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1. Analysis of influencing factors of no/low response to preoperative concurrent chemoradiotherapy in locally advanced rectal cancer.

Author

Fengpeng Wu, Guiying Wang, Jun Wang, Chaoxi Zhou, Congrong Yang, Wenbo Niu, Jianfeng Zhang, Guanglin Wang, and Yafan Yang

Subjects
Medicine, Science
Abstract

The aim of this study is to investigate the influencing factors associated with no/low response to preoperative concurrent chemoradiotherapy (CCRT) for locally advanced rectal cancer (LARC) patients. A total of 79 patients were included in this prospective study. Fifteen factors that might affect the resistance to CCRT were included in this logistic regression analysis, these factors include the general clinical data of patients, the expression status of tumor stem cell marker CD44v6 and the volumetric imaging parameters of primary tumor lesions. We found that the no/low response status to preoperative CCRT was positively correlated with the real tumor volume (RTV), the total surface area of tumor (TSA), and CD44v6 expression, whereas negatively correlated with the tumor compactness (TC). According to the results of logistic regression analysis, two formulas that could predict whether or not no/low response to preoperative CCRT were established. The Area Under Curve (AUC) of the two formulas and those significant measurement data (RTV, TC, TSA) were 0.900, 0.858, 0.771, 0.754, 0.859, the sensitivity were 95.8%, 79.17%, 62.50%, 95.83%, 62.5%, the specificity were 70.9%, 74.55%, 83.64%,47.27%, 96.36%, the positive predictive values were 58.96%, 57.58%, 62.51%,44.23%, 88.23%, the negative predictive values were 97.48%, 89.13%, 83.64%, 96.29%, and 85.48%, respectively.

Published
2020
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2. Analysis of influencing factors of no/low response to preoperative concurrent chemoradiotherapy in locally advanced rectal cancer

Author

Congrong Yang, Yafan Yang, Fengpeng Wu, Jianfeng Zhang, Jun Wang, Guiying Wang, Guanglin Wang, Chaoxi Zhou, and Wenbo Niu

Subjects
0301 basic medicine, Male, Colorectal cancer, Carcinogenesis, medicine.medical_treatment, Cancer Treatment, Logistic regression, Conservative Treatment, Gastroenterology, Biomarkers, Pharmacological, Diagnostic Radiology, Cohort Studies, 0302 clinical medicine, Animal Cells, Cancer Stem Cells, Medicine and Health Sciences, Prospective cohort study, Aged, 80 and over, Multidisciplinary, medicine.diagnostic_test, Frailty, Radiology and Imaging, Stem Cells, Neoplasms, Second Primary, Chemoradiotherapy, Primary tumor, Combined Modality Therapy, Magnetic Resonance Imaging, Tumor Burden, Renal Replacement Therapy, Treatment Outcome, Oncology, 030220 oncology & carcinogenesis, Area Under Curve, Medicine, Female, Anatomy, Cellular Types, Cohort study, Research Article, Clinical Oncology, medicine.medical_specialty, Imaging Techniques, Science, Radiation Therapy, Surgical and Invasive Medical Procedures, Research and Analysis Methods, Sensitivity and Specificity, Rectal Cancer, 03 medical and health sciences, Diagnostic Medicine, Internal medicine, Gastrointestinal Tumors, medicine, Humans, Aged, Retrospective Studies, Tumor Stem Cells, business.industry, Rectal Neoplasms, Rectum, Biology and Life Sciences, Cancers and Neoplasms, Magnetic resonance imaging, Retrospective cohort study, Cell Biology, medicine.disease, Radiation therapy, Gastrointestinal Tract, 030104 developmental biology, ROC Curve, Neoplasm Recurrence, Local, Clinical Medicine, business, Digestive System
Abstract

The aim of this study is to investigate the influencing factors associated with no/low response to preoperative concurrent chemoradiotherapy (CCRT) for locally advanced rectal cancer (LARC) patients. A total of 79 patients were included in this prospective study. Fifteen factors that might affect the resistance to CCRT were included in this logistic regression analysis, these factors include the general clinical data of patients, the expression status of tumor stem cell marker CD44v6 and the volumetric imaging parameters of primary tumor lesions. We found that the no/low response status to preoperative CCRT was positively correlated with the real tumor volume (RTV), the total surface area of tumor (TSA), and CD44v6 expression, whereas negatively correlated with the tumor compactness (TC). According to the results of logistic regression analysis, two formulas that could predict whether or not no/low response to preoperative CCRT were established. The Area Under Curve (AUC) of the two formulas and those significant measurement data (RTV, TC, TSA) were 0.900, 0.858, 0.771, 0.754, 0.859, the sensitivity were 95.8%, 79.17%, 62.50%, 95.83%, 62.5%, the specificity were 70.9%, 74.55%, 83.64%,47.27%, 96.36%, the positive predictive values were 58.96%, 57.58%, 62.51%,44.23%, 88.23%, the negative predictive values were 97.48%, 89.13%, 83.64%, 96.29%, and 85.48%, respectively.

Published
2019

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