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1. A tissue microRNA signature that predicts the prognosis of breast cancer in young women.

Author

Ai Hironaka-Mitsuhashi, Juntaro Matsuzaki, Ryou-U Takahashi, Masayuki Yoshida, Yutaka Nezu, Yusuke Yamamoto, Sho Shiino, Takayuki Kinoshita, Toshikazu Ushijima, Nobuyoshi Hiraoka, Chikako Shimizu, Kenji Tamura, and Takahiro Ochiya

Subjects
Medicine, Science
Abstract

Since breast cancers in young women are generally aggressive, young patients tend to be intensively treated with anti-cancer drugs. To optimize the strategy for treatment, particularly in young women, prognostic biomarkers are urgently required. The objective of this study was to identify a tissue microRNA (miRNA) signature that predicts prognosis in young breast cancer patients. Total RNA from 45 breast cancer patients aged 0.7. Five of the miRNAs were validated by qRT-PCR, and the expression levels of three of those five (miR-183-5p, miR-194-5p, and miR-1285-5p), both alone and in combination, were associated with OS. In conclusion, we identified three candidate miRNAs that could be used separately or in combination as prognostic biomarkers in young breast cancer patients. This miRNA signature may enable selection of better treatment choices for young women with this disease.

Published
2017
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2. A tissue microRNA signature that predicts the prognosis of breast cancer in young women

Author

Yusuke Yamamoto, Takahiro Ochiya, Takayuki Kinoshita, Nobuyoshi Hiraoka, Chikako Shimizu, Juntaro Matsuzaki, Ryou U. Takahashi, Kenji Tamura, Masayuki Yoshida, Sho Shiino, Ai Hironaka-Mitsuhashi, Yutaka Nezu, and Toshikazu Ushijima

Subjects
0301 basic medicine, Oncology, Microarrays, Total rna, Cancer Treatment, lcsh:Medicine, Disease, Biochemistry, 0302 clinical medicine, Breast Tumors, Medicine and Health Sciences, Medicine, lcsh:Science, Multidisciplinary, Treatment choices, Prognosis, Cancer treatment, Nucleic acids, Bioassays and Physiological Analysis, 030220 oncology & carcinogenesis, Female, Research Article, Mirna signature, Adult, medicine.medical_specialty, Surgical and Invasive Medical Procedures, Breast Neoplasms, Candidate mirnas, Research and Analysis Methods, 03 medical and health sciences, Breast cancer, Diagnostic Medicine, Internal medicine, microRNA, Breast Cancer, Genetics, Cancer Detection and Diagnosis, Humans, Non-coding RNA, Biology and life sciences, business.industry, lcsh:R, Cancers and Neoplasms, medicine.disease, Gene regulation, MicroRNAs, 030104 developmental biology, Cancer research, RNA, lcsh:Q, Gene expression, business, Biomarkers
Abstract

Since breast cancers in young women are generally aggressive, young patients tend to be intensively treated with anti-cancer drugs. To optimize the strategy for treatment, particularly in young women, prognostic biomarkers are urgently required. The objective of this study was to identify a tissue microRNA (miRNA) signature that predicts prognosis in young breast cancer patients. Total RNA from 45 breast cancer patients aged 0.7. Five of the miRNAs were validated by qRT-PCR, and the expression levels of three of those five (miR-183-5p, miR-194-5p, and miR-1285-5p), both alone and in combination, were associated with OS. In conclusion, we identified three candidate miRNAs that could be used separately or in combination as prognostic biomarkers in young breast cancer patients. This miRNA signature may enable selection of better treatment choices for young women with this disease.

Published
2017

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