1. Associations between body size, nutrition and socioeconomic position in early life and the epigenome: A systematic review
- Author
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Maddock, Jane, Wulaningsih, Wahyu, Fernandez, Juan Castillo, Ploubidis, George B., Goodman, Alissa, Bell, Jordana, Kuh, Diana, and Hardy, Rebecca
- Subjects
Epigenomics ,Cell biology ,Physiology ,Maternal Health ,Science ,Nutritional Status ,Biochemistry ,Methylation ,Pregnancy ,Genetics ,Medicine and Health Sciences ,Birth Weight ,Body Size ,Humans ,Child ,Nutrition ,DNA methylation ,Biology and life sciences ,Body Weight ,Chemical Reactions ,Infant, Newborn ,Obstetrics and Gynecology ,Infant ,DNA ,Chromatin ,Body Fluids ,Nucleic acids ,Chemistry ,Blood ,Physiological Parameters ,Social Class ,Research Design ,Child, Preschool ,Physical Sciences ,Women's Health ,Medicine ,Epigenetics ,Gene expression ,Independent Living ,Anatomy ,DNA modification ,Chromatin modification ,Research Article ,Chromosome biology - Abstract
BackgroundBody size, nutrition and socioeconomic position (SEP) in early life have been associated with a wide range of long-term health effects. Epigenetics is one possible mechanism through which these early life exposures can impact later life health. We conducted a systematic review examining the observational evidence for the impact of body size, nutrition and SEP in early life on the epigenome in humans.MethodsThis systematic review is registered with the PROSPERO database (registration number: CRD42016050193). Three datasets were simultaneously searched using Ovid and the resulting studies were evaluated by at least two independent reviewers. Studies measuring epigenetic markers either at the same time as, or after, the early life exposure and have a measure of body size, nutrition or SEP in early life (up to 12 years), written in English and from a community-dwelling participants were included.ResultsWe identified 90 eligible studies. Seventeen of these papers examined more than one early life exposure of interest. Fifty six papers examined body size, 37 nutrition and 17 SEP. All of the included papers examined DNA methylation (DNAm) as the epigenetic marker. Overall there was no strong evidence for a consistent association between these early life variables in DNAm which may be due to the heterogeneous study designs, data collection methods and statistical analyses.ConclusionsDespite these inconclusive results, the hypothesis that the early life environment can impact DNAm, potentially persisting into adult life, was supported by some studies and warrants further investigation. We provide recommendations for future studies.
- Published
- 2018