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Your search keyword '"Won Sang Jung"' showing total 2 results
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2 results on '"Won Sang Jung"'

1. Apathy and White Matter Integrity in Alzheimer’s Disease: A Whole Brain Analysis with Tract-Based Spatial Statistics

Author

Won-Sang Jung, Hyun-Kook Lim, Chang-Uk Lee, Changtae Hahn, Wang Yeon Won, and Kook Jin Ahn

Subjects
Male, Genu of the corpus callosum, Anatomy and Physiology, lcsh:Medicine, Audiology, Corpus callosum, Nerve Fibers, Myelinated, Diagnostic Radiology, Corpus Callosum, Cingulum (brain), Apathy, lcsh:Science, Psychiatry, Aged, 80 and over, Brain Mapping, Multidisciplinary, Brain, Magnetic Resonance Imaging, medicine.anatomical_structure, Mental Health, Diffusion Tensor Imaging, Neurology, Medicine, Female, medicine.symptom, Alzheimer's disease, Radiology, Research Article, medicine.medical_specialty, Splenium, Neuropsychiatric Disorders, Biology, Neurological System, White matter, Alzheimer Disease, Fractional anisotropy, medicine, Humans, Aged, Models, Statistical, lcsh:R, Reproducibility of Results, medicine.disease, Neuroanatomy, Anisotropy, lcsh:Q, Dementia, Neuroscience
Abstract

The aim of this study was to investigate the microstructural alterations of white matter (WM) in Alzheimer's disease (AD) patients with apathy and to observe the relationships with the severity of apathy. Sixty drug-naïve subjects took part in this study (30 apathetic and 30 nonapathetic subjects with AD). The loss of integrity in WM was compared in AD patients with and without apathy through measurement of fractional anisotropy (FA) using by tract-based spatial statistics (TBSS). In addition, we explored the correlation pattern between FA values and the severity of apathy in AD patients with apathy. The apathy group had significantly reduced FA values (p(corrected)

Published
2013

2. Apathy and White Matter Integrity in Alzheimer's Disease: A Whole Brain Analysis with Tract-Based Spatial Statistics.

Author

Changtae Hahn, Hyun-Kook Lim, Wang Yeon Won, Kook Jin Ahn, Won-Sang Jung, and Chang Uk Lee

Subjects
ALZHEIMER'S patients, APATHY, CORPUS callosum, BRAIN, CINGULA, FASCICULINS
Abstract

The aim of this study was to investigate the microstructural alterations of white matter (WM) in Alzheimer's disease (AD) patients with apathy and to observe the relationships with the severity of apathy. Sixty drug-naive subjects took part in this study (30 apathetic and 30 nonapathetic subjects with AD). The loss of integrity in WM was compared in AD patients with and without apathy through measurement of fractional anisotropy (FA) using by tract-based spatial statistics (TBSS). In addition, we explored the correlation pattern between FA values and the severity of apathy in AD patients with apathy. The apathy group had significantly reduced FA values (pcorrected<0.05) in the genu of the corpus callosum compared to the nonapathy group. The severity of apathy was negatively correlated with FA values of the left anterior and posterior cingulum, right superior longitudinal fasciculus, splenium, body and genu of the corpus callosum and bilateral uncinate fasciculusin the apathy group (pcorrected<0.05). This study was the first to explore FA values in whole brain WM in AD patients with apathy. The findings of these microstructural alterations of WM may be the key to the understanding of underlying neurobiological mechanism and clinical significances of apathy in AD. [ABSTRACT FROM AUTHOR]

Published
2013
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