1. Association of Forced Vital Capacity with the Developmental Gene NCOR2
- Author
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Minelli, Cosetta, Dean, Charlotte H, Hind, Matthew, Alves, Alexessander Couto, Amaral, André FS, Siroux, Valerie, Huikari, Ville, Soler Artigas, María, Evans, David M, Loth, Daan W, Bossé, Yohan, Postma, Dirkje S, Sin, Don, Thompson, John, Demenais, Florence, Henderson, John, Bouzigon, Emmanuelle, Jarvis, Deborah, Järvelin, Marjo-Riitta, and Burney, Peter
- Subjects
Biological Sciences ,Biomedical and Clinical Sciences ,Genetics ,Epidemiology ,Health Sciences ,Lung ,Clinical Research ,2.1 Biological and endogenous factors ,Aetiology ,Respiratory ,Adult ,Aged ,Female ,Forced Expiratory Volume ,Gene Expression Profiling ,Genes ,Developmental ,Genetic Association Studies ,Genome-Wide Association Study ,Humans ,Male ,Middle Aged ,Nuclear Receptor Co-Repressor 2 ,Organogenesis ,Polymorphism ,Single Nucleotide ,Quantitative Trait Loci ,Young Adult ,SpiroMeta consortium ,CHARGE consortium ,General Science & Technology - Abstract
BackgroundForced Vital Capacity (FVC) is an important predictor of all-cause mortality in the absence of chronic respiratory conditions. Epidemiological evidence highlights the role of early life factors on adult FVC, pointing to environmental exposures and genes affecting lung development as risk factors for low FVC later in life. Although highly heritable, a small number of genes have been found associated with FVC, and we aimed at identifying further genetic variants by focusing on lung development genes.MethodsPer-allele effects of 24,728 SNPs in 403 genes involved in lung development were tested in 7,749 adults from three studies (NFBC1966, ECRHS, EGEA). The most significant SNP for the top 25 genes was followed-up in 46,103 adults (CHARGE and SpiroMeta consortia) and 5,062 children (ALSPAC). Associations were considered replicated if the replication p-value survived Bonferroni correction (p
- Published
- 2016