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Your search keyword '"Schalkwijk, Casper G."' showing total 14 results
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14 results on '"Schalkwijk, Casper G."'

2. Endothelial dysfunction and low-grade inflammation in the transition to renal replacement therapy

Author

Gennip, April C. E. van, primary, Broers, Natascha J. H., additional, Meulen, Karlien J. ter, additional, Canaud, Bernard, additional, Christiaans, Maarten H. L., additional, Cornelis, Tom, additional, Gelens, Mariëlle A. C. J., additional, Hermans, Marc M. H., additional, Konings, Constantijn J. A. M., additional, Net, Jeroen B. van der, additional, Sande, Frank M. van der, additional, Schalkwijk, Casper G., additional, Stifft, Frank, additional, Wirtz, Joris J. J. M., additional, Kooman, Jeroen P., additional, and Martens, Remy J. H., additional

Published
2019
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3. Relations of advanced glycation endproducts and dicarbonyls with endothelial dysfunction and low-grade inflammation in individuals with end-stage renal disease in the transition to renal replacement therapy: A cross-sectional observational study

Author

Martens, Remy J. H., primary, Broers, Natascha J. H., additional, Canaud, Bernard, additional, Christiaans, Maarten H. L., additional, Cornelis, Tom, additional, Gauly, Adelheid, additional, Hermans, Marc M. H., additional, Konings, Constantijn J. A. M., additional, van der Sande, Frank M., additional, Scheijen, Jean L. J. M., additional, Stifft, Frank, additional, Wirtz, Joris J. J. M., additional, Kooman, Jeroen P., additional, and Schalkwijk, Casper G., additional

Published
2019
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7. The Course of Skin and Serum Biomarkers of Advanced Glycation Endproducts and Its Association with Oxidative Stress, Inflammation, Disease Severity, and Mortality during ICU Admission in Critically Ill Patients: Results from a Prospective Pilot Study

Author

Meertens, John H., primary, Nienhuis, Hans L., additional, Lefrandt, Joop D., additional, Schalkwijk, Casper G., additional, Nyyssönen, Kristiina, additional, Ligtenberg, Jack J. M., additional, Smit, Andries J., additional, Zijlstra, Jan G., additional, and Mulder, D. J., additional

Published
2016
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8. A Control Systems Approach to Quantify Wall Shear Stress Normalization by Flow-Mediated Dilation in the Brachial Artery

Author

van Bussel, Frank C. G., primary, van Bussel, Bas C. T., additional, Hoeks, Arnold P. G., additional, Op 't Roodt, Jos, additional, Henry, Ronald M. A., additional, Ferreira, Isabel, additional, Vanmolkot, Floris H. M., additional, Schalkwijk, Casper G., additional, Stehouwer, Coen D. A., additional, and Reesink, Koen D., additional

Published
2015
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10. Multiple Inflammatory Biomarker Detection in a Prospective Cohort Study: A Cross-Validation between Well-Established Single-Biomarker Techniques and an Electrochemiluminescense-Based Multi-Array Platform

Author

van Bussel, Bas C. T., primary, Ferreira, Isabel, additional, van de Waarenburg, Marjo P. H., additional, van Greevenbroek, Marleen M. J., additional, van der Kallen, Carla J. H., additional, Henry, Ronald M. A., additional, Feskens, Edith J. M., additional, Stehouwer, Coen D. A., additional, and Schalkwijk, Casper G., additional

Published
2013
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11. Irreversible Renal Damage after Transient Renin-Angiotensin System Stimulation: Involvement of an AT1-Receptor Mediated Immune Response

Author

Heijnen, Bart F. J., primary, Nelissen, Jelly, additional, van Essen, Helma, additional, Fazzi, Gregorio E., additional, Cohen Tervaert, Jan W., additional, Peutz-Kootstra, Carine J., additional, Mullins, John J., additional, Schalkwijk, Casper G., additional, Janssen, Ben J. A., additional, and Struijker-Boudier, Harry AJ., additional

Published
2013
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12. Diastolic Dysfunction of Aging Is Independent of Myocardial Structure but Associated with Plasma Advanced Glycation End-Product Levels

Author

Campbell, Duncan J., primary, Somaratne, Jithendra B., additional, Jenkins, Alicia J., additional, Prior, David L., additional, Yii, Michael, additional, Kenny, James F., additional, Newcomb, Andrew E., additional, Schalkwijk, Casper G., additional, Black, Mary Jane, additional, and Kelly, Darren J., additional

Published
2012
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13. Effect of Benfotiamine on Advanced Glycation Endproducts and Markers of Endothelial Dysfunction and Inflammation in Diabetic Nephropathy

Author

Alkhalaf, Alaa, primary, Kleefstra, Nanne, additional, Groenier, Klaas H., additional, Bilo, Henk J. G., additional, Gans, Reinold O. B., additional, Heeringa, Peter, additional, Scheijen, Jean L., additional, Schalkwijk, Casper G., additional, Navis, Gerjan J., additional, and Bakker, Stephan J. L., additional

Published
2012
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14. Irreversible Renal Damage after Transient Renin-Angiotensin System Stimulation: Involvement of an AT1-Receptor Mediated Immune Response.

Author

Heijnen, Bart F. J., Nelissen, Jelly, van Essen, Helma, Fazzi, Gregorio E., Cohen Tervaert, Jan W., Peutz-Kootstra, Carine J., Mullins, John J., Schalkwijk, Casper G., Janssen, Ben J. A., and Struijker-Boudier, Harry AJ.

Subjects
KIDNEY diseases, RENIN-angiotensin system, ANGIOTENSIN receptors, IMMUNE response, BLOOD pressure, KIDNEY function tests, LABORATORY rats
Abstract

Transient activation of the renin-angiotensin system (RAS) induces irreversible renal damage causing sustained elevation in blood pressure (BP) in Cyp1a1-Ren2 transgenic rats. In our current study we hypothesized that activation of the AT1-receptor (AT1R) leads to a T-cell response causing irreversible impairment of renal function and hypertension. Cyp1a1-Ren2 rats harbor a construct for activation of the RAS by indole-3-carbinol (I3C). Rats were fed a I3C diet between 4–8 weeks of age to induce hypertension. Next, I3C was withdrawn and rats were followed-up for another 12 weeks. Additional groups received losartan (20 mg/kg/day) or hydralazine (100 mg/kg/day) treatment between 4–8 weeks. Rats were placed for 24h in metabolic cages before determining BP at week 8, 12 and 20. At these ages, subsets of animals were sacrificed and the presence of kidney T-cell subpopulations was investigated by immunohistochemistry and molecular marker analysis. The development of sustained hypertension was completely prevented by losartan, whereas hydralazine only caused a partial decrease in BP. Markers of renal damage: KIM-1 and osteopontin were highly expressed in urine and kidney samples of I3C-treated rats, even until 20 weeks of age. Additionally, renal expression of regulatory-T cells (Tregs) was highly increased in I3C-treated rats, whereas the expression of T-helper 1 (Th1) cells demonstrated a strong decrease. Losartan prevented these effects completely, whereas hydralazine was unable to affect these changes. In young Cyp1a1-Ren2 rats AT1R activation leads to induction of an immune response, causing a shift from Th1-cells to Tregs, contributing to the development of irreversible renal damage and hypertension. [ABSTRACT FROM AUTHOR]

Published
2013
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