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Your search keyword '"VandeBerg, John L."' showing total 7 results
Start Over Author "VandeBerg, John L." Journal plos one
7 results on '"VandeBerg, John L."'

5. Age-Dependent Changes in the Proteome Following Complete Spinal Cord Transection in a Postnatal South American Opossum (Monodelphis domestica)

Author

Noor, Natassya M., primary, Steer, David L., additional, Wheaton, Benjamin J., additional, Ek, C. Joakim, additional, Truettner, Jessie S., additional, Dietrich, W. Dalton, additional, Dziegielewska, Katarzyna M., additional, Richardson, Samantha J., additional, Smith, A. Ian, additional, VandeBerg, John L., additional, and Saunders, Norman R., additional

Published
2011
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6. Dynamics of the Two Heterochromatin Types during Imprinted X Chromosome Inactivation in Vole Microtus levis.

Author

Vaskova, Evgeniya A., Dementyeva, Elena V., Shevchenko, Alexander I., Pavlova, Sophia V., Grigor'eva, Elena V., Zhelezova, Antonina I., VandeBerg, John L., and Zakian, Suren M.

Subjects
HETEROCHROMATIN, MICROTUS, CHROMOSOME abnormalities, LABORATORY rodents, DEVELOPMENTAL biology, MOLECULAR biology, GENE expression
Abstract

In rodent female mammals, there are two forms of X-inactivation – imprinted and random which take place in extraembryonic and embryonic tissues, respectively. The inactive X-chromosome during random X-inactivation was shown to contain two types of facultative heterochromatin that alternate and do not overlap. However, chromatin structure of the inactive X-chromosome during imprinted X-inactivation, especially at early stages, is still not well understood. In this work, we studied chromatin modifications associated with the inactive X-chromosome at different stages of imprinted X-inactivation in a rodent, Microtus levis. It has been found that imprinted X-inactivation in vole occurs in a species-specific manner in two steps. The inactive X-chromosome at early stages of imprinted X-inactivation is characterized by accumulation of H3K9me3, HP1, H4K20me3, and uH2A, resembling to some extent the pattern of repressive chromatin modifications of meiotic sex chromatin. Later, the inactive X-chromosome recruits trimethylated H3K27 and acquires the two types of heterochromatin associated with random X-inactivation. [ABSTRACT FROM AUTHOR]

Published
2014
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7. Dynamics of the Two Heterochromatin Types during Imprinted X Chromosome Inactivation in Vole Microtus levis.

Author

Vaskova, Evgeniya A., Dementyeva, Elena V., Shevchenko, Alexander I., Pavlova, Sophia V., Grigor'eva, Elena V., Zhelezova, Antonina I., VandeBerg, John L., and Zakian, Suren M.

Subjects
*HETEROCHROMATIN, *MICROTUS, *CHROMOSOME abnormalities, *LABORATORY rodents, *DEVELOPMENTAL biology, *MOLECULAR biology, *GENE expression
Abstract

In rodent female mammals, there are two forms of X-inactivation – imprinted and random which take place in extraembryonic and embryonic tissues, respectively. The inactive X-chromosome during random X-inactivation was shown to contain two types of facultative heterochromatin that alternate and do not overlap. However, chromatin structure of the inactive X-chromosome during imprinted X-inactivation, especially at early stages, is still not well understood. In this work, we studied chromatin modifications associated with the inactive X-chromosome at different stages of imprinted X-inactivation in a rodent, Microtus levis. It has been found that imprinted X-inactivation in vole occurs in a species-specific manner in two steps. The inactive X-chromosome at early stages of imprinted X-inactivation is characterized by accumulation of H3K9me3, HP1, H4K20me3, and uH2A, resembling to some extent the pattern of repressive chromatin modifications of meiotic sex chromatin. Later, the inactive X-chromosome recruits trimethylated H3K27 and acquires the two types of heterochromatin associated with random X-inactivation. [ABSTRACT FROM AUTHOR]

Published
2014
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