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3. The fine-scale genetic structure and evolution of the Japanese population.

Author

Takeuchi, Fumihiko, Katsuya, Tomohiro, Kimura, Ryosuke, Nabika, Toru, Isomura, Minoru, Ohkubo, Takayoshi, Tabara, Yasuharu, Yamamoto, Ken, Yokota, Mitsuhiro, Liu, Xuanyao, Saw, Woei-Yuh, Mamatyusupu, Dolikun, Yang, Wenjun, Xu, Shuhua, null, null, Teo, Yik-Ying, and Kato, Norihiro

Subjects
POPULATION genetics, JAPANESE people, HUMAN evolution, PRINCIPAL components analysis, SINGLE nucleotide polymorphisms, HAPLOTYPES
Abstract

The contemporary Japanese populations largely consist of three genetically distinct groups—Hondo, Ryukyu and Ainu. By principal-component analysis, while the three groups can be clearly separated, the Hondo people, comprising 99% of the Japanese, form one almost indistinguishable cluster. To understand fine-scale genetic structure, we applied powerful haplotype-based statistical methods to genome-wide single nucleotide polymorphism data from 1600 Japanese individuals, sampled from eight distinct regions in Japan. We then combined the Japanese data with 26 other Asian populations data to analyze the shared ancestry and genetic differentiation. We found that the Japanese could be separated into nine genetic clusters in our dataset, showing a marked concordance with geography; and that major components of ancestry profile of Japanese were from the Korean and Han Chinese clusters. We also detected and dated admixture in the Japanese. While genetic differentiation between Ryukyu and Hondo was suggested to be caused in part by positive selection, genetic differentiation among the Hondo clusters appeared to result principally from genetic drift. Notably, in Asians, we found the possibility that positive selection accentuated genetic differentiation among distant populations but attenuated genetic differentiation among close populations. These findings are significant for studies of human evolution and medical genetics. [ABSTRACT FROM AUTHOR]

Published
2017
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8. Tumor-Initiating Cells Are Enriched in CD44hi Population in Murine Salivary Gland Tumor

Author

Shen, Shukun, primary, Yang, Wenjun, additional, Wang, Zhugang, additional, Lei, Xia, additional, Xu, Liqun, additional, Wang, Yang, additional, Wang, Lizhen, additional, Huang, Lei, additional, Yu, Zhiwei, additional, Zhang, Xinhong, additional, Li, Jiang, additional, Chen, Yan, additional, Zhao, Xiaoping, additional, Yin, Xuelai, additional, and Zhang, Chenping, additional

Published
2011
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