1. Hepatitis B virus reactivation after radiotherapy for hepatocellular carcinoma and efficacy of antiviral treatment: A multicenter study
- Author
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Dae Hee Choi, Moon Young Kim, Sae Hwan Lee, Soung Won Jeong, Sang Hyeon Choi, Baek Gyu Jun, Minjong Lee, Ki Tae Suk, Hong Soo Kim, Tae Suk Kim, Young Don Kim, Seong Hee Kang, Young Seok Kim, Soon Koo Baik, Sang Gyune Kim, Dong Joon Kim, Gab Jin Cheon, and Jae Young Jang
- Subjects
Male ,HBsAg ,medicine.medical_treatment ,Cancer Treatment ,lcsh:Medicine ,medicine.disease_cause ,Gastroenterology ,Mathematical and Statistical Techniques ,0302 clinical medicine ,Risk Factors ,Public and Occupational Health ,lcsh:Science ,Pathology and laboratory medicine ,Multidisciplinary ,Liver Diseases ,Liver Neoplasms ,Middle Aged ,Medical microbiology ,Hepatitis B ,Vaccination and Immunization ,Oncology ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,Viruses ,Physical Sciences ,Female ,030211 gastroenterology & hepatology ,Pathogens ,Statistics (Mathematics) ,Research Article ,Hepatic Resection ,Clinical Oncology ,Hepatitis B virus ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Immunology ,Radiation Therapy ,Surgical and Invasive Medical Procedures ,Gastroenterology and Hepatology ,Research and Analysis Methods ,Antiviral Agents ,Microbiology ,Carcinomas ,Digestive System Procedures ,03 medical and health sciences ,Antiviral Therapy ,Virology ,Internal medicine ,Gastrointestinal Tumors ,medicine ,Carcinoma ,Humans ,Clinical significance ,Chemoembolization, Therapeutic ,Statistical Methods ,Aged ,Medicine and health sciences ,Hepatitis ,Biology and life sciences ,Surgical Resection ,business.industry ,lcsh:R ,Viral pathogens ,Organisms ,Cancers and Neoplasms ,Hepatocellular Carcinoma ,medicine.disease ,Hepatitis viruses ,Viral Replication ,digestive system diseases ,Microbial pathogens ,Clinical trial ,Radiation therapy ,Multivariate Analysis ,Virus Activation ,lcsh:Q ,Preventive Medicine ,Clinical Medicine ,business ,Mathematics - Abstract
Convincing data that support routine use of preventive therapy against hepatitis B virus (HBV) reactivation in radiotherapy (RT) for hepatocellular carcinoma (HCC) are lacking. The aim of this study was to investigate the incidence, clinical significance, and risk factors of HBV reactivation after RT. Medical records of 133 HBsAg (+) HCC patients who received radiotherapy from March 2009 to February 2016 were reviewed. Patients were divided into two groups: 1) non-antiviral group, those who did not receive antiviral therapy before RT (n = 27); and antiviral group (those who underwent antiviral therapy before RT) (n = 106). Factors related to HBV reactivation in HCC patients were evaluated. 17 (12.7%) of 133 patients developed HBV reactivation after RT. Patients in the antiviral group had significantly lower rates of HBV reactivation than those in the non-antiviral group (7.5% vs. 33.3%, p
- Published
- 2018
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