1. Synthesis and antiproliferative activity of ionic platinum(II) triphenylphosphino complexes.
- Author
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Belli Dell’ Amico, Daniela, Labella, Luca, Marchetti, Fabio, Samaritani, Simona, Hernández-Fuentes, Gustavo Alejandro, García-Argáez, Aída Nelly, and Dalla Via, Lisa
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METAL complexes , *COMPLEX compounds synthesis , *PLATINUM compounds , *TRIPHENYLPHOSPHINE , *PHENANTHROLINE , *DEHALOGENATION - Abstract
Ionic platinum(II) complexes [PtCl(PPh 3 )(L∧L)][BF 4 ] {L∧L = 2,2′-bipyridyl ( 1 ) 1,10-phenanthroline ( 2 )} and [PtCl(PPh 3 )(L) 2 ][BF 4 ] {L = pyridine ( 3 ), dimethyl sulfoxide ( 4 )} were synthesized by dehalogenation of cis- [PtCl 2 (PPh 3 )(NCMe)], followed by reaction with the suitable ligand. Chelating nitrogen ligands L∧L afforded single products, which were structurally characterized. In the other cases mixtures of geometric (L = pyridine) and/or coordination (L = dimethyl sulfoxide) isomers were observed in solution. In these cases the structures of the less soluble isomers were obtained via single crystal X-ray diffraction. All the complexes were tested in vitro for their antiproliferative activity on three human tumor cell lines: MSTO-211H, HeLa and HepG2. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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