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Purpose. The aim of this study was to evaluate the efficacy of nitrofurantoin and cotrimoxazole in the treatment of recurrent, uncomplicated lower urinary tract infections (RUTIs) in type 2 diabetic women. Materials and methods. Including criteria were as followed: post-menopaused females aged 50-70 years with type 2 diabetes. All patients suffered from RUTIs, presented now clinical signs of this disease and positive urine culture (isolated bacterial uropathogen sensitive to nitrofurantoin and cotrimoxazole). The study comprised 100 type 2 diabetic women, which were divided into two similar numerical groups. Group 1 was treated with nitrofurantoin and group 2 with cotrimoxazole. The patients remained under regular medical supervision in diabetic outpatient clinic. For 12 months patients were treated with antimicrobial agents. Then for 3 months lasted observation period, in which patients didn't taken antibacterial agents. Efficacy of treatment was estimated when both clinical cure and bacteriological eradication of uropathogens were achieved in specified studied time points (3, 6, 12 and 15 months from the study beginning). Results. The percentage of patients effectively treated for three, six and twelve months did not differ significantly the studied groups (p > 0.05). The percentage of patients without sign of RUTIs didn't differ the groups 3 months after antibacterial treatment discontinuation (p > 0.05). Conclusions. Nitrofurantoin and cotrimoxazole are the effective drugs to treat the recurrent uncomplicated lower urinary tract infections in type 2 diabetic patients. [ABSTRACT FROM AUTHOR]

Background: Ambulatory 24h - blood pressure measurement (ABPM) provides to assess exactly daily this parameter. According to World Health Organisation, ABPM is particularly helpful in patients with essential fluctuation of blood pressure during clinic visit, in patients with hipotonia and with antihypertensive drug-resistant arterial hypertension. ABPM is the best method useful in diagnosis of „white coat hypertension". Aim: The aim of the study was evaluation of frequency of various forms of arterial hypertension in type 2 diabetic patients with overweight detected with the use of ABPM. Material and method: The study comprised of subjects at the age 40-70 years. Group 1 (n=87) comprised of type 2 diabetic patients and the control group 2 (n=80) constitited patients without diabetes. During outpatient clinic visit 24h - ABPM was conducted. Occurrence of isolated systolic arterial hypertension, isolated diastolic hypertension and systolic-diastolic hypertension in two studied groups were diagnosed. Results. In 80% of type 2 diabetic patients (70 subjects) and in 64% of patients without diabetes arterial hypertension (51 subjects) was diagnosed. This parameter differed essential study groups (p=0.02). In half of all studied patients with de novo detected hypertension systolic - diastolic arterial hypertension was examined (35 subjects). In above 2/5 of these patients isolated systolic hypertension was examined. The higher percentage of patients with isolated systolic hypertension in type 2 diabetic patients was observed in comparison with control group (p=0.02). The higher percentage of patients with systolic-diastolic arterial hypertension in group 1 was observed than in the second group (p=0.03). The percentage of isolated diastolic hypertension didn't differ both studied groups (p>0.05). Conclusion. In 4/5 of type 2 diabetic patients arterial hypertension on the ground of ABPM system was detected. Systolic - diastolic hypertension was the predominant diagnosed arterial hypertension in type 2 diabetic patients. [ABSTRACT FROM AUTHOR]

Aim. The aim of this study was evaluation of value of „white coat effect" in hypertensive patients with and without type 2 diabetes. Material and method. The study group (group 1) comprised 53 hypertensive type 2 diabetic patients. Control group consisted of 51 hypertensive patients without diabetes (group 2). 24h -- ambulatory blood pressure monitoring (ABPM) in all patients was performed. „Office blood pressure" values were collected during clinic visit with the use of mercurial sphygmomanometer. „White coat effect" was diagnosed when „office blood pressure" values were higher than ABPM values. Results. No difference between studied groups in blood pressure values measured with the use of mercurial sphygmomanometer was observed (p>0.05). No difference between studied groups in blood pressure values measured in ABPM was observed (p>0.05). There were no differences in value of „white coat effect" for blood pressure between both groups (p>0.05). Conclusions. There were not differences in value of „white coat effect" in hypertensive patients with type 2 diabetes and without diabetes. [ABSTRACT FROM AUTHOR]

The most important problem in type 2 diabetes patients are cardiovascular complications. It influence on quality of life and longevity. Level of metabolic control, especially postprandial glicemia, cholesterol level and blood pressure control have the same role in the process of complications developmet. Frequency of glicemic control and kind of therapy may change the course of disease. Patients need permanent diet and treatment control. Therefore, they must be very motivated and educated. Diabetes care centers are the worst places for it. We must lead to increase of specilistic treatment. [ABSTRACT FROM AUTHOR]