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10 results on '"Zhou, Zuomin"'

3. The Role of RING Box Protein 1 in Mouse Oocyte Meiotic Maturation

Author

Zhou, Lin, primary, Yang, Ye, additional, Zhang, Juanjuan, additional, Guo, Xuejiang, additional, Bi, Ye, additional, Li, Xin, additional, Zhang, Ping, additional, Zhang, Junqiang, additional, Lin, Min, additional, Zhou, Zuomin, additional, Shen, Rong, additional, Guo, Xirong, additional, Huo, Ran, additional, Ling, Xiufeng, additional, and Sha, Jiahao, additional

Published
2013
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7. Bisphenol A Alters n-6 Fatty Acid Composition and Decreases Antioxidant Enzyme Levels in Rat Testes: A LC-QTOF-Based Metabolomics Study

Author

Chen, Minjian, primary, Xu, Bin, additional, Ji, Wenliang, additional, Qiao, Shanlei, additional, Hu, Nan, additional, Hu, Yanhui, additional, Wu, Wei, additional, Qiu, Lianglin, additional, Zhang, Ruyang, additional, Wang, Yubang, additional, Wang, Shoulin, additional, Zhou, Zuomin, additional, Xia, Yankai, additional, and Wang, Xinru, additional

Published
2012
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10. Tripeptidyl Peptidase II Regulates Sperm Function by Modulating Intracellular Ca2+ Stores via the Ryanodine Receptor.

Author

Zhou, Yuchuan, Ru, Yanfei, Wang, Chunmei, Wang, Shoulin, Zhou, Zuomin, and Zhang, Yonglian

Subjects
PEPTIDASE regulation, SPERMATOZOA, INTRACELLULAR calcium, CALCIUM ions, RYANODINE receptors, IN vitro studies, PROTEIN-tyrosine kinases
Abstract

Recent studies have identified Ca2+ stores in sperm cells; however, it is not clear whether these Ca2+ stores are functional and how they are mobilized. Here, in vitro and in vivo, we determined that tripeptidyl peptidase II antagonists strongly activated the cAMP/PKA signaling pathway that drives sperm capacitation-associated protein tyrosine phosphorylation. We demonstrated that in the absence of Ca2+, TPIII antagonists elevated the intracellular Ca2+ levels in sperm, resulting in a marked improvement in sperm movement, capacitation, acrosome reaction, and the in vitro fertilizing ability. This antagonist-induced release of intracellular Ca2+ could be blocked by the inhibitors of ryanodine receptors (RyRs) which are the main intracellular Ca2+ channels responsible for releasing stored Ca2+. Consistent with these results, indirect immunofluorescence assay using anti-RyR antibodies further validated the presence of RyR3 in the acrosomal region of mature sperm. Thus, TPPII can regulate sperm maturation by modulating intracellular Ca2+ stores via the type 3 RyR. [ABSTRACT FROM AUTHOR]

Published
2013
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