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A low basal level of growth hormone (GH) was determined by radioimmunoassay in studying GH basal content, the circadian rhythm and the response to glucose load in patients with hyperprolactinemia. In subjects with hypophyseal adenoma, an anomalous GH response to glucose load and the disturbance of its circadian rhythm are seen. In patients not suffering from hypophyseal adenoma, the circadian curve of GH content is similar to the normal one on a lower level. A pronounced GH response to glucose load is absent in these patients.

A total of 76 patients aged 18-39 with hyperprolactinemia were studied for the blood levels of serotonin and histamine and for the urinary ones of epinephrine, norepinephrine, dopa and dopamine. Blood levels of serotonin and histamine were recorded increased whereas the urinary levels of catecholamines were decreased. No correlation was shown between the intensity in the production of lactogenic hormone and those abnormalities found in the levels of the above mentioned amino groups. The shifts observed were supposed to reflect those general tendencies which took place in the central regulatory mechanisms of the gonadal system in patients with excessive production of lactogenic hormone.