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Abstract: Advanced additive manufacturing technologies, namely Biomanufacturing, are being used to fabricate scaffolds with controlled architecture for tissue engineering applications. These technologies combined with computer-aided design (CAD) enable to produce three-dimensional structures layer-by-layer in a multitude of materials. Actual prediction of the effective mechanical properties of scaffolds produced by Biomanufacturing, is very important for tissue engineering applications. A novel computer based technique for scaffold design is topological optimisation. Topological optimisation is a form of “shape” optimisation, usually referred to as “layout” optimisation. The goal of topological optimisation is to find the best use of material for a body that is subjected to either a single load or a multiple load distribution. This paper proposes a topological optimisation scheme in order to obtain the ideal topological architectures of scaffolds, maximising its mechanical behaviour. [Copyright &y& Elsevier]