atlas of spectroscopic data cubes of 44 large-angular-sized galaxies with complete spatial coverage from 3650–9000 Å. This survey provides an unparalleled opportunity to study variations in the interstellar medium (ISM) properties within individual H ii regions across the entire star-forming disks of nearby galaxies. This can provide key insights into the spatial distribution and resolved properties of the ISM to understand how efficiently metals are mixed and redistributed across spirals and dwarf galaxies. In this Proceeding, we present early science results from six nearby spiral galaxies as part of the TYPHOON program from Grasha et al. (2022). We use HIIPhot to identify the H ii regions within the galaxy based on the surface brightness of the Hα emisison line and measure variations of the H ii region oxygen abundance. In this initial work, we find that while the spiral pattern plays a role in organizing the ISM, it alone does not establish the relatively uniform azimuthal variations we observe across all the galaxies. Differences in the metal abundances are more likely driven by the strong correlations with the local physical conditions. We find a strong and positive correlation between the ionization parameter and the local abundances as measured by the relative metallicity offset Δ(O/H), indicating a tight relationship between local physical conditions and their localized enrichment of the ISM. These variations can be explained by a combination of localized, star formation-driven self-enrichment and large-scale mixing-driven dilution due to the passing of spiral density waves. [ABSTRACT FROM AUTHOR]

Star formation provides insight into the physical processes that govern the transformation of gas into stars. A key missing piece in a predictive theory of star formation is the link between scales of individual stars and star clusters up to entire galaxies. LEGUS is now providing the information to test the overall organization and spatial evolution of star formation. We present our latest findings of using star clusters from LEGUS combined with ALMA CO observations to investigate the transition from molecular gas to star formation in local galaxies. This work paves the way for future JWST observations of the embedded phase of star formation, the last missing ingredient to connect young star clusters and their relation with gas reservoirs. Multi-wavelength studies of local galaxies and their stellar and gas components will help shed light on early phases of galaxy evolution and properties of the ISM at high-z. [ABSTRACT FROM AUTHOR]