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2. Efficacious Recombinant Influenza Vaccines Produced by High Yield Bacterial Expression: A Solution to Global Pandemic and Seasonal Needs

Author

Song, Langzhou, primary, Nakaar, Valerian, additional, Kavita, Uma, additional, Price, Albert, additional, Huleatt, Jim, additional, Tang, Jie, additional, Jacobs, Andrea, additional, Liu, Ge, additional, Huang, Yan, additional, Desai, Priyanka, additional, Maksymiuk, Gail, additional, Takahashi, Virginia, additional, Umlauf, Scott, additional, Reiserova, Lucia, additional, Bell, Rodney, additional, Li, Hong, additional, Zhang, Yi, additional, McDonald, William F., additional, Powell, T. J., additional, and Tussey, Lynda, additional

Published
2008
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3. Efficacious Recombinant Influenza Vaccines Produced by High Yield Bacterial Expression: A Solution to Global Pandemic and Seasonal Needs.

Author

Langzhou Song, Nakaar, Valerian, Kavita, Uma, Price, Albert, Huleatt, Jim, Jie Tang, Jacobs, Andrea, Ge Liu, Yan Huang, Desai, Priyanka, Maksymiuk, Gail, Takahashi, Virginia, Umlauf, Scott, Reiserova, Lucia, Bell, Rodney, Hong Li, Yi Zhang, McDonald, William F., Powell, T. J., and Tussey, Lynda

Subjects
INFLUENZA vaccines, LIGANDS (Biochemistry), ANTIGENS, IMMUNOLOGICAL adjuvants, HEMAGGLUTININ, HUMAN genetic variation, ESCHERICHIA coli, FERMENTATION, PANDEMICS
Abstract

It is known that physical linkage of TLR ligands and vaccine antigens significantly enhances the immunopotency of the linked antigens. We have used this approach to generate novel influenza vaccines that fuse the globular head domain of the protective hemagglutinin (HA) antigen with the potent TLR5 ligand, flagellin. These fusion proteins are efficiently expressed in standard E. coli fermentation systems and the HA moiety can be faithfully refolded to take on the native conformation of the globular head. In mouse models of influenza infection, the vaccines elicit robust antibody responses that mitigate disease and protect mice from lethal challenge. These immunologically potent vaccines can be efficiently manufactured to support pandemic response, pre-pandemic and seasonal vaccines. [ABSTRACT FROM AUTHOR]

Published
2008
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