9 results on '"Shuo-Ming Ou"'
Search Results
2. TLR4/CD14 Variants-Related Serologic and Immunologic Dys-Regulations Predict Severe Sepsis in Febrile De-Compensated Cirrhotic Patients.
- Author
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Wen-Chien Fan, Chih-Wei Liu, Shuo-Ming Ou, Chia-Chang Huang, Tzu-Hao Li, Kuei-Chuan Lee, Shiang-Fen Huang, Ying-Ying Yang, Yun-Cheng Hsieh, Shie-Liang Hsieh, Ming-Chih Hou, and Han-Chieh Lin
- Subjects
Medicine ,Science - Abstract
Genetic variants and dysfunctional monocyte had been reported to be associated with infection susceptibility in advanced cirrhotic patients. This study aims to explore genetic predictive markers and relevant immune dysfunction that contributed to severe sepsis in febrile acute de-compensated cirrhotic patents. Polymorphism analysis of candidate genes was undergone in 108 febrile acute de-compensated cirrhotic patients and 121 healthy volunteers. Various plasma inflammatory/regulatory cytokines, proportion of classical (CD 16-, phagocytic) and non-classical (CD16+, inflammatory) monocytes, lipopolysaccharide (LPS)-stimulated toll-like receptor 4 (TLR4) and intracellular/extracellular cytokines on cultured non-classical monocytes, mCD14/HLA-DR expression and phagocytosis of classical monocytes were measured. For TLR4+896A/G variant allele carriers with severe sepsis, high plasma endotoxin/IL-10 inhibits HLA-DR expression and impaired phagocytosis were noted in their classical monocyte. In the same group, increased non-classical monocyte subset, enhanced LPS-stimulated TLR4 expression and TNFα/nitrite production, and systemic inflammation [high plasma soluble CD14 (sCD14) and total nitric oxide (NOx) levels] were noted. For CD14-159C/T variant allele carriers with severe sepsis, persist endotoxemia inhibited mCD14/HLA-DR expression and impaired phagocytosis of their classical monocyte. In the same group, increased non-classical monocyte subset up-regulated TLR4-NFκB-iNOS and p38MAPK pathway, stimulated TNFα/nitrite production and elicited systemic inflammation. In febrile acute de-compensated cirrhotic patients, TLR4+896A/G and CD14-159C/T polymorphisms-related non-classical and classical monocytes dysfunction resulted in increased severe sepsis risk. Malnutrition, high plasma endotoxin and sCD14 levels, single TLR4+896A/G or CD14-159C/T variant allele carriers and double variant allele carriers are significant predictive factors for the development of severe sepsis among them.
- Published
- 2016
- Full Text
- View/download PDF
3. Diagnostic Accuracy of Urine Protein/Creatinine Ratio Is Influenced by Urine Concentration.
- Author
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Chih-Yu Yang, Fu-An Chen, Chun-Fan Chen, Wen-Sheng Liu, Chia-Jen Shih, Shuo-Ming Ou, Wu-Chang Yang, Chih-Ching Lin, and An-Hang Yang
- Subjects
Medicine ,Science - Abstract
The usage of urine protein/creatinine ratio to estimate daily urine protein excretion is prevalent, but relatively little attention has been paid to the influence of urine concentration and its impact on test accuracy. We took advantage of 24-hour urine collection to examine both urine protein/creatinine ratio (UPCR) and daily urine protein excretion, with the latter as the reference standard. Specific gravity from a concomitant urinalysis of the same urine sample was used to indicate the urine concentration.During 2010 to 2014, there were 540 adequately collected 24h urine samples with protein concentration, creatinine concentration, total volume, and a concomitant urinalysis of the same sample. Variables associated with an accurate UPCR estimation were determined by multivariate linear regression analysis. Receiver operating characteristic (ROC) curves were generated to determine the discriminant cut-off values of urine creatinine concentration for predicting an accurate UPCR estimation in either dilute or concentrated urine samples.Our findings indicated that for dilute urine, as indicated by a low urine specific gravity, UPCR is more likely to overestimate the actual daily urine protein excretion. On the contrary, UPCR of concentrated urine is more likely to result in an underestimation. By ROC curve analysis, the best cut-off value of urine creatinine concentration for predicting overestimation by UPCR of dilute urine (specific gravity ≦ 1.005) was ≦ 38.8 mg/dL, whereas the best cut-off values of urine creatinine for predicting underestimation by UPCR of thick urine were ≧ 63.6 mg/dL (specific gravity ≧ 1.015), ≧ 62.1 mg/dL (specific gravity ≧ 1.020), ≧ 61.5 mg/dL (specific gravity ≧ 1.025), respectively. We also compared distribution patterns of urine creatinine concentration of 24h urine cohort with a concurrent spot urine cohort and found that the underestimation might be more profound in single voided samples.The UPCR in samples with low or high specific gravity is more likely to overestimate or underestimate actual daily urine protein amount, respectively, especially in a dilute urine sample with its creatinine below 38.8 mg/dL or a concentrated sample with its creatinine above 61.5 mg/dL. In particular, UPCR results should be interpreted with caution in cases that involve dilute urine samples because its overestimation may lead to an erroneous diagnosis of proteinuric renal disease or an incorrect staging of chronic kidney disease.
- Published
- 2015
- Full Text
- View/download PDF
4. The effect of cold temperature on increased exacerbation of chronic obstructive pulmonary disease: a nationwide study.
- Author
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Ching-Min Tseng, Yung-Tai Chen, Shuo-Ming Ou, Yi-Han Hsiao, Szu-Yuan Li, Shuu-Jiun Wang, Albert C Yang, Tzeng-Ji Chen, and Diahn-Warng Perng
- Subjects
Medicine ,Science - Abstract
BACKGROUND: Seasonal variations in the acute exacerbation of chronic obstructive pulmonary disease (COPD) have been reported. However, the influence of air temperature and other meteorological factors on COPD exacerbation remains unclear. METHODS: National Health Insurance registry data from January 1, 1999 to December 1, 2009 and meteorological variables from the Taiwan Central Weather Bureau for the same period were analyzed. A case-crossover study design was used to investigate the association between COPD exacerbation and meteorological variables. RESULTS: A total of 16,254 cases who suffered from COPD exacerbation were enrolled. We found that a 1°C decrease in air temperature was associated with a 0.8% increase in the exacerbation rate on event-days (95% confidence interval (CI), 1.015-1.138, p = 0.015). With a 5°C decrease in mean temperature, the cold temperature (28-day average temperature) had a long-term effect on the exacerbation of COPD (odds ratio (OR), 1.106, 95% CI 1.063-1.152, p
- Published
- 2013
- Full Text
- View/download PDF
5. The risk of cancer in patients with generalized anxiety disorder: a nationwide population-based study.
- Author
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Cheng-Che Shen, Yu-Wen Hu, Li-Yu Hu, Man-Hsin Hung, Tung-Ping Su, Min-Wei Huang, Chia-Fen Tsai, Shuo-Ming Ou, Sang-Hue Yen, Cheng-Hwai Tzeng, Tzeon-Jye Chiou, Tzeng-Ji Chen, and Chia-Jen Liu
- Subjects
Medicine ,Science - Abstract
OBJECTIVE: To evaluate the risk of cancer among patients with generalized anxiety disorder (GAD) in a nationwide population-based dataset. METHODS: We recruited newly-diagnosed GAD patients aged 20 years or older without antecedent cancer from the Taiwan National Health Insurance Research database between 2000-2010. Standardized incidence ratios (SIRs) of cancers were calculated in GAD patients, and the subgroup of GAD patients diagnosed by psychiatric specialists. RESULTS: A total of 559 cancers developed among 19,793 GAD patients with a follow-up of 89,485 person-years (median follow-up of 4.34 years), leading to a significantly increased SIR of 1.14 [95% confidence interval (CI) 1.05-1.24]. Male GAD patients had a significantly increased SIR overall (1.30, 95% CI 1.15-1.46) and for lung and prostate cancer (1.77, 95% CI 1.33-2.30 and 2.17, 95% CI 1.56-2.93, respectively). Patients over 80 years of age also had a significantly increased SIR (1.56, 95% CI 1.25-1.92), especially in males. However, psychiatrist-diagnosed GAD patients did not show increased cancer risk relative to the general population, perhaps due to having fewer physical comorbidities than non-psychiatrist-diagnosed GAD patients. CONCLUSION: This study found that overall cancer risk is elevated among patients with GAD. The risk of lung and prostate cancer also increased in male patients with GAD. This increased cancer risk may be due to physical comorbidities and surveillance bias. Further prospective study is necessary to confirm these findings.
- Published
- 2013
- Full Text
- View/download PDF
6. TLR4/CD14 Variants-Related Serologic and Immunologic Dys-Regulations Predict Severe Sepsis in Febrile De-Compensated Cirrhotic Patients
- Author
-
Shie-Liang Hsieh, Tzu-Hao Li, Kuei-Chuan Lee, Wen-Chien Fan, Ying-Ying Yang, Yun-Cheng Hsieh, Chia Chang Huang, Ming-Chih Hou, Chih-Wei Liu, Han-Chieh Lin, Shuo-Ming Ou, and Shiang-Fen Huang
- Subjects
0301 basic medicine ,Liver Cirrhosis ,Male ,Lipopolysaccharide ,Lipopolysaccharide Receptors ,lcsh:Medicine ,Gene Expression ,Systemic inflammation ,Pathology and Laboratory Medicine ,Toxicology ,Immune Receptors ,Biochemistry ,Monocytes ,chemistry.chemical_compound ,White Blood Cells ,0302 clinical medicine ,Animal Cells ,Medicine and Health Sciences ,Toxins ,lcsh:Science ,Toll-like Receptors ,Immune Response ,Aged, 80 and over ,Phagocytes ,Multidisciplinary ,Immune System Proteins ,Middle Aged ,Prognosis ,medicine.anatomical_structure ,Cell Processes ,Cytokines ,030211 gastroenterology & hepatology ,Tumor necrosis factor alpha ,Female ,medicine.symptom ,Cellular Types ,Inflammation Mediators ,Research Article ,Signal Transduction ,Adult ,Fever ,Genotype ,CD14 ,Immune Cells ,Immunology ,Toxic Agents ,Bacterial Toxins ,Inflammation ,Models, Biological ,Polymorphism, Single Nucleotide ,Sepsis ,03 medical and health sciences ,Signs and Symptoms ,Phagocytosis ,Diagnostic Medicine ,medicine ,Genetics ,Humans ,Alleles ,Aged ,Blood Cells ,business.industry ,Monocyte ,lcsh:R ,Biology and Life Sciences ,Proteins ,Genetic Variation ,Cell Biology ,medicine.disease ,Endotoxins ,Toll-Like Receptor 4 ,030104 developmental biology ,chemistry ,Severe Sepsis ,Genetic Loci ,TLR4 ,lcsh:Q ,business ,Biomarkers - Abstract
Genetic variants and dysfunctional monocyte had been reported to be associated with infection susceptibility in advanced cirrhotic patients. This study aims to explore genetic predictive markers and relevant immune dysfunction that contributed to severe sepsis in febrile acute de-compensated cirrhotic patents. Polymorphism analysis of candidate genes was undergone in 108 febrile acute de-compensated cirrhotic patients and 121 healthy volunteers. Various plasma inflammatory/regulatory cytokines, proportion of classical (CD 16-, phagocytic) and non-classical (CD16+, inflammatory) monocytes, lipopolysaccharide (LPS)-stimulated toll-like receptor 4 (TLR4) and intracellular/extracellular cytokines on cultured non-classical monocytes, mCD14/HLA-DR expression and phagocytosis of classical monocytes were measured. For TLR4+896A/G variant allele carriers with severe sepsis, high plasma endotoxin/IL-10 inhibits HLA-DR expression and impaired phagocytosis were noted in their classical monocyte. In the same group, increased non-classical monocyte subset, enhanced LPS-stimulated TLR4 expression and TNFα/nitrite production, and systemic inflammation [high plasma soluble CD14 (sCD14) and total nitric oxide (NOx) levels] were noted. For CD14-159C/T variant allele carriers with severe sepsis, persist endotoxemia inhibited mCD14/HLA-DR expression and impaired phagocytosis of their classical monocyte. In the same group, increased non-classical monocyte subset up-regulated TLR4-NFκB-iNOS and p38MAPK pathway, stimulated TNFα/nitrite production and elicited systemic inflammation. In febrile acute de-compensated cirrhotic patients, TLR4+896A/G and CD14-159C/T polymorphisms-related non-classical and classical monocytes dysfunction resulted in increased severe sepsis risk. Malnutrition, high plasma endotoxin and sCD14 levels, single TLR4+896A/G or CD14-159C/T variant allele carriers and double variant allele carriers are significant predictive factors for the development of severe sepsis among them.
- Published
- 2016
7. Angiotensin receptor blockers are associated with lower mortality than ACE inhibitors in predialytic stage 5 chronic kidney disease: A nationwide study of therapy with renin-angiotensin system blockade
- Author
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Shuo Ming Ou, Der Cherng Tarng, Chi Yu Yang, Wu Chang Yang, Chih Cheng Hsu, Szu Yuan Li, Yu Te Wu, Jia Sin Liu, Chih Ching Lin, and Min Juei Tsai
- Subjects
medicine.medical_treatment ,lcsh:Medicine ,Angiotensin-Converting Enzyme Inhibitors ,030204 cardiovascular system & hematology ,ACE inhibitor therapy ,Pathology and Laboratory Medicine ,urologic and male genital diseases ,Biochemistry ,Geographical Locations ,Renin-Angiotensin System ,chemistry.chemical_compound ,Endocrinology ,0302 clinical medicine ,Chronic Kidney Disease ,Medicine and Health Sciences ,030212 general & internal medicine ,lcsh:Science ,Aged, 80 and over ,Multidisciplinary ,Proteinuria ,biology ,Pharmaceutics ,Hazard ratio ,Cardiovascular therapy ,Middle Aged ,Nephrology ,Creatinine ,Drug therapy ,medicine.symptom ,Research Article ,Adult ,medicine.medical_specialty ,Asia ,Endocrine Disorders ,Taiwan ,Urology ,Angiotensin Receptor Antagonists ,03 medical and health sciences ,Signs and Symptoms ,Diagnostic Medicine ,Diabetes mellitus ,Medical Dialysis ,Diabetes Mellitus ,medicine ,Humans ,Renal Insufficiency, Chronic ,Dialysis ,Aged ,Retrospective Studies ,business.industry ,lcsh:R ,Biology and Life Sciences ,Angiotensin-converting enzyme ,medicine.disease ,Blockade ,chemistry ,Metabolic Disorders ,People and Places ,biology.protein ,lcsh:Q ,business ,Biomarkers ,Kidney disease - Abstract
Dual renin angiotensin system (RAS) blockade using angiotensin-receptor blockers (ARBs) in combination with angiotensin converting enzyme inhibitors (ACEIs) is reported to improve proteinuria in both diabetic and non-diabetic patients. However, its renoprotective effect and safety remain uncertain in patients with advanced chronic kidney disease (CKD). From January 1, 2000 through June 30, 2009, we enrolled 14,117 pre-dialytic stage 5 CKD patients with serum creatinine >6mg/dL and hematocrit
- Published
- 2017
8. Diagnostic Accuracy of Urine Protein/Creatinine Ratio Is Influenced by Urine Concentration
- Author
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Chia Jen Shih, Chih Ching Lin, Wu Chang Yang, Wen Sheng Liu, An Hang Yang, Fu An Chen, Chih Yu Yang, Shuo Ming Ou, and Chun Fan Chen
- Subjects
Adult ,Male ,medicine.medical_specialty ,Urinalysis ,Urology ,lcsh:Medicine ,Urine ,Kidney ,Excretion ,chemistry.chemical_compound ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Renal Insufficiency, Chronic ,lcsh:Science ,Specific Gravity ,Aged ,Creatinine ,Multidisciplinary ,Proteinuria ,medicine.diagnostic_test ,Receiver operating characteristic ,Urine specific gravity ,lcsh:R ,Kidney metabolism ,Middle Aged ,Endocrinology ,chemistry ,Linear Models ,lcsh:Q ,Female ,medicine.symptom ,Research Article - Abstract
Background The usage of urine protein/creatinine ratio to estimate daily urine protein excretion is prevalent, but relatively little attention has been paid to the influence of urine concentration and its impact on test accuracy. We took advantage of 24-hour urine collection to examine both urine protein/creatinine ratio (UPCR) and daily urine protein excretion, with the latter as the reference standard. Specific gravity from a concomitant urinalysis of the same urine sample was used to indicate the urine concentration. Methods During 2010 to 2014, there were 540 adequately collected 24h urine samples with protein concentration, creatinine concentration, total volume, and a concomitant urinalysis of the same sample. Variables associated with an accurate UPCR estimation were determined by multivariate linear regression analysis. Receiver operating characteristic (ROC) curves were generated to determine the discriminant cut-off values of urine creatinine concentration for predicting an accurate UPCR estimation in either dilute or concentrated urine samples. Results Our findings indicated that for dilute urine, as indicated by a low urine specific gravity, UPCR is more likely to overestimate the actual daily urine protein excretion. On the contrary, UPCR of concentrated urine is more likely to result in an underestimation. By ROC curve analysis, the best cut-off value of urine creatinine concentration for predicting overestimation by UPCR of dilute urine (specific gravity ≦ 1.005) was ≦ 38.8 mg/dL, whereas the best cut-off values of urine creatinine for predicting underestimation by UPCR of thick urine were ≧ 63.6 mg/dL (specific gravity ≧ 1.015), ≧ 62.1 mg/dL (specific gravity ≧ 1.020), ≧ 61.5 mg/dL (specific gravity ≧ 1.025), respectively. We also compared distribution patterns of urine creatinine concentration of 24h urine cohort with a concurrent spot urine cohort and found that the underestimation might be more profound in single voided samples. Conclusions The UPCR in samples with low or high specific gravity is more likely to overestimate or underestimate actual daily urine protein amount, respectively, especially in a dilute urine sample with its creatinine below 38.8 mg/dL or a concentrated sample with its creatinine above 61.5 mg/dL. In particular, UPCR results should be interpreted with caution in cases that involve dilute urine samples because its overestimation may lead to an erroneous diagnosis of proteinuric renal disease or an incorrect staging of chronic kidney disease.
- Published
- 2015
9. The Effect of Cold Temperature on Increased Exacerbation of Chronic Obstructive Pulmonary Disease: A Nationwide Study
- Author
-
Shuo Ming Ou, Ching Min Tseng, Diahn-Warng Perng, Tzeng Ji Chen, Yi Han Hsiao, Yung Tai Chen, Shuu Jiun Wang, Szu Yuan Li, and Albert C. Yang
- Subjects
Male ,Environmental Impacts ,Atmospheric Science ,Acute exacerbation of chronic obstructive pulmonary disease ,Pulmonology ,Chronic Obstructive Pulmonary Diseases ,Exacerbation ,Epidemiology ,Cross-sectional study ,lcsh:Medicine ,Pulmonary Disease, Chronic Obstructive ,Registries ,lcsh:Science ,Aged, 80 and over ,Climatology ,COPD ,Multidisciplinary ,Ecology ,Agriculture ,Middle Aged ,Cold Temperature ,Air temperature ,Medicine ,Female ,Information Technology ,Research Article ,medicine.medical_specialty ,Ecological Metrics ,Climate Change ,Taiwan ,Pulmonary disease ,Environmental and Occupational Lung Diseases ,Environmental Epidemiology ,Databases ,Agricultural Production ,Internal medicine ,medicine ,Humans ,Biology ,Aged ,Retrospective Studies ,business.industry ,lcsh:R ,Retrospective cohort study ,medicine.disease ,respiratory tract diseases ,Cross-Sectional Studies ,Copd exacerbation ,Computer Science ,Earth Sciences ,Physical therapy ,lcsh:Q ,business - Abstract
BACKGROUND: Seasonal variations in the acute exacerbation of chronic obstructive pulmonary disease (COPD) have been reported. However, the influence of air temperature and other meteorological factors on COPD exacerbation remains unclear. METHODS: National Health Insurance registry data from January 1, 1999 to December 1, 2009 and meteorological variables from the Taiwan Central Weather Bureau for the same period were analyzed. A case-crossover study design was used to investigate the association between COPD exacerbation and meteorological variables. RESULTS: A total of 16,254 cases who suffered from COPD exacerbation were enrolled. We found that a 1°C decrease in air temperature was associated with a 0.8% increase in the exacerbation rate on event-days (95% confidence interval (CI), 1.015-1.138, p = 0.015). With a 5°C decrease in mean temperature, the cold temperature (28-day average temperature) had a long-term effect on the exacerbation of COPD (odds ratio (OR), 1.106, 95% CI 1.063-1.152, p
- Published
- 2013
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