1. Mitochondrial changes in platelets are not related to those in skeletal muscle during human septic shock.
- Author
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Alessandro Protti, Francesco Fortunato, Maria L Caspani, Mauro Pluderi, Valeria Lucchini, Nadia Grimoldi, Luigi P Solimeno, Gigliola Fagiolari, Patrizia Ciscato, Samis M A Zella, Maurizio Moggio, Giacomo P Comi, and Luciano Gattinoni
- Subjects
Medicine ,Science - Abstract
Platelets can serve as general markers of mitochondrial (dys)function during several human diseases. Whether this holds true even during sepsis is unknown. Using spectrophotometry, we measured mitochondrial respiratory chain biochemistry in platelets and triceps brachii muscle of thirty patients with septic shock (within 24 hours from admission to Intensive Care) and ten surgical controls (during surgery). Results were expressed relative to citrate synthase (CS) activity, a marker of mitochondrial density. Patients with septic shock had lower nicotinamide adenine dinucleotide dehydrogenase (NADH)/CS (p = 0.015), complex I/CS (p = 0.018), complex I and III/CS (p
- Published
- 2014
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