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Pain, tactile, vibration and temperature sensitivity, and also electroexcitability of individual nerves were determined. Neuropathy incidence was almost the same among males and females. There was found no association between neuropathy and excessive weight of the patients and the type of treatment. The frequency of affection increased with the advance of age and was maximum (40.4%) in patients aged from 55 to 64 years. The frequency of neuropathy proved to depend on the duration of diabetes. Sensitivity was chiefly distributed by distal and polyneuritic type. Affection of the lower limbs occurred in all the cases. Improvement after the treatment was noted in 69.3% of patients; however, in 13.5% of cases only it was objective in character. The irritative-pain syndrome was the one which yielded to the treatment best. Analysis of the results demonstrated the treatment to be more affective in younger persons with a lesser duration and severity of diabetes. The duration of partial remission constituted from 3 to 13 months. This pointed to the necessity of prophylactic therapeutic courses.

Results of examination of 257 patients suffering from diabetes mellitus demonstrated a reduction of sodium, potassium and magnesium content in their plasma. Erythrocytes also displayed a reduction of potassium and magnesium, and some increase of sodium content. Reduction of electrolyte level in the plasma and erythrocytes was more pronounced in winter; the erythrocyte sodium content was less in summer than in winter. The 24-hour sodium potassium and magnesium excretion is increased, during winter in particular. The efficacy of treatment of diabetic patients with panangin and potassium chloride for the purpose of elimination of magnesium and potassium deficiency was demonstrated. A conclusion was drawn on the expediency of using these drugs in the complex treatment of diabetic patients, particularly in winter.

Papers with evidence of the efficacy of therapy of patients suffering from diabetes insipidus with chlorpropamide, miscleron, carbamazepine, and maninil have appeared of late in the literature. This is the author's first experience in the use of indomethacin for the treatment of 14 patients with diabetes insipidus. Decreased diuresis, thirst and the improved general status were observed.