1. Preeclampsia among women with COVID-19 during pregnancy and its impact on maternal and perinatal outcomes: Results from a national multicenter study on COVID in Brazil, the REBRACO initiative
- Author
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José P. Guida, Jose G. Cecatti, Renato T. Souza, Rodolfo C. Pacagnella, Carolina C. Ribeiro-do-Valle, Adriana G. Luz, Giuliane J. Lajos, Fernanda G. Surita, Guilherme M. Nobrega, Thayna B. Griggio, Charles M. Charles, Maria J. Miele, Silvana B. Ferreira, Ricardo P. Tedesco, Karayna G. Fernandes, Sérgio H.A. Martins-Costa, José G.L. Ramos, Frederico J.A. Peret, Francisco E. Feitosa, Evelyn Traina, Edson V. Cunha-Filho, Janete Vettorazzi, Samira M. Haddad, Carla B. Andreucci, Mário D. Correa-Junior, Jussara Mayrink, Marcos A.B. Dias, Leandro G. Oliveira, Elias F. Melo-Junior, Marília G.Q. da Luz, and Maria Laura Costa
- Subjects
Cesarean Section ,Infant, Newborn ,Pregnancy Outcome ,Obstetrics and Gynecology ,COVID-19 ,Pregnancy Complications ,Pre-Eclampsia ,Pregnancy ,Hypertension ,Internal Medicine ,Humans ,Female ,Obesity ,Brazil - Abstract
To evaluate the prevalence of preeclampsia among cases of COVID-19 infection during pregnancy and the association between both conditions, in a multicenter cohort of Brazilian women with respiratory symptoms.Ancillary analysis of the Brazilian Network of COVID-19 in Obstetrics (REBRACO) study. We performed a nested case-control analysis selecting all women with COVID-19 and compared outcomes between women with and without PE.Maternal, gestational, and clinical characteristics and perinatal outcomes.Prevalence ratio (PR) and its 95%CI for each of the predictors and outcomes.A total of 203 women were included: 21 (10.3%) in PE group and 182 (89.7%) in non-PE group. Preeclampsia was not different among women with and without COVID-19 (10.3% vs 13.1%, p-value = 0.41), neither complication such as eclampsia and HELLP syndrome. Chronic hypertension (33.4%) (p 0.01) and obesity (60.0%) (p = 0.03) were the most frequent comorbidities in PE group, and they were significantly more frequent in this group. Women with PE had more cesarean section (RR 5.54 [1.33 - 23.14]) and their neonates were more frequently admitted to neonatal intensive care unit (PR 2.46[1.06 - 5.69]), most likely due to preterm-birth-related complications.The prevalence of PE among women with COVID-19 infection during pregnancy was around 10%; women with COVID-19 and a history of chronic hypertension or obesity are more likely to have preeclampsia. Cesarean section is increased among women with PE and COVID-19, with increased rates of neonatal admission to intensive care units, mostly due to prematurity.
- Published
- 2021