Search

Your search keyword '"Bozdech Zbynek"' showing total 9 results
Start Over Author "Bozdech Zbynek" Journal plos pathogens
9 results on '"Bozdech Zbynek"'

1. Short tandem repeat polymorphism in the promoter region of cyclophilin 19B drives its transcriptional upregulation and contributes to drug resistance in the malaria parasite Plasmodium falciparum

Author

Kucharski, Michal, primary, Wirjanata, Grennady, additional, Nayak, Sourav, additional, Boentoro, Josephine, additional, Dziekan, Jerzy Michal, additional, Assisi, Christina, additional, van der Pluijm, Rob W., additional, Miotto, Olivo, additional, Mok, Sachel, additional, Dondorp, Arjen M., additional, and Bozdech, Zbynek, additional

Published
2023
Full Text
View/download PDF

7. Plasmodium falciparum Heterochromatin Protein 1 Marks Genomic Loci Linked to Phenotypic Variation of Exported Virulence Factors

Author

Flueck, Christian, primary, Bartfai, Richard, additional, Volz, Jennifer, additional, Niederwieser, Igor, additional, Salcedo-Amaya, Adriana M., additional, Alako, Blaise T. F., additional, Ehlgen, Florian, additional, Ralph, Stuart A., additional, Cowman, Alan F., additional, Bozdech, Zbynek, additional, Stunnenberg, Hendrik G., additional, and Voss, Till S., additional

Published
2009
Full Text
View/download PDF

9. Antibodies Targeting the PfRH1 Binding Domain Inhibit Invasion of Plasmodium falciparum Merozoites.

Author

Xiaohong Gao, Kim Pin Yeo, Siqi Sharon Aw, Kuss, Claudia, Iyer, Jayasree K., Genesan, Saraswathy, Rajamanonmani, Ravikumar, Lescar, Julien, Bozdech, Zbynek, and Preiser, Peter R.

Subjects
MALARIA, PLASMODIUM falciparum, CARRIER proteins, ERYTHROCYTES, CYSTEINE proteinases, LIGANDS (Biochemistry), IMMUNOGLOBULINS
Abstract

Invasion by the malaria merozoite depends on recognition of specific erythrocyte surface receptors by parasite ligands. Plasmodium falciparum uses multiple ligands, including at least two gene families, reticulocyte binding protein homologues (RBLs) and erythrocyte binding proteins/ligands (EBLs). The combination of different RBLs and EBLs expressed in a merozoite defines the invasion pathway utilized and could also play a role in parasite virulence. The binding regions of EBLs lie in a conserved cysteine-rich domain while the binding domain of RBL is still not well characterized. Here, we identify the erythrocyte binding region of the P. falciparum reticulocyte binding protein homologue 1 (PfRH1) and show that antibodies raised against the functional binding region efficiently inhibit invasion. In addition, we directly demonstrate that changes in the expression of RBLs can constitute an immune evasion mechanism of the malaria merozoite. [ABSTRACT FROM AUTHOR]

Published
2008
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results