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The efficacy of a combined use of isoniazid together with polyzid prolonged tuberculostatic and tricarboxylic acid cycle metabolites was experimentally studied in guinea pigs. Mortality rates, pathomorphologic test data and the extent of tuberculous affection in the animals confirm a fairly high efficacy of prolonged polyzid in combination with succinate and malate as pathogenetic drugs.

A procedure of polychromatic analysis (PA) was improved by using light filter occular attachments. In 154 patients, including those with pulmonary tuberculosis (101) and sarcoidosis (53), a diagnostic effectiveness of a traditional bronchoscopy is compared to that with PA, including morphoendoscopic comparison. As against traditional bronchoscopy, PA made it possible to find out in 34.8% an additional number of non-specific endobronchitis cases accompanying pulmonary tuberculosis, and at the same time to approach in 90.2% an endoscopic diagnosis to a pathomorphologic one. In several patients the authors managed to additionally distinguish by means of PA infiltrative bronchial tuberculosis of tuberous type. In pulmonary sarcoidosis the use of PA also allowed to increase a diagnostic effectiveness of the traditional bronchoscopy.

The time course of tuberculin reactions during isoniazid treatment was studied on 10 guinea pigs with experimental tuberculosis. Linear, temperature and histological characteristics of papules were investigated. Thermographic estimation of papules was performed with cholesteric liquid crystal films. For pathohistological examination a new histochemical method developed at the Kiev Research Institute of Phthisiology and pulmonology on the basis of trimethine dyes of the oxanol class of organic solvents (with PK-144) was used along with the routine procedures. A decrease in the temperature gradient (difference of temperatures over papules and the symmetric areas of the skin on the other side of the animal body) was stated irrespective of the papule linear size. The thermographic method for estimating tuberculin reactions based on pathophysiological processes in papules during isoniazid treatment for 2.5 months proved to be a finer procedure for evaluating tuberculin papules than measuring their linear size.