1. Evaluation of serum chemokine RANTES concentration as a biomarker in the diagnosis of early-onset severe infections in neonates
- Author
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Anna Szymańska, Dominika Wiśniewska-Ulfig, Behrendt Jakub, Anna Goleniowska-Król, Magdalena Wąsek-Buko, Urszula Godula-Stuglik, and Małgorzata Stojewska
- Subjects
Male ,0301 basic medicine ,Microbiology (medical) ,medicine.medical_specialty ,Chemokine ,Urinary system ,lcsh:Medicine ,Gestational Age ,Gastroenterology ,Sepsis ,RANTES ,Leukocyte Count ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Vein ,Chemokine CCL5 ,Early onset ,Asphyxia ,full-term neonate ,biology ,business.industry ,lcsh:R ,Infant, Newborn ,Gestational age ,030208 emergency & critical care medicine ,Pneumonia ,Fetal Blood ,medicine.disease ,030104 developmental biology ,Infectious Diseases ,medicine.anatomical_structure ,preterm neonate ,Immunology ,biology.protein ,Biomarker (medicine) ,organ infection ,Female ,medicine.symptom ,business ,Biomarkers ,Infant, Premature - Abstract
Objective: Only a few studies on improving the early diagnosis of severe neonatal infections have focused on the role of serum RANTES concentration (sRC). The aim of the study was to establish sRC in neonates with early-onset infections, according to their gestational age, sex, birth asphyxia, mode of delivery and value of some biochemical and hematological parameters.Material/Methods: The analysis comprised 129 neonates, including 89 infected (52 preterm, 37 full-term; 43 with sepsis, 39 with congenital pneumonia, 7 with severe urinary tract infection) and 40 healthy (control group, 25 full-term, 15 preterm). The sRC in peripheral vein blood was measured by the ELISA method using Quantikine Set (R & D systems, USA).Results: The sRC in infected neonates ranged from 10.83 to 122.55 μg/ml, in full-term neonates from 18.28 to 122.55 μg/ml, and in preterm from 10.83 to 118.24 μg/ml. The mean sRCs in full-term septic neonates (73.95±25.99 μg/ml) and with organ infections (58.43±29.24 μg/ml) were significantly higher than healthy ones (28.25±14.06 μg/ml). The mean sRCs in septic preterm neonates (59.17±28.29 μg/ml) and those with organ infections (50.86±28.16) were significantly higher than in healthy preterm neonates (25.61±8.29 μg/ml). Positive correlations between sRC and CRP value (r=0.3014, p=0.004) and between sRC and band cell count (r=0.2489, p=0.019) were found in all infected neonates. Conclusion. The significant increase of serum RANTES concentration in early-onset infections in neonates, regardless of their gestational age, sex and birth asphyxia, not only proves the presence of an active immunological process but also may be a useful biomarker for diagnosis of severe neonatal infections.
- Published
- 2016