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1. A voxel-based analysis of cerebral blood flow abnormalities in obsessive-compulsive disorder using pseudo-continuous arterial spin labeling MRI.

Author

Daichi Momosaka, Osamu Togao, Akio Hiwatashi, Koji Yamashita, Kazufumi Kikuchi, Hirofumi Tomiyama, Tomohiro Nakao, Keitaro Murayama, Yuriko Suzuki, and Hiroshi Honda

Subjects
Medicine, Science
Abstract

ObjectiveTo identify abnormalities of regional cerebral blood flow (rCBF) in individuals with obsessive-compulsive disorder (OCD) by conducting a voxel-based analysis of pseudo-continuous arterial spin labeling (pCASL) perfusion images.Materials and methodsThis prospective study included 23 OCD patients (nine males, 14 females; age 21-62 years; mean ± SD 37.2 ± 10.7 years) diagnosed based on DSM-IV-TR criteria and 64 healthy controls (27 males, 37 females; age 20-64 years; mean ± SD 38.3 ± 12.8 years). Subjects were recruited from October 2011 to August 2017. Imaging was performed on a 3T scanner. Quantitative rCBF maps generated from pCASL images were co-registered and resliced with the three-dimensional T1-weighted images, and then spatially normalized to a brain template and smoothed. We used statistical nonparametric mapping to assess the differences in rCBF and gray matter volume between the OCD and control groups. The significance level was set at the p-value ResultsCompared to the control group, there were significant rCBF reductions in the right putamen, right frontal operculum, left midcingulate cortex, and right temporal pole in the OCD group. There were no significant between-group differences in the gray matter volume.ConclusionThe pCASL imaging noninvasively detected physiologically disrupted areas without structural abnormalities in OCD patients. The rCBF reductions observed in these regions in OCD patients could be associated with the pathophysiology of OCD.

Published
2020
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2. A unique increase in prefrontal gray matter volume in hoarding disorder compared to obsessive-compulsive disorder.

Author

Satoshi Yamada, Tomohiro Nakao, Keisuke Ikari, Masumi Kuwano, Keitaro Murayama, Hirofumi Tomiyama, Suguru Hasuzawa, Osamu Togao, Akio Hiwatashi, and Shigenobu Kanba

Subjects
Medicine, Science
Abstract

BACKGROUND:Hoarding disorder (HD) is a disease concept newly presented in DSM-5. As far as we know, no studies have examined the structural changes relevant to hoarding by applying the diagnostic criteria of HD in DSM-5. In the present study, we aimed to find abnormalities in gray matter (GM) structures of patients with HD. METHODS:Seventeen patients who met the DSM-5 criteria for HD, 17 obsessive-compulsive disorder (OCD) patients, and 17 healthy controls (HCs) participated in this study. All participants underwent MRI scanning of the brain by a 3.0-Tesla MRI scanner. In a voxel-based morphometric procedure, preprocessed GM structural images were used to compare the three groups. Thereafter we investigated the correlation between the clinical data (age of onset, symptomatic severity) and GM volume. RESULTS:The HD group showed a significantly increased GM volume compared to the OCD and healthy control groups (p

Published
2018
Full Text
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3. A voxel-based analysis of cerebral blood flow abnormalities in obsessive-compulsive disorder using pseudo-continuous arterial spin labeling MRI

Author

Hirofumi Tomiyama, Kazufumi Kikuchi, Koji Yamashita, Yuriko Suzuki, Akio Hiwatashi, Keitaro Murayama, Hiroshi Honda, Daichi Momosaka, Tomohiro Nakao, and Osamu Togao

Subjects
Male, Central Nervous System, Obsessive-Compulsive Disorder, computer.software_genre, Brain mapping, Nervous System, Diagnostic Radiology, 0302 clinical medicine, Voxel, Functional Magnetic Resonance Imaging, Image Processing, Computer-Assisted, Medicine and Health Sciences, Prospective Studies, Prospective cohort study, Brain Mapping, Multidisciplinary, medicine.diagnostic_test, Radiology and Imaging, Brain, Arteries, Middle Aged, Magnetic Resonance Imaging, Anxiety Disorders, Diffusion Tensor Imaging, Cerebral blood flow, Cerebrovascular Circulation, Medicine, Female, Anatomy, Perfusion, Research Article, Adult, Imaging Techniques, Science, Brain Morphometry, Neuropsychiatric Disorders, Neuroimaging, Neuroses, Research and Analysis Methods, 03 medical and health sciences, Young Adult, Imaging, Three-Dimensional, Diagnostic Medicine, Echo Planar Imaging, Arterial Spin Labelling, mental disorders, Mental Health and Psychiatry, medicine, Humans, Behavioral Disorders, business.industry, Morphometry, Biology and Life Sciences, Magnetic resonance imaging, Voxel-based morphometry, 030227 psychiatry, Case-Control Studies, Spin Labels, Nuclear medicine, business, computer, Voxel-Based Morphometry, 030217 neurology & neurosurgery, Diffusion MRI, Neuroscience
Abstract

ObjectiveTo identify abnormalities of regional cerebral blood flow (rCBF) in individuals with obsessive-compulsive disorder (OCD) by conducting a voxel-based analysis of pseudo-continuous arterial spin labeling (pCASL) perfusion images.Materials and methodsThis prospective study included 23 OCD patients (nine males, 14 females; age 21-62 years; mean ± SD 37.2 ± 10.7 years) diagnosed based on DSM-IV-TR criteria and 64 healthy controls (27 males, 37 females; age 20-64 years; mean ± SD 38.3 ± 12.8 years). Subjects were recruited from October 2011 to August 2017. Imaging was performed on a 3T scanner. Quantitative rCBF maps generated from pCASL images were co-registered and resliced with the three-dimensional T1-weighted images, and then spatially normalized to a brain template and smoothed. We used statistical nonparametric mapping to assess the differences in rCBF and gray matter volume between the OCD and control groups. The significance level was set at the p-value ResultsCompared to the control group, there were significant rCBF reductions in the right putamen, right frontal operculum, left midcingulate cortex, and right temporal pole in the OCD group. There were no significant between-group differences in the gray matter volume.ConclusionThe pCASL imaging noninvasively detected physiologically disrupted areas without structural abnormalities in OCD patients. The rCBF reductions observed in these regions in OCD patients could be associated with the pathophysiology of OCD.

Published
2020

4. A unique increase in prefrontal gray matter volume in hoarding disorder compared to obsessive-compulsive disorder

Author

Keisuke Ikari, Akio Hiwatashi, Satoshi Yamada, Shigenobu Kanba, Suguru Hasuzawa, Keitaro Murayama, Masumi Kuwano, Osamu Togao, Hirofumi Tomiyama, and Tomohiro Nakao

Subjects
Central Nervous System, Male, Obsessive-Compulsive Disorder, lcsh:Medicine, Nervous System, Brain mapping, Diagnostic Radiology, Mathematical and Statistical Techniques, Hoarding Disorder, 0302 clinical medicine, Medicine and Health Sciences, Image Processing, Computer-Assisted, Age of Onset, Gray Matter, lcsh:Science, Brain Mapping, Multidisciplinary, medicine.diagnostic_test, Depression, Radiology and Imaging, Brain, Middle Aged, Anxiety Disorders, Magnetic Resonance Imaging, 3. Good health, Physical Sciences, Female, Anatomy, medicine.symptom, Statistics (Mathematics), Research Article, Brodmann area, Adult, medicine.medical_specialty, Imaging Techniques, Brain Morphometry, Neuropsychiatric Disorders, Neuroimaging, Neuroses, Research and Analysis Methods, behavioral disciplines and activities, 03 medical and health sciences, Diagnostic Medicine, Internal medicine, Mental Health and Psychiatry, mental disorders, medicine, Humans, Hoarding disorder, Statistical Methods, Analysis of Variance, Behavior, Behavioral Disorders, Mood Disorders, business.industry, Morphometry, lcsh:R, Case-control study, Biology and Life Sciences, Magnetic resonance imaging, Voxel-based morphometry, 030227 psychiatry, Case-Control Studies, Linear Models, lcsh:Q, Age of onset, business, Voxel-Based Morphometry, Mathematics, 030217 neurology & neurosurgery, Neuroscience
Abstract

Background Hoarding disorder (HD) is a disease concept newly presented in DSM-5. As far as we know, no studies have examined the structural changes relevant to hoarding by applying the diagnostic criteria of HD in DSM-5. In the present study, we aimed to find abnormalities in gray matter (GM) structures of patients with HD. Methods Seventeen patients who met the DSM-5 criteria for HD, 17 obsessive-compulsive disorder (OCD) patients, and 17 healthy controls (HCs) participated in this study. All participants underwent MRI scanning of the brain by a 3.0-Tesla MRI scanner. In a voxel-based morphometric procedure, preprocessed GM structural images were used to compare the three groups. Thereafter we investigated the correlation between the clinical data (age of onset, symptomatic severity) and GM volume. Results The HD group showed a significantly increased GM volume compared to the OCD and healthy control groups (p

Published
2018

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