8 results on '"Shan Shan Guo"'
Search Results
2. Is Hemoglobin Level in Patients with Nasopharyngeal Carcinoma Still a Significant Prognostic Factor in the Era of Intensity-Modulated Radiotherapy Technology?
- Author
-
Shan-Shan Guo, Lin-Quan Tang, Qiu-Yan Chen, Lu Zhang, Li-Ting Liu, Pei-Yu Huang, Ka-Jia Cao, Ling Guo, Hao-Yuan Mo, Xiang Guo, Ming-Huang Hong, Mu-Sheng Zeng, Chao-Nan Qian, and Hai-Qiang Mai
- Subjects
Medicine ,Science - Abstract
BACKGROUND:Hemoglobin (Hb) levels are regarded as an important determinant of outcome in a number of cancers treated with radiotherapy. However, for patients treated with intensity modulated radiotherapy (IMRT), information regarding the prognostic value of hemoglobin level is scarce. PATIENTS AND METHODS:A total of 650 patients with nasopharyngeal carcinoma (NPC), enrolled between May, 2005, and November, 2012, were included in this study. The prognostic significance of hemoglobin level (anemia or no-anemia) at three different time points was investigated, including before treatment, during treatment and at the last week of treatment. Univariate and multivariate analyses were conducted using the log-rank test and the Cox proportional hazards model, respectively. RESULTS:The 5-year OS (overall survival) rate of patients who were anemia and no-anemia before treatment were 89.1%, and 80.7% (P = 0.01), respectively. The 5-year DMFS (distant metastasis-free survival) rate of patients who were anemia and no-anemia before treatment were 88.9%, and 78.2% (P = 0.01), respectively. The 5-year OS rate of patients who were anemia and no-anemia during treatment were 91.7% and 83.3% (P = 0.004). According to multivariate analysis, the pre-treatment Hb level predicted a decreased DMFS (P = 0.007, HR = 2.555, 95% CI1.294-5.046). Besides, the mid-treatment Hb level predicted a decreased OS (P = 0.013, HR = 2.333, 95% CI1.199-4.541). CONCLUSIONS:Hemoglobin level is a useful prognostic factor in NPC patients receiving IMRT. It is important to control the level of hemoglobin both before and during chemoradiotherapy.
- Published
- 2015
- Full Text
- View/download PDF
3. Elevated high-sensitivity C-reactive protein levels predict decreased survival for nasopharyngeal carcinoma patients in the intensity-modulated radiotherapy era.
- Author
-
Lin Quan Tang, Dong Peng Hu, Qiu Yan Chen, Lu Zhang, Xiao Ping Lai, Yun He, Yun-Xiu-Xiu Xu, Shi-Hua Wen, Yu-Tuan Peng, Wen-Hui Chen, Shan-Shan Guo, Li-Ting Liu, Chao-Nan Qian, Xiang Guo, Mu-Sheng Zeng, and Hai-Qiang Mai
- Subjects
Medicine ,Science - Abstract
PURPOSE:This study aimed to clarify the prognostic utility of high-sensitivity C-reactive protein (hs-CRP) in nasopharyngeal carcinoma (NPC) patients in the Intensity-Modulated Radiotherapy (IMRT) era. PATIENTS AND METHODS:In this observational study, 1,589 non-metastatic NPC patients treated with IMRT were recruited. Blood samples were collected before treatment for examination of hs-CRP levels. We evaluated the association of pretreatment hs-CRP levels with overall survival rate (OS), progression free survival rate (PFS), locoregional relapse free survival rate (LRFS) and distant metastasis free survival rate (DMFS). RESULTS:Baseline hs-CRP levels were correlated with sex, clinical stage, body mass index, smoking status, and EBV DNA level. Multivariate analysis showed that hs-CRP had significant association with OS (HR:1.723; 95%CI:1.238-2.398; p = 0.001), PFS (HR:1.621; 95%CI:1.273-2.064; p
- Published
- 2015
- Full Text
- View/download PDF
4. Deciphering the mechanism of β-aminobutyric acid-induced resistance in wheat to the grain aphid, Sitobion avenae.
- Author
-
He-He Cao, Meng Zhang, Hui Zhao, Yi Zhang, Xing-Xing Wang, Shan-Shan Guo, Zhan-Feng Zhang, and Tong-Xian Liu
- Subjects
Medicine ,Science - Abstract
The non-protein amino acid β-aminobutyric acid (BABA) can induce plant resistance to a broad spectrum of biotic and abiotic stresses. However, BABA-induced plant resistance to insects is less well-studied, especially its underlying mechanism. In this research, we applied BABA to wheat seedlings and tested its effects on Sitobion avenae (F.). When applied as a soil drench, BABA significantly reduced weights of S. avenae, whereas foliar spray and seed treatment had no such effects. BABA-mediated suppression of S. avenae growth was dose dependent and lasted at least for 7 days. The aminobutyric acid concentration in phloem sap of BABA-treated plants was higher and increased with BABA concentrations applied. Moreover, after 10 days of treatment, the aminobutyric acid content in BABA-treated plants was still higher than that in control treatment. Sitobion avenae could not discriminate artificial diet containing BABA from standard diet, indicating that BABA itself is not a deterrent to this aphid. Also S. avenae did not show preference for control plants or BABA-treated plants. Consistent with choice test results, S. avenae had similar feeding activities on control and BABA-treated plants, suggesting that BABA did not induce antifeedants in wheat seedlings. In addition, aminobutyric acid concentration in S. avenae feeding on BABA-treated plants was significantly higher than those feeding on control plants. Sitobion avenae growth rate was reduced on the artificial diet containing BABA, indicating that BABA had direct toxic effects on this aphid species. These results suggest that BABA application reduced S. avenae performance on wheat seedlings and the mechanism is possibly due to direct toxicity of high BABA contents in plant phloem.
- Published
- 2014
- Full Text
- View/download PDF
5. Deciphering the mechanism of β-aminobutyric acid-induced resistance in wheat to the grain aphid, Sitobion avenae
- Author
-
Meng Zhang, He-He Cao, Shan-Shan Guo, Tong-Xian Liu, Yi Zhang, Hui Zhao, Xing-Xing Wang, and Zhan-Feng Zhang
- Subjects
Biochemistry ,chemistry.chemical_compound ,Sitobion avenae ,Amino Acids ,Triticum ,Abiotic component ,Aphid ,Multidisciplinary ,Ecology ,Aminobutyrates ,food and beverages ,Agriculture ,Chemistry ,Organic Acids ,Toxicity ,Wheat ,Physical Sciences ,Metallurgy ,Grain Structure ,Medicine ,Research Article ,Science ,Materials Science ,Crops ,Biology ,Phloem ,Aminobutyric acid ,Integrated Control ,Botany ,Animals ,Peroxidase ,Chemical Ecology ,fungi ,Body Weight ,Ecology and Environmental Sciences ,Organic Chemistry ,Chemical Compounds ,Biology and Life Sciences ,Proteins ,Feeding Behavior ,biology.organism_classification ,chemistry ,Seedling ,Seedlings ,Seed treatment ,Aphids ,Pest Control ,Zoology ,Entomology ,Acids ,Cereal Crops - Abstract
The non-protein amino acid β-aminobutyric acid (BABA) can induce plant resistance to a broad spectrum of biotic and abiotic stresses. However, BABA-induced plant resistance to insects is less well-studied, especially its underlying mechanism. In this research, we applied BABA to wheat seedlings and tested its effects on Sitobion avenae (F.). When applied as a soil drench, BABA significantly reduced weights of S. avenae, whereas foliar spray and seed treatment had no such effects. BABA-mediated suppression of S. avenae growth was dose dependent and lasted at least for 7 days. The aminobutyric acid concentration in phloem sap of BABA-treated plants was higher and increased with BABA concentrations applied. Moreover, after 10 days of treatment, the aminobutyric acid content in BABA-treated plants was still higher than that in control treatment. Sitobion avenae could not discriminate artificial diet containing BABA from standard diet, indicating that BABA itself is not a deterrent to this aphid. Also S. avenae did not show preference for control plants or BABA-treated plants. Consistent with choice test results, S. avenae had similar feeding activities on control and BABA-treated plants, suggesting that BABA did not induce antifeedants in wheat seedlings. In addition, aminobutyric acid concentration in S. avenae feeding on BABA-treated plants was significantly higher than those feeding on control plants. Sitobion avenae growth rate was reduced on the artificial diet containing BABA, indicating that BABA had direct toxic effects on this aphid species. These results suggest that BABA application reduced S. avenae performance on wheat seedlings and the mechanism is possibly due to direct toxicity of high BABA contents in plant phloem.
- Published
- 2013
6. Is Hemoglobin Level in Patients with Nasopharyngeal Carcinoma Still a Significant Prognostic Factor in the Era of Intensity-Modulated Radiotherapy Technology?
- Author
-
Qiu-Yan Chen, Lu Zhang, Hai-Qiang Mai, Pei Yu Huang, Lin-Quan Tang, Xiang Guo, Ming-Huang Hong, Ka-Jia Cao, Mu Sheng Zeng, Ling Guo, Shan-Shan Guo, Chao-Nan Qian, Hao-Yuan Mo, and Li-Ting Liu
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Anemia ,Nasopharyngeal neoplasm ,lcsh:Medicine ,Gastroenterology ,Hemoglobins ,Young Adult ,Internal medicine ,Carcinoma ,medicine ,Humans ,lcsh:Science ,Survival rate ,Aged ,Neoplasm Staging ,Retrospective Studies ,Nasopharyngeal Carcinoma ,Multidisciplinary ,business.industry ,Proportional hazards model ,lcsh:R ,Nasopharyngeal Neoplasms ,Middle Aged ,Prognosis ,medicine.disease ,Surgery ,Survival Rate ,Nasopharyngeal carcinoma ,lcsh:Q ,Female ,Radiotherapy, Intensity-Modulated ,Hemoglobin ,business ,Chemoradiotherapy ,Research Article - Abstract
Background Hemoglobin (Hb) levels are regarded as an important determinant of outcome in a number of cancers treated with radiotherapy. However, for patients treated with intensity modulated radiotherapy (IMRT), information regarding the prognostic value of hemoglobin level is scarce. Patients and Methods A total of 650 patients with nasopharyngeal carcinoma (NPC), enrolled between May, 2005, and November, 2012, were included in this study. The prognostic significance of hemoglobin level (anemia or no-anemia) at three different time points was investigated, including before treatment, during treatment and at the last week of treatment. Univariate and multivariate analyses were conducted using the log–rank test and the Cox proportional hazards model, respectively. Results The 5-year OS (overall survival) rate of patients who were anemia and no-anemia before treatment were 89.1%, and 80.7% (P = 0.01), respectively. The 5-year DMFS (distant metastasis-free survival) rate of patients who were anemia and no-anemia before treatment were 88.9%, and 78.2% (P = 0.01), respectively. The 5-year OS rate of patients who were anemia and no-anemia during treatment were 91.7% and 83.3% (P = 0.004). According to multivariate analysis, the pre-treatment Hb level predicted a decreased DMFS (P = 0.007, HR = 2.555, 95% CI1.294–5.046). Besides, the mid-treatment Hb level predicted a decreased OS (P = 0.013, HR = 2.333, 95% CI1.199–4.541). Conclusions Hemoglobin level is a useful prognostic factor in NPC patients receiving IMRT. It is important to control the level of hemoglobin both before and during chemoradiotherapy.
- Published
- 2015
7. Elevated High-Sensitivity C-Reactive Protein Levels Predict Decreased Survival for Nasopharyngeal Carcinoma Patients in the Intensity-Modulated Radiotherapy Era
- Author
-
Hai Qiang Mai, Xiao Ping Lai, Lin Quan Tang, Mu Sheng Zeng, Wen Hui Chen, Lu Zhang, Xiang Guo, Yun Xiu Xiu Xu, Yun He, Shi Hua Wen, Chao Nan Qian, Qiu Yan Chen, Yu Tuan Peng, Dong Peng Hu, Li Ting Liu, and Shan Shan Guo
- Subjects
Adult ,Male ,medicine.medical_specialty ,Nasopharyngeal neoplasm ,lcsh:Medicine ,Kaplan-Meier Estimate ,Gastroenterology ,Disease-Free Survival ,Risk Factors ,Diabetes mellitus ,Internal medicine ,Blood plasma ,medicine ,Humans ,Progression-free survival ,lcsh:Science ,Survival rate ,Aged ,Neoplasm Staging ,Nasopharyngeal Carcinoma ,Multidisciplinary ,biology ,business.industry ,Carcinoma ,lcsh:R ,C-reactive protein ,Nasopharyngeal Neoplasms ,Middle Aged ,Prognosis ,medicine.disease ,C-Reactive Protein ,Nasopharyngeal carcinoma ,Immunology ,biology.protein ,Female ,lcsh:Q ,Radiotherapy, Intensity-Modulated ,Cisplatin ,business ,Body mass index ,Research Article - Abstract
Purpose This study aimed to clarify the prognostic utility of high-sensitivity C-reactive protein (hs-CRP) in nasopharyngeal carcinoma (NPC) patients in the Intensity-Modulated Radiotherapy (IMRT) era. Patients and Methods In this observational study, 1,589 non-metastatic NPC patients treated with IMRT were recruited. Blood samples were collected before treatment for examination of hs-CRP levels. We evaluated the association of pretreatment hs-CRP levels with overall survival rate (OS), progression free survival rate (PFS), locoregional relapse free survival rate (LRFS) and distant metastasis free survival rate (DMFS). Results Baseline hs-CRP levels were correlated with sex, clinical stage, body mass index, smoking status, and EBV DNA level. Multivariate analysis showed that hs-CRP had significant association with OS (HR:1.723; 95%CI:1.238–2.398; p = 0.001), PFS (HR:1.621; 95%CI:1.273–2.064; p
- Published
- 2015
8. Different Prognostic Values of Plasma Epstein-Barr Virus DNA and Maximal Standardized Uptake Value of 18F-FDG PET/CT for Nasopharyngeal Carcinoma Patients with Recurrence
- Author
-
Lin Quan Tang, Mu Sheng Zeng, Hao Yuan Mo, Dong Hua Luo, Hai Qiang Mai, Chao Nan Qian, Shan Shan Guo, Pei Jing Li, Dong Mei Mai, Li Ting Liu, Ting Shen, Qiu Yan Chen, and Xiang Guo
- Subjects
Adult ,Male ,Epstein-Barr Virus Infections ,Herpesvirus 4, Human ,medicine.medical_specialty ,Pathology ,Adolescent ,medicine.medical_treatment ,Nasopharyngeal neoplasm ,lcsh:Medicine ,Standardized uptake value ,Gastroenterology ,Metastasis ,Fluorodeoxyglucose F18 ,Internal medicine ,Carcinoma ,medicine ,Humans ,lcsh:Science ,Child ,Survival analysis ,Aged ,Neoplasm Staging ,Nasopharyngeal Carcinoma ,Multidisciplinary ,business.industry ,lcsh:R ,Nasopharyngeal Neoplasms ,Middle Aged ,Prognosis ,medicine.disease ,Radiation therapy ,Nasopharyngeal carcinoma ,Positron-Emission Tomography ,DNA, Viral ,Biomarker (medicine) ,lcsh:Q ,Female ,Neoplasm Recurrence, Local ,Tomography, X-Ray Computed ,business ,Research Article - Abstract
Purpose To evaluate and compare the prognostic value of Epstein-Barr virus (EBV) DNA and maximal standard uptake values (SUVmax ) of 18F-fluoro-2-deoxy-D-glucose positron emission tomography (18F-FDG-PET) in subgroups of nasopharyngeal carcinoma (NPC) patients with locoregional or distant recurrence. Patients and Methods A total of 194 patients with recurrent NPC (locoregional recurrence: 107, distant recurrence: 87) were enrolled. Patients took evidence of recurrence performed with 18F-FDG-PET and an EBV DNA test before salvage treatment. Clinical parameters, the status of EBV DNA and the value of SUVmax were used for survival analysis using the Kaplan-Meier method and the Cox proportional hazards regression model. Results In the subgroup of patients with locoregional recurrence, patients with SUVmax
- Published
- 2015
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.