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Your search keyword '"van der Kraan, Peter M"' showing total 8 results
Start Over Author "van der Kraan, Peter M" Journal plos one
8 results on '"van der Kraan, Peter M"'

2. Correction: Supplementation of diet with non-digestible oligosaccharides alters the intestinal microbiota, but not arthritis development, in IL-1 receptor antagonist deficient mice

Author

Rogier, Rebecca, primary, Ederveen, Thomas H. A., additional, Wopereis, Harm, additional, Hartog, Anita, additional, Boekhorst, Jos, additional, van Hijum, Sacha A. F. T., additional, Knol, Jan, additional, Garssen, Johan, additional, Walgreen, Birgitte, additional, Helsen, Monique M., additional, van der Kraan, Peter M., additional, van Lent, Peter L. E. M., additional, van de Loo, Fons A. J., additional, Abdollahi-Roodsaz, Shahla, additional, and Koenders, Marije I., additional

Published
2019
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3. Supplementation of diet with non-digestible oligosaccharides alters the intestinal microbiota, but not arthritis development, in IL-1 receptor antagonist deficient mice

Author

Rogier, Rebecca, Ederveen, Thomas H A, Wopereis, Harm, Hartog, Anita, Boekhorst, Jos, van Hijum, Sacha A F T, Knol, Jan, Garssen, Johan, Walgreen, Birgitte, Helsen, Monique M, van der Kraan, Peter M, van Lent, Peter L E M, van de Loo, Fons A J, Abdollahi-Roodsaz, Shahla, Koenders, Marije I, Sub Theoretical Biology & Bioinformatics, Afd Pharmacology, Pharmacology, Sub Theoretical Biology & Bioinformatics, Afd Pharmacology, and Pharmacology

Subjects
Male, 0301 basic medicine, medicine.medical_treatment, Inflammatory arthritis, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Oligosaccharides, Arthritis, Gut flora, Biochemistry, Feces, Mice, 0302 clinical medicine, Microbiologie, Bone Density, T-Lymphocyte Subsets, Medicine and Health Sciences, Mice, Knockout, Mice, Inbred BALB C, Multidisciplinary, biology, Genomics, Animal Models, T helper cell, medicine.anatomical_structure, Experimental Organism Systems, Medical Microbiology, Connective Tissue, Experimental pathology, Medicine, Female, Anatomy, medicine.symptom, Inflammatory diseases Radboud Institute for Molecular Life Sciences [Radboudumc 5], Research Article, medicine.medical_specialty, Bone and Mineral Metabolism, Science, Immunology, Rheumatoid Arthritis, Mouse Models, Inflammation, Microbial Genomics, Research and Analysis Methods, Microbiology, Autoimmune Diseases, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, Model Organisms, Rheumatology, Internal medicine, Genetics, medicine, Life Science, Animals, MolEco, Host-Microbe Interactomics, Microbiome, Bone, Molecular Biology, Nutrition, VLAG, Prebiotic, Biology and Life Sciences, Receptors, Interleukin-1, Correction, biology.organism_classification, medicine.disease, Arthritis, Experimental, Diet, Gastrointestinal Microbiome, Gastrointestinal Tract, Interleukin 1 Receptor Antagonist Protein, Lactobacillus, Biological Tissue, Metabolism, Prebiotics, 030104 developmental biology, Endocrinology, Dietary Supplements, Animal Studies, Clinical Immunology, Clinical Medicine, Digestive System, 030215 immunology
Abstract

The intestinal microbiome is perturbed in patients with new-onset and chronic autoimmune inflammatory arthritis. Recent studies in mouse models suggest that development and progression of autoimmune arthritis is highly affected by the intestinal microbiome. This makes modulation of the intestinal microbiota an interesting novel approach to suppress inflammatory arthritis. Prebiotics, defined as non-digestible carbohydrates that selectively stimulate the growth and activity of beneficial microorganisms, provide a relatively non-invasive approach to modulate the intestinal microbiota. The aim of this study was to assess the therapeutic potential of dietary supplementation with a prebiotic mixture of 90% short-chain galacto-oligosaccharides and 10% long-chain fructo-oligosaccharides (scGOS/lcFOS) in experimental arthritis in mice. We here show that dietary supplementation with scGOS/ lcFOS has a pronounced effect on the composition of the fecal microbiota. Interestingly, the genera Enterococcus and Clostridium were markedly decreased by scGOS/lcFOS dietary supplementation. In contrast, the family Lachnospiraceae and the genus Lactobacillus, both associated with healthy microbiota, increased in mice receiving scGOS/lcFOS diet. However, the scGOS/lcFOS induced alterations of the intestinal microbiota did not induce significant effects on the intestinal and systemic T helper cell subsets and were not sufficient to reproducibly suppress arthritis in mice. As expected, we did observe a significant increase in the bone mineral density in mice upon dietary supplementation with scGOS/lcFOS for 8 weeks. Altogether, this study suggests that dietary scGOS/lcFOS supplementation is able to promote presumably healthy gut microbiota and improve bone mineral density, but not inflammation, in arthritis-prone mice.

Published
2019

5. Higher efficacy of anti-IL-6/IL-21 combination therapy compared to monotherapy in the induction phase of Th17-driven experimental arthritis

Author

Roeleveld, Debbie M., primary, Marijnissen, Renoud J., additional, Walgreen, Birgitte, additional, Helsen, Monique M., additional, van den Bersselaar, Liduine, additional, van de Loo, Fons A., additional, van Lent, Peter L., additional, van der Kraan, Peter M., additional, van den Berg, Wim B., additional, and Koenders, Marije I., additional

Published
2017
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7. Activin Receptor-Like Kinase Receptors ALK5 and ALK1 Are Both Required for TGFβ-Induced Chondrogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells

Author

de Kroon, Laurie M. G., primary, Narcisi, Roberto, additional, Blaney Davidson, Esmeralda N., additional, Cleary, Mairéad A., additional, van Beuningen, Henk M., additional, Koevoet, Wendy J. L. M., additional, van Osch, Gerjo J. V. M., additional, and van der Kraan, Peter M., additional

Published
2015
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8. Commercial Cow Milk Contains Physically Stable Extracellular Vesicles Expressing Immunoregulatory TGF-β

Author

Pieters, Bartijn C. H., primary, Arntz, Onno J., additional, Bennink, Miranda B., additional, Broeren, Mathijs G. A., additional, van Caam, Arjan P. M., additional, Koenders, Marije I., additional, van Lent, Peter L. E. M., additional, van den Berg, Wim B., additional, de Vries, Marieke, additional, van der Kraan, Peter M., additional, and van de Loo, Fons A. J., additional

Published
2015
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