1. Gene network analysis in a pediatric cohort identifies novel lung function genes.
- Author
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Bruce A Ong, Jin Li, Joseph M McDonough, Zhi Wei, Cecilia Kim, Rosetta Chiavacci, Frank Mentch, Jason B Caboot, Jonathan Spergel, Julian L Allen, Patrick M A Sleiman, and Hakon Hakonarson
- Subjects
Medicine ,Science - Abstract
Lung function is a heritable trait and serves as an important clinical predictor of morbidity and mortality for pulmonary conditions in adults, however, despite its importance, no studies have focused on uncovering pediatric-specific loci influencing lung function. To identify novel genetic determinants of pediatric lung function, we conducted a genome-wide association study (GWAS) of four pulmonary function traits, including FVC, FEV1, FEV1/FVC and FEF25-75% in 1556 children. Further, we carried out gene network analyses for each trait including all SNPs with a P-value of
- Published
- 2013
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