1. [Possible aggravation of a Henoch Schoenlein purpura by isotretinoin].
- Author
-
Derungs A, Eberhardt K, Heiniger U, Rudin C, and Brauchli Pernus YB
- Subjects
- Adolescent, Dermatologic Agents therapeutic use, Diagnosis, Differential, Drug Eruptions drug therapy, Humans, IgA Vasculitis diagnosis, IgA Vasculitis drug therapy, Isotretinoin therapeutic use, Leg Dermatoses diagnosis, Leg Dermatoses drug therapy, Male, Switzerland, Turkey ethnology, Acne Vulgaris drug therapy, Dermatologic Agents adverse effects, Drug Eruptions diagnosis, Emigrants and Immigrants, Glucocorticoids administration & dosage, IgA Vasculitis chemically induced, Isotretinoin adverse effects, Leg Dermatoses chemically induced
- Abstract
We report on a 16 year old patient with a hemorrhagic bullous form of a Henoch-Schönlein purpura. The cause for the event could not be determined, but the patient recovered without complications. Since he had begun a therapy with isotretinoin due to an acne inversa 3 weeks before, a possible association between the event and the treatment could not be excluded, and the case was reported to Swissmedic. In the comment, we discuss the pharmacology of isotretinoin, drug-induced vasculitis, and its pathomechanisms. As a general reminder, the criteria for the causality assessment of adverse drug reactions as well as the reporting system of adverse drug reactions in Switzerland are discussed.
- Published
- 2012
- Full Text
- View/download PDF