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13 results on '"Yu, Lianbo"'

1. Expression of microRNAs and their target genes in melanomas originating from gynecologic sites

Author

DiVincenzo, Mallory J., primary, Angell, Colin D., additional, Suarez-Kelly, Lorena P., additional, Ren, Casey, additional, Barricklow, Zoe, additional, Moufawad, Maribelle, additional, Fadda, Paolo, additional, Yu, Lianbo, additional, Backes, Floor J., additional, Ring, Kari, additional, Mills, Anne, additional, Slingluff, Craig, additional, Chung, Catherine, additional, Gru, Alejandro A., additional, and Carson, William E., additional

Published
2023
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5. Impact of Pre-Analytical Variables on Cancer Targeted Gene Sequencing Efficiency

Author

Araujo, Luiz H., primary, Timmers, Cynthia, additional, Shilo, Konstantin, additional, Zhao, Weiqiang, additional, Zhang, Jianying, additional, Yu, Lianbo, additional, Natarajan, Thanemozhi G., additional, Miller, Clinton J., additional, Yilmaz, Ayse Selen, additional, Liu, Tom, additional, Amann, Joseph, additional, Lapa e Silva, José Roberto, additional, Ferreira, Carlos Gil, additional, and Carbone, David P., additional

Published
2015
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8. Ets2 in Tumor Fibroblasts Promotes Angiogenesis in Breast Cancer

Author

Wallace, Julie A., primary, Li, Fu, additional, Balakrishnan, Subhasree, additional, Cantemir-Stone, Carmen Z., additional, Pecot, Thierry, additional, Martin, Chelsea, additional, Kladney, Raleigh D., additional, Sharma, Sudarshana M., additional, Trimboli, Anthony J., additional, Fernandez, Soledad A., additional, Yu, Lianbo, additional, Rosol, Thomas J., additional, Stromberg, Paul C., additional, Lesurf, Robert, additional, Hallett, Michael, additional, Park, Morag, additional, Leone, Gustavo, additional, and Ostrowski, Michael C., additional

Published
2013
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9. Reduced Susceptibility of DNA Methyltransferase 1 Hypomorphic (Dnmt1N/+) Mice to Hepatic Steatosis upon Feeding Liquid Alcohol Diet

Author

Kutay, Huban, primary, Klepper, Corie, additional, Wang, Bo, additional, Hsu, Shu-hao, additional, Datta, Jharna, additional, Yu, Lianbo, additional, Zhang, Xiaoli, additional, Majumder, Sarmila, additional, Motiwala, Tasneem, additional, Khan, Nuzhat, additional, Belury, Martha, additional, McClain, Craig, additional, Jacob, Samson, additional, and Ghoshal, Kalpana, additional

Published
2012
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11. Correction: Detection of microRNA Expression in Human Peripheral Blood Microvesicles

Author

Hunter, Melissa Piper, primary, Ismail, Noura, additional, Zhang, Xiaoli, additional, Aguda, Baltazar D., additional, Lee, Eun Joo, additional, Yu, Lianbo, additional, Xiao, Tao, additional, Schafer, Jeffrey, additional, Lee, Mei-Ling Ting, additional, Schmittgen, Thomas D., additional, Nana-Sinkam, S. Patrick, additional, Jarjoura, David, additional, and Marsh, Clay B., additional

Published
2010
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12. Detection of microRNA Expression in Human Peripheral Blood Microvesicles

Author

Hunter, Melissa Piper, primary, Ismail, Noura, additional, Zhang, Xiaoli, additional, Aguda, Baltazar D., additional, Lee, Eun Joo, additional, Yu, Lianbo, additional, Xiao, Tao, additional, Schafer, Jeffrey, additional, Lee, Mei-Ling Ting, additional, Schmittgen, Thomas D., additional, Nana-Sinkam, S. Patrick, additional, Jarjoura, David, additional, and Marsh, Clay B., additional

Published
2008
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13. Reduced Susceptibility of DNA Methyltransferase 1 Hypomorphic (Dnmt1N/+) Mice to Hepatic Steatosis upon Feeding Liquid Alcohol Diet.

Author

Kutay, Huban, Klepper, Corie, Wang, Bo, Hsu, Shu-hao, Datta, Jharna, Yu, Lianbo, Zhang, Xiaoli, Majumder, Sarmila, Motiwala, Tasneem, Khan, Nuzhat, Belury, Martha, McClain, Craig, Jacob, Samson, Ghoshal, Kalpana, and Pal, Soumitro

Subjects
METHYLATION, DNA, METHYLTRANSFERASES, CANCER, ALCOHOLIC liver diseases, LABORATORY mice, ETHANOL
Abstract

Background: Methylation at C-5 (5-mdC) of CpG base pairs, the most abundant epigenetic modification of DNA, is catalyzed by 3 essential DNA methyltransferases (Dnmt1, Dnmt3a and Dnmt3b). Aberrations in DNA methylation and Dnmts are linked to different diseases including cancer. However, their role in alcoholic liver disease (ALD) has not been elucidated. Methodology/Principal Findings: Dnmtl wild type (Dnmt1+/+) and hypomorphic (Dnmt1N/+) male mice that express reduced level of Dnmt1 were fed Lieber-DeCarli liquid diet containing ethanol for 6 weeks. Control mice were pair-fed calorie-matched alcohol-free liquid diet, and Dnmtase activity, 5-mdC content, gene expression profile and liver histopathology were evaluated. Ethanol feeding caused pronounced decrease in hepatic Dnmtase activity in Dnmt1+/+ mice due to decrease in Dnmt1 and Dnmt3b protein levels and upregulation of miR-148 and miR-152 that target both Dnmt1 and Dnmt3b. Microarray and qPCR analysis showed that the genes involved in lipid, xenobiotic and glutathione metabolism, mitochondrial function and cell proliferation were dysregulated in the wild type mice fed alcohol. Surprisingly, Dnmt1N/+ mice were less susceptible to alcoholic steatosis compared to Dnmt1+/+ mice. Expression of several key genes involved in alcohol (Aldh3b1), lipid (Ppara, Lepr, Vldlr, Agpat9) and xenobiotic (Cyp39a1) metabolism, and oxidative stress (Mr-1, Fmo3) were significantly (P<0.05) altered in Dnmt1N/+ mice relative to the wild type mice fed alcohol diet. However, CpG islands encompassing the promoter regions of Agpat9, Lepr, Mr1 and Ppara were methylation-free in both genotypes irrespective of the diet, suggesting that promoter methylation does not regulate their expression. Similarly, 5-mdC content of the liver genome, as measured by LC-MS/MS analysis, was not affected by alcohol diet in the wild type or hypomorphic mice. Conclusions/Significance: Although feeding alcohol diet reduced Dnmtase activity, the loss of one copy of Dnmt1 protected mice from alcoholic hepatosteatosis by dysregulating genes involved in lipid metabolism and oxidative stress. [ABSTRACT FROM AUTHOR]

Published
2012
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