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7 results on '"Wiertz, Emmanuel"'

2. Proteasomal Degradation of Proinsulin Requires Derlin-2, HRD1 and p97

Author

Hoelen, Hanneke, primary, Zaldumbide, Arnaud, additional, van Leeuwen, Wouter F., additional, Torfs, Ellen C. W., additional, Engelse, Marten A., additional, Hassan, Chopie, additional, Lebbink, Robert Jan, additional, de Koning, Eelco J., additional, Resssing, Maaike E., additional, de Ru, Arnoud H., additional, van Veelen, Peter A., additional, Hoeben, Rob C., additional, Roep, Bart O., additional, and Wiertz, Emmanuel J. H. J., additional

Published
2015
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4. Genetic Variability among Complete Human Respiratory Syncytial Virus Subgroup A Genomes: Bridging Molecular Evolutionary Dynamics and Epidemiology

Author

Tan, Lydia, primary, Lemey, Philippe, additional, Houspie, Lieselot, additional, C. Viveen, Marco, additional, Jansen, Nicolaas J. G., additional, van Loon, Anton M., additional, Wiertz, Emmanuel, additional, van Bleek, Grada M., additional, Martin, Darren P., additional, and Coenjaerts, Frank E., additional

Published
2012
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6. Exploitation of Herpesvirus Immune Evasion Strategies to Modify the Immunogenicity of Human Mesenchymal Stem Cell Transplants

Author

de la Garza-Rodea, Anabel S., primary, Verweij, Marieke C., additional, Boersma, Hester, additional, van der Velde-van Dijke, Ietje, additional, de Vries, Antoine A. F., additional, Hoeben, Rob C., additional, van Bekkum, Dirk W., additional, Wiertz, Emmanuel J. H. J., additional, and Knaän-Shanzer, Shoshan, additional

Published
2011
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7. TAP Mediates Import of Mycobacterium tuberculosis-Derived Peptides into Phagosomes and Facilitates Loading onto HLA-I.

Author

Harriff, Melanie J., Burgdorf, Sven, Kurts, Christian, Wiertz, Emmanuel J. H. J., Lewinsohn, Deborah A., and Lewinsohn, David M.

Subjects
MYCOBACTERIUM tuberculosis, PEPTIDES, PHAGOSOMES, HLA histocompatibility antigens, MHC antibodies, CYTOSOL, T cells, CD8 antigen
Abstract

Processing and presentation of antigen on MHC-I class I molecules serves to present peptides derived from cytosolic proteins to CD8+ T cells. Infection with bacteria that remain in phagosomal compartments, such as Mycobacterium tuberculosis (Mtb), provides a challenge to this immune recognition as bacterial proteins are segregated from the cytosol. Previously we identified the Mtb phagosome itself as an organelle capable of loading MHC Class I molecules with Mtb antigens. Here, we find that the TAP transporter, responsible for importing peptides into the ER for loading in Class I molecules, is both present and functional in Mtb phagosomes. Furthermore, we describe a novel peptide reagent, representing the N-terminal domain of the bovine herpes virus UL49.5 protein, which is capable of specifically inhibiting the lumenal face of TAP. Together, these results provide insight into the mechanism by which peptides from intra-phagosomal pathogens are loaded onto Class I molecules. [ABSTRACT FROM AUTHOR]

Published
2013
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