Search

Your search keyword '"Chalecka-Franaszek E"' showing total 3 results
Start Over Author "Chalecka-Franaszek E" Journal polish journal of pharmacology and pharmacy
3 results on '"Chalecka-Franaszek E"'

1. Different calcium requirements during incorporation of myo-inositol into membrane lipids for phosphatidylinositol hydrolysis stimulated by carbachol and noradrenaline.

Author

Nalepa I, Chalecka-Franaszek E, and Vetulani J

Subjects
Analysis of Variance, Animals, Brain drug effects, Brain metabolism, Hydrolysis drug effects, Male, Rats, Rats, Inbred Strains, Receptors, Adrenergic drug effects, Receptors, Adrenergic metabolism, Receptors, Muscarinic drug effects, Receptors, Muscarinic metabolism, Calcium physiology, Carbachol pharmacology, Inositol metabolism, Membrane Lipids metabolism, Norepinephrine pharmacology, Phosphatidylinositols metabolism
Abstract

Stimulation of phosphatidylinositol hydrolysis by noradrenaline requires the presence of calcium in the medium during the whole incubation and preincubation procedure, while carbachol-induced inositol phosphate formation is equally efficient in calcium-free and calcium-containing medium. This finding confirms the notion that phosphatidylinositols mobilized after stimulation of various receptors are present in different metabolic pools: the pool mobilized by alpha 1 adrenoceptors is apparently formed from myo-inositol incorporated into membrane phospholipids by a calcium-dependent process.

Published
1990

2. Differences in beta-adrenergic regulation of cyclic AMP formation in cerebral cortical slices of the rat and spiny mouse--Acomys cahirinus.

Author

Chalecka-Franaszek E, Nalepa I, and Vetulani J

Subjects
Adrenergic alpha-Agonists pharmacology, Adrenergic beta-Agonists pharmacology, Animals, Clonidine metabolism, Dihydroalprenolol, In Vitro Techniques, Male, Norepinephrine antagonists & inhibitors, Norepinephrine pharmacology, Prazosin pharmacology, Propranolol pharmacology, Rats, Rats, Inbred Strains, Second Messenger Systems physiology, Species Specificity, Synaptosomes drug effects, Synaptosomes metabolism, Cerebral Cortex metabolism, Cyclic AMP biosynthesis, Muridae metabolism, Receptors, Adrenergic, beta physiology
Abstract

In both the rat and Acomys cahirinus the adrenergic cyclic AMP generating system in the brain is dependent not only on beta-, but also on alpha-adrenoceptors. The relative role of alpha-adrenoceptors is much greater in the Acomys cahirinus. This feature makes the Acomys an interesting animal model for investigating the role of alpha-beta-adrenoceptor coupling in generation of cyclic AMP and the mechanism of action of antidepressant treatment.

Published
1990

3. Lack of effect of chronic imipramine administration on beta-adrenoceptor density on rat lymphocytes.

Author

Chalecka-Franaszek E and Vetulani J

Subjects
Animals, Cerebral Cortex drug effects, Dihydroalprenolol metabolism, Lymphocytes drug effects, Male, Rats, Rats, Inbred Strains, Cerebral Cortex metabolism, Imipramine pharmacology, Lymphocytes metabolism, Receptors, Adrenergic, beta drug effects
Abstract

Chronic administration of imipramine with drinking water to Wistar rats for two months did not affect the [3H]dihydroalprenolol binding to lymphocytic membranes, though the treatment depressed the radioligand binding to cerebral cortical membranes. The result suggests that the beta-adrenoceptor downregulation caused by the antidepressant in the central nervous system is not reflected in the lymphocytes.

Published
1986

Catalog

Books, media, physical & digital resources
See catalog results