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2. Evaluation of a thermostable Newcastle disease virus strain TS09-C as an in-ovo vaccine for chickens

Author

Wen Guoyuan, Hongling Wang, Lintao Li, Qingping Luo, Zhang Tengfei, Qingzhong Yu, Wanpo Zhang, Huabin Shao, and Zhang Rongrong

Subjects
0301 basic medicine, RNA viruses, Physiology, Respiratory System, lcsh:Medicine, Antibodies, Viral, Pathology and Laboratory Medicine, Biochemistry, Poultry, Immune Physiology, Medicine and Health Sciences, Public and Occupational Health, Gamefowl, lcsh:Science, Vaccines, Multidisciplinary, Immune System Proteins, Immunogenicity, Viral Vaccine, Agriculture, Vaccination and Immunization, Vaccination, Trachea, Medical Microbiology, Viral Pathogens, Vertebrates, Viruses, embryonic structures, Pathogens, Anatomy, Research Article, Livestock, animal structures, Newcastle Disease, 030106 microbiology, Immunology, Newcastle disease virus, Biology, In ovo, Vaccines, Attenuated, Newcastle disease, Microbiology, Virus, Birds, 03 medical and health sciences, Immune system, Animals, Antigens, Microbial Pathogens, Poultry Diseases, lcsh:R, Organisms, Biology and Life Sciences, Proteins, Viral Vaccines, biology.organism_classification, Virology, Gastrointestinal Tract, 030104 developmental biology, Immunization, Fowl, Amniotes, Paramyxoviruses, lcsh:Q, Preventive Medicine, Chickens, Digestive System
Abstract

In-ovo vaccination is an attractive immunization approach for poultry industry. However, most of the Newcastle disease virus (NDV) vaccine strains used after hatch are unsafe, as in-ovo vaccines, due to their high pathogenicity for chicken embryos. In this study, we evaluated the safety and immunogenicity of a thermostable NDV strain TS09-C, derived from V4 strain, as in-ovo vaccine. Chickens in-ovo vaccinated with the parental V4 strain displayed greatly reduced hatchability and severe histopathological lesions in both trachea and intestine tissues, while the hatchability was not affected by in-ovo vaccination withTS09-C strain. The safe dose that infected all chicken embryos without obviously histopathological lesions was 103.0 EID50 per bird. In-ovo vaccination of chickens with TS09-C virus conferred complete protection against virulent NDV challenge. Results suggest that the thermostable NDV strain TS09-C is a safe and immunogenic in-ovo vaccine candidate that can be delivered quickly and uniformly, and induce earlier immune response.

Published
2017

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