Search

Your search keyword '"Waters, Andrew P"' showing total 13 results
Start Over Author "Waters, Andrew P" Journal plos pathogens
13 results on '"Waters, Andrew P"'

5. Three Members of the 6-cys Protein Family of Plasmodium Play a Role in Gamete Fertility

Author

van Dijk, Melissa R., primary, van Schaijk, Ben C. L., additional, Khan, Shahid M., additional, van Dooren, Maaike W., additional, Ramesar, Jai, additional, Kaczanowski, Szymon, additional, van Gemert, Geert-Jan, additional, Kroeze, Hans, additional, Stunnenberg, Hendrik G., additional, Eling, Wijnand M., additional, Sauerwein, Robert W., additional, Waters, Andrew P., additional, and Janse, Chris J., additional

Published
2010
Full Text
View/download PDF

8. Correction: The Glutathione Biosynthetic Pathway of Plasmodium Is Essential for Mosquito Transmission

Author

Vega-Rodríguez, Joel, primary, Franke-Fayard, Blandine, additional, Dinglasan, Rhoel R., additional, Janse, Chris J., additional, Pastrana-Mena, Rebecca, additional, Waters, Andrew P., additional, Coppens, Isabelle, additional, Rodríguez-Orengo, José F., additional, Srinivasan, Prakash, additional, Jacobs-Lorena, Marcelo, additional, and Serrano, Adelfa E., additional

Published
2009
Full Text
View/download PDF

10. Proteomic Profiling of Plasmodium Sporozoite Maturation Identifies New Proteins Essential for Parasite Development and Infectivity

Author

Lasonder, Edwin, primary, Janse, Chris J., additional, van Gemert, Geert-Jan, additional, Mair, Gunnar R., additional, Vermunt, Adriaan M. W., additional, Douradinha, Bruno G., additional, van Noort, Vera, additional, Huynen, Martijn A., additional, Luty, Adrian J. F., additional, Kroeze, Hans, additional, Khan, Shahid M., additional, Sauerwein, Robert W., additional, Waters, Andrew P., additional, Mann, Matthias, additional, and Stunnenberg, Hendrik G., additional

Published
2008
Full Text
View/download PDF

11. Correction: The Malaria Secretome: From Algorithms to Essential Function in Blood Stage Infection

Author

van Ooij, Christiaan, primary, Tamez, Pamela, additional, Bhattacharjee, Souvik, additional, Hiller, N. Luisa, additional, Harrison, Travis, additional, Liolios, Konstantinos, additional, Kooij, Taco, additional, Ramesar, Jai, additional, Balu, Bharath, additional, Adams, John, additional, Waters, Andrew P., additional, Janse, Chris J., additional, and Haldar, Kasturi, additional

Published
2008
Full Text
View/download PDF

13. The malaria secretome: from algorithms to essential function in blood stage infection.

Author

van Ooij C, Tamez P, Bhattacharjee S, Hiller NL, Harrison T, Liolios K, Kooij T, Ramesar J, Balu B, Adams J, Waters AP, Janse CJ, and Haldar K

Subjects
Animals, Conserved Sequence, Erythrocytes parasitology, Genomics methods, Humans, Malaria, Plasmodium falciparum chemistry, Protein Transport, Protozoan Proteins genetics, Rodentia, Algorithms, Plasmodium falciparum pathogenicity, Protein Sorting Signals, Protozoan Proteins metabolism
Abstract

The malaria agent Plasmodium falciparum is predicted to export a "secretome" of several hundred proteins to remodel the host erythrocyte. Prediction of protein export is based on the presence of an ER-type signal sequence and a downstream Host-Targeting (HT) motif (which is similar to, but distinct from, the closely related Plasmodium Export Element [PEXEL]). Previous attempts to determine the entire secretome, using either the HT-motif or the PEXEL, have yielded large sets of proteins, which have not been comprehensively tested. We present here an expanded secretome that is optimized for both P. falciparum signal sequences and the HT-motif. From the most conservative of these three secretome predictions, we identify 11 proteins that are preserved across human- and rodent-infecting Plasmodium species. The conservation of these proteins likely indicates that they perform important functions in the interaction with and remodeling of the host erythrocyte important for all Plasmodium parasites. Using the piggyBac transposition system, we validate their export and find a positive prediction rate of approximately 70%. Even for proteins identified by all secretomes, the positive prediction rate is not likely to exceed approximately 75%. Attempted deletions of the genes encoding the conserved exported proteins were not successful, but additional functional analyses revealed the first conserved secretome function. This gave new insight into mechanisms for the assembly of the parasite-induced tubovesicular network needed for import of nutrients into the infected erythrocyte. Thus, genomic screens combined with functional assays provide unexpected and fundamental insights into host remodeling by this major human pathogen.

Published
2008
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results