1. Rosemary supplementation (Rosmarinus oficinallis L.) attenuates cardiac remodeling after myocardial infarction in rats
- Author
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Paula S. Azevedo, Marcos F. Minicucci, Katashi Okoshi, Leonardo A. M. Zornoff, Ana Angélica Henrique Fernandes, Priscila P. Santos, Bruna Paola Murino Rafacho, Sergio A. R. Paiva, Andréa Gonçalves, Xiang-Dong Wang, Fernanda Chiuso-Minicucci, Universidade Estadual Paulista (Unesp), and Tufts University
- Subjects
Male ,0301 basic medicine ,Antioxidant ,Physiology ,medicine.medical_treatment ,Myocardial Infarction ,lcsh:Medicine ,Infarction ,Blood Pressure ,030204 cardiovascular system & hematology ,Pathology and Laboratory Medicine ,medicine.disease_cause ,Biochemistry ,Antioxidants ,Rosmarinus ,Muscle hypertrophy ,0302 clinical medicine ,Fibrosis ,Medicine and Health Sciences ,Myocardial infarction ,lcsh:Science ,Multidisciplinary ,Ventricular Remodeling ,biology ,Heart ,Enzymes ,Dismutases ,Physiological Parameters ,Cardiology ,Anatomy ,Research Article ,medicine.medical_specialty ,NF-E2-Related Factor 2 ,Systole ,03 medical and health sciences ,Signs and Symptoms ,Diagnostic Medicine ,Internal medicine ,medicine ,Animals ,Rats, Wistar ,Superoxide Dismutase ,Plant Extracts ,business.industry ,lcsh:R ,Body Weight ,Biology and Life Sciences ,Proteins ,Cell Biology ,Feeding Behavior ,medicine.disease ,biology.organism_classification ,Survival Analysis ,Oxidative Stress ,Metabolism ,030104 developmental biology ,Endocrinology ,Blood pressure ,Dietary Supplements ,Cardiovascular Anatomy ,Enzymology ,lcsh:Q ,Energy Metabolism ,Physiological Processes ,business ,Oxidative stress - Abstract
Made available in DSpace on 2018-12-11T17:11:36Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-05-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Background: Myocardial infarction (MI) is one of the leading causes of morbidity and mortality worldwide. Dietary intervention on adverse cardiac remodeling after MI has significant clinical relevance. Rosemary leaves are a natural product with antioxidant/anti-inflammatory properties, but its effect on morphology and ventricular function after MI is unknown. Methods and results: To determine the effect of the dietary supplementation of rosemary leaves on cardiac remodeling after MI, male Wistar rats were divided into 6 groups after sham procedure or experimental induced MI: 1) Sham group fed standard chow (SR0, n = 23); 2) Sham group fed standard chow supplemented with 0.02% rosemary (R002) (SR002, n = 23); 3) Sham group fed standard chow supplemented with 0.2% rosemary (R02) (SR02, n = 22); 4) group submitted to MI and fed standard chow (IR0, n = 13); 5) group submitted to MI and fed standard chow supplemented with R002 (IR002, n = 8); and 6) group submitted to MI and fed standard chow supplemented with R02 (IR02, n = 9). After 3 months of the treatment, systolic pressure evaluation, echocardiography and euthanasia were performed. Left ventricular samples were evaluated for: fibrosis, cytokine levels, apoptosis, energy metabolism enzymes, and oxidative stress. Rosemary dietary supplementation attenuated cardiac remodeling by improving energy metabolism and decreasing oxidative stress. Rosemary supplementation of 0.02% improved diastolic function and reduced hypertrophy after MI. Regarding rosemary dose, 0.02% and 0.2% for rats are equivalent to 11 mg and 110 mg for humans, respectively. Conclusion: Our findings support further investigations of the rosemary use as adjuvant therapy in adverse cardiac remodeling. Internal Medicine Department Botucatu Medical School UNESP Department of Biochemistry Botucatu Biosciences Institute UNESP Department of Microbiology and Immunology Botucatu Biosciences Institute UNESP Nutrition and Cancer Biology Laboratory Jean Mayer USDA Human Nutrition Research Center on Aging Tufts University Internal Medicine Department Botucatu Medical School UNESP Department of Biochemistry Botucatu Biosciences Institute UNESP Department of Microbiology and Immunology Botucatu Biosciences Institute UNESP FAPESP: 2011/08956-0 FAPESP: 2011/15059-5
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- 2017