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Your search keyword '"Susan L Koletar"' showing total 3 results
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1. HIV Infection Is Associated with Increased Fatty Infiltration of the Thigh Muscle with Aging Independent of Fat Distribution.

Author

Javzandulam Natsag, Kristine M Erlandson, Deborah E Sellmeyer, Sabina A Haberlen, Joseph Margolick, Lisa P Jacobson, Frank J Palella, Susan L Koletar, Jordan E Lake, Wendy S Post, and Todd T Brown

Subjects
Medicine, Science
Abstract

BACKGROUND:Lower muscle density on computed tomography (CT) provides a measure of fatty infiltration of muscle, an aspect of muscle quality that has been associated with metabolic abnormalities, weakness, decreased mobility, and increased fracture risk in older adults. We assessed the cross-sectional relationship between HIV serostatus, age, thigh muscle attenuation, and thigh muscle cross-sectional area (CSA). METHODS:Mean CT-quantified Hounsfield units (HU) of the thigh muscle bundle and CSA were evaluated in 368 HIV-infected and 145 HIV-uninfected men enrolled in the Multicenter AIDS Cohort Study (MACS) Cardiovascular Substudy using multivariable linear regression. Models all were adjusted for HIV serostatus, age, race, and body mass index (BMI); each model was further adjusted for covariates that differed by HIV serostatus, including insulin resistance, hepatitis C, malignancy, smoking, alcohol use, and self-reported limitation in physical activity. RESULTS:HIV-infected men had greater thigh muscle CSA (p

Published
2017
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2. Brief report: Circulating markers of fibrosis are associated with immune reconstitution status in HIV-infected men

Author

Otoniel Martinez-Maza, Frank J. Palella, F. A. Tobolowsky, Larry Magpantay, Susan L. Koletar, Todd T. Brown, Nikolas Wada, and Jordan E. Lake

Subjects
0301 basic medicine, Male, RNA viruses, Multicenter AIDS Cohort Study, HIV Infections, Platelet Factor 4, Pathology and Laboratory Medicine, Biochemistry, Cryopreservation, chemistry.chemical_compound, White Blood Cells, 0302 clinical medicine, Immunodeficiency Viruses, Fibrosis, Animal Cells, Hyaluronic acid, Medicine and Health Sciences, Public and Occupational Health, 030212 general & internal medicine, Hyaluronic Acid, Immune Response, Multidisciplinary, T Cells, HIV diagnosis and management, Middle Aged, Vaccination and Immunization, 3. Good health, Lymphatic system, Medical Microbiology, Viral Pathogens, Viruses, Infectious diseases, Medicine, Cellular Types, Pathogens, Research Article, Anti-HIV Agents, Lymphoid Tissue, Immune Cells, Science, Immunology, Antiretroviral Therapy, Viral diseases, Microbiology, Andrology, 03 medical and health sciences, Immune system, Antiviral Therapy, Retroviruses, medicine, Humans, Microbial Pathogens, Blood Cells, business.industry, Lentivirus, Organisms, Biology and Life Sciences, HIV, T lymphocyte, Cell Biology, medicine.disease, Diagnostic medicine, CD4 Lymphocyte Count, 030104 developmental biology, chemistry, HIV-1, Preventive Medicine, business, Platelet factor 4, Biomarkers, Developmental Biology
Abstract

IntroductionLymphoid tissue fibrosis may contribute to incomplete immune reconstitution on antiretroviral therapy (ART) via local CD4+ T lymphocyte (CD4) depletion. Hyaluronic acid (HA) increases with fibrotic burden. CXCL4 concentrations increase in response to pro-fibrotic stimuli, but lower CXCL4 concentrations in HIV-infected individuals may reflect successful immune evasion by HIV. We investigated relationships between circulating HA and CXCL4 concentrations and immune reconstitution on ART in HIV-infected Multicenter AIDS Cohort Study participants.MethodsHIV-infected men on ART for >1 year with cryopreserved plasma samples and suppressed post-ART HIV-1 RNA were included. Men with post-ART CD4 500 cells/mm3 served as controls (n = 49). HA and CXCL4 concentrations were measured via ELISA.ResultsMedian pre-ART CD4 was 297 cells/mm3 for non-responders vs 386 cells/mm3 for controls. Median post-ART CD4 was 141 cells/mm3 for non-responders and 815 cells/mm3 for controls. HIV infection duration was 23 years, with median time on ART 13 years for non-responders vs 11 years for controls. Pre-ART HA and CXCL4 concentrations did not vary by eventual immune reconstitution status. Post-ART HA concentrations tended to be higher (85 vs 36 ng/mL, p = 0.07) and CXCL4 concentrations were lower (563 vs 1459 ng/mL, p = 0.01) among non-responders. Among men with paired pre-/post-ART samples, non-responders had greater HA increases and CXCL4 decreases than controls (HA: 50 vs 12 ng/mL, p = 0.04; CXCL4: -1258 vs -405 ng/mL, p = 0.01).ConclusionsHigher circulating concentrations of HA and lower concentrations of CXCL4 are associated with failure of immune reconstitution on ART.

Published
2018

3. HIV Infection Is Associated with Increased Fatty Infiltration of the Thigh Muscle with Aging Independent of Fat Distribution

Author

Jordan E. Lake, Deborah E. Sellmeyer, Kristine M. Erlandson, Susan L. Koletar, Wendy S. Post, Frank J. Palella, Sabina A. Haberlen, Joseph B. Margolick, Lisa P. Jacobson, Todd T. Brown, and Javzandulam Natsag

Subjects
Male, RNA viruses, Aging, Muscle Physiology, Muscle Functions, Physiology, Multicenter AIDS Cohort Study, lcsh:Medicine, HIV Infections, Thigh, Pathology and Laboratory Medicine, Gastroenterology, Biochemistry, Diagnostic Radiology, Cohort Studies, Fats, 0302 clinical medicine, Immunodeficiency Viruses, Medicine and Health Sciences, 030212 general & internal medicine, lcsh:Science, Musculoskeletal System, Tomography, 2. Zero hunger, Multidisciplinary, Alcohol Consumption, Muscles, Radiology and Imaging, virus diseases, Hepatitis C, Muscle Analysis, Middle Aged, Lipids, 3. Good health, medicine.anatomical_structure, Bioassays and Physiological Analysis, Medical Microbiology, Viral Pathogens, Viruses, Body Composition, Female, medicine.symptom, Pathogens, Anatomy, Research Article, Adult, Weakness, medicine.medical_specialty, Imaging Techniques, Subcutaneous Fat, Muscle Tissue, 030209 endocrinology & metabolism, Neuroimaging, Research and Analysis Methods, Microbiology, 03 medical and health sciences, Insulin resistance, Diagnostic Medicine, Internal medicine, Retroviruses, medicine, Humans, Risk factor, Muscle, Skeletal, Microbial Pathogens, Nutrition, business.industry, Lentivirus, lcsh:R, Organisms, Biology and Life Sciences, HIV, medicine.disease, Lipid Metabolism, Surgery, Diet, Computed Axial Tomography, Biological Tissue, Skeletal Muscles, lcsh:Q, Serostatus, business, Body mass index, Neuroscience
Abstract

BACKGROUND Lower muscle density on computed tomography (CT) provides a measure of fatty infiltration of muscle, an aspect of muscle quality that has been associated with metabolic abnormalities, weakness, decreased mobility, and increased fracture risk in older adults. We assessed the cross-sectional relationship between HIV serostatus, age, thigh muscle attenuation, and thigh muscle cross-sectional area (CSA). METHODS Mean CT-quantified Hounsfield units (HU) of the thigh muscle bundle and CSA were evaluated in 368 HIV-infected and 145 HIV-uninfected men enrolled in the Multicenter AIDS Cohort Study (MACS) Cardiovascular Substudy using multivariable linear regression. Models all were adjusted for HIV serostatus, age, race, and body mass index (BMI); each model was further adjusted for covariates that differed by HIV serostatus, including insulin resistance, hepatitis C, malignancy, smoking, alcohol use, and self-reported limitation in physical activity. RESULTS HIV-infected men had greater thigh muscle CSA (p

Published
2017

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