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10 results on '"Sipos, Bence"'

4. Comparative Characterization of Stroma Cells and Ductal Epithelium in Chronic Pancreatitis and Pancreatic Ductal Adenocarcinoma

Author

Helm, Ole, primary, Mennrich, Ruben, additional, Petrick, Domantas, additional, Goebel, Lisa, additional, Freitag-Wolf, Sandra, additional, Röder, Christian, additional, Kalthoff, Holger, additional, Röcken, Christoph, additional, Sipos, Bence, additional, Kabelitz, Dieter, additional, Schäfer, Heiner, additional, Oberg, Hans-Heinrich, additional, Wesch, Daniela, additional, and Sebens, Susanne, additional

Published
2014
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5. Metabolic Signature of Electrosurgical Liver Dissection

Author

von Schönfels, Witigo, primary, von Kampen, Oliver, additional, Patsenker, Eleonora, additional, Stickel, Felix, additional, Schniewind, Bodo, additional, Hinz, Sebastian, additional, Ahrens, Markus, additional, Balschun, Katharina, additional, Egberts, Jan-Hendrik, additional, Richter, Klaus, additional, Landrock, Andreas, additional, Sipos, Bence, additional, Will, Olga, additional, Huebbe, Patrizia, additional, Schreiber, Stefan, additional, Nothnagel, Michael, additional, Röcken, Christoph, additional, Rimbach, Gerald, additional, Becker, Thomas, additional, Hampe, Jochen, additional, and Schafmayer, Clemens, additional

Published
2013
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7. Prognostic Significance of Erythropoietin in Pancreatic Adenocarcinoma

Author

Welsch, Thilo, primary, Zschäbitz, Stefanie, additional, Becker, Verena, additional, Giese, Thomas, additional, Bergmann, Frank, additional, Hinz, Ulf, additional, Keleg, Shereen, additional, Heller, Anette, additional, Sipos, Bence, additional, Klingmüller, Ursula, additional, Büchler, Markus W., additional, Werner, Jens, additional, and Giese, Nathalia A., additional

Published
2011
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9. Examination of Apoptosis Signaling in Pancreatic Cancer by Computational Signal Transduction Analysis

Author

Rückert, Felix, primary, Dawelbait, Gihan, additional, Winter, Christof, additional, Hartmann, Arndt, additional, Denz, Axel, additional, Ammerpohl, Ole, additional, Schroeder, Michael, additional, Schackert, Hans Konrad, additional, Sipos, Bence, additional, Klöppel, Günter, additional, Kalthoff, Holger, additional, Saeger, Hans-Detlev, additional, Pilarsky, Christian, additional, and Grützmann, Robert, additional

Published
2010
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10. Identification of Epidermal Pdx1 Expression Discloses Different Roles of Notch1 and Notch2 in Murine KrasG12D-Induced Skin Carcinogenesis In Vivo.

Author

Mazur, Pawel K., Grüner, Barbara M., Nakhai, Hassan, Sipos, Bence, Zimber-Strobl, Ursula, Strobl, Lothar J., Radtke, Freddy, Schmid, Roland M., and Siveke, Jens T.

Subjects
EPIDERMIS, CELL populations, NOTCH genes, CARCINOGENESIS, ANIMAL models in research, TRANSGENIC mice, ONCOGENIC viruses, PAPILLOMA, SQUAMOUS cell carcinoma, GENETIC engineering
Abstract

Background: The Ras and Notch signaling pathways are frequently activated during development to control many diverse cellular processes and are often dysregulated during tumorigenesis. To study the role of Notch and oncogenic Kras signaling in a progenitor cell population, Pdx1-Cre mice were utilized to generate conditional oncogenic KrasG12D mice with ablation of Notch1 and/or Notch2. Methodology/Principal Findings: Surprisingly, mice with activated KrasG12D and Notch1 but not Notch2 ablation developed skin papillomas progressing to squamous cell carcinoma providing evidence for Pdx1 expression in the skin. Immunostaining and lineage tracing experiments indicate that PDX1 is present predominantly in the suprabasal layers of the epidermis and rarely in the basal layer. Further analysis of keratinocytes in vitro revealed differentiation-dependent expression of PDX1 in terminally differentiated keratinocytes. PDX1 expression was also increased during wound healing. Further analysis revealed that loss of Notch1 but not Notch2 is critical for skin tumor development. Reasons for this include distinct Notch expression with Notch1 in all layers and Notch2 in the suprabasal layer as well as distinctive p21 and bcatenin signaling inhibition capabilities. Conclusions/Significance: Our results provide strong evidence for epidermal expression of Pdx1 as of yet not identified function. In addition, this finding may be relevant for research using Pdx1-Cre transgenic strains. Additionally, our study confirms distinctive expression and functions of Notch1 and Notch2 in the skin supporting the importance of careful dissection of the contribution of individual Notch receptors. [ABSTRACT FROM AUTHOR]

Published
2010
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