1. Micronutrient fortification to improve growth and health of maternally HIV-unexposed and exposed Zambian infants: a randomised controlled trial
- Author
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Filteau, Suzanne, Kasonka, Lackson, Gibson, Rosalind, Gompels, Ursula A., Jaffar, Shabbar, Kafwembe, Emmanuel, Monze, Mwaka, Sinkala, Moses, Tomkins, Andrew, Zulu, Rodah, Chisenga, Molly, Siame, Joshua, Mabuda, Hildah Banda, Baisley, Kathy, Dale, Helen, Rehman, Andrea, Bates, Matthew, Mullen, Anne, Bwalya, Hellen Kangwa, Chileshe, Margaret, Kowa, Priscilla Kangwa, Kumwenda, Mabvuto, Likando, Munalula, Mambwe, Sydney, Muzyamba, Mutinta, Mwale, Anne, Nyaywa, Lungowe, Kapambwe, Mirriam, Bima, Humphrey, Gosset, Laura, Hackett, Louise, Jackson, Abigail, Njunju, Eric, Mwanza, Sydney, Shampwaya, Natalia, Kabanga, Concillia, Chobo, John, Kapumba, Winford, Musonda, Charity, and Soko, Philip
- Subjects
Pediatrics ,medicine.medical_specialty ,A300 Clinical Medicine ,Anemia ,Breastfeeding ,Pediatrics and Child Health ,Zambia ,lcsh:Medicine ,HIV Infections ,Growth ,Breast milk ,Double-Blind Method ,Pregnancy ,Medicine ,Humans ,Micronutrients ,Pregnancy Complications, Infectious ,lcsh:Science ,Multidisciplinary ,business.industry ,lcsh:R ,Infant Welfare ,Infant ,Odds ratio ,Public Health and Epidemiology/Global Health ,Infectious Diseases/HIV Infection and AIDS ,medicine.disease ,Micronutrient ,Nutrition/Malnutrition ,Breast Feeding ,Maternal Exposure ,Population study ,Female ,lcsh:Q ,business ,Breast feeding ,Research Article - Abstract
BACKGROUND: The period of complementary feeding, starting around 6 months of age, is a time of high risk for growth faltering and morbidity. Low micronutrient density of locally available foods is a common problem in low income countries. Children of HIV-infected women are especially vulnerable. Although antiretroviral prophylaxis can reduce breast milk HIV transmission in early infancy, there are no clear feeding guidelines for after 6 months. There is a need for acceptable, feasible, affordable, sustainable and safe (AFASS by WHO terminology) foods for both HIV-exposed and unexposed children after 6 months of age. METHODS AND FINDINGS: We conducted in Lusaka, Zambia, a randomised double-blind trial of two locally made infant foods: porridges made of flour composed of maize, beans, bambaranuts and groundnuts. One flour contained a basal and the other a rich level of micronutrient fortification. Infants (n = 743) aged 6 months were randomised to receive either regime for 12 months. The primary outcome was stunting (length-for-age Z
- Published
- 2010