1. Facile Synthesis and Antioxidant Activity Screening of Some Novel 3-Substituted Indole Derivatives.
- Author
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Elgubbi, Amna S., Alzahrani, Abdullah Y. A., El-Helw, Eman A. E., and Shaban, Safaa S.
- Subjects
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CHEMICAL synthesis , *ACYL chlorides , *VITAMIN C , *INDOLE derivatives , *NUCLEOPHILES , *ANTIOXIDANTS - Abstract
The 2-cyano-3-(indol-3-yl)acryloyl chloride, a building block synthon prepared in good yield, was utilized for the synthesis of various indolylacrylamide and indole-based heterocycles. Thus, the aforementioned acid chloride was allowed to react with various oxygen, sulfur, and nitrogen nucleophiles, in addition to mono- and bidentate nucleophiles. The pyrazolidine derivatives were produced on interactions with phenylhydrazine and 2-cyanoethanohydrazide. The antioxidant activity of the synthesized compounds was assessed using the phosphomolybdenum technique and ascorbic acid as a standard. The findings displayed that indolyl-based azine, pyrazolidine, cyanoacetamide, and benzodiazepine derivatives were the most active antioxidants. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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