Search

Your search keyword '"Ron, Bose"' showing total 2 results
Start Over Author "Ron, Bose" Journal plos one
2 results on '"Ron, Bose"'

1. Prioritizing Potentially Druggable Mutations with dGene: An Annotation Tool for Cancer Genome Sequencing Data.

Author

Runjun D Kumar, Li-Wei Chang, Matthew J Ellis, and Ron Bose

Subjects
Medicine, Science
Abstract

A major goal of cancer genome sequencing is to identify mutations or other somatic alterations that can be targeted by selective and specific drugs. dGene is an annotation tool designed to rapidly identify genes belonging to one of ten druggable classes that are frequently targeted in cancer drug development. These classes were comprehensively populated by combining and manually curating data from multiple specialized and general databases. dGene was used by The Cancer Genome Atlas squamous cell lung cancer project, and here we further demonstrate its utility using recently released breast cancer genome sequencing data. dGene is designed to be usable by any cancer researcher without the need for support from a bioinformatics specialist. A full description of dGene and options for its implementation are provided here.

Published
2013
Full Text
View/download PDF

2. Prioritizing Potentially Druggable Mutations with dGene: An Annotation Tool for Cancer Genome Sequencing Data

Author

Li-Wei Chang, Ron Bose, Matthew J. Ellis, and Runjun D. Kumar

Subjects
Cancer genome sequencing, Druggability, Cancer Treatment, lcsh:Medicine, Biochemistry, 0302 clinical medicine, Neoplasms, Drug Discovery, Breast Tumors, Genome Sequencing, lcsh:Science, Genetics, 0303 health sciences, Multidisciplinary, Cancer Risk Factors, Obstetrics and Gynecology, Genomics, 3. Good health, Oncology, 030220 oncology & carcinogenesis, Medicine, Research Article, Biotechnology, Genetic Causes of Cancer, Antineoplastic Agents, Biology, Squamous cell lung cancer, Polymorphism, Single Nucleotide, DNA sequencing, 03 medical and health sciences, Annotation, Breast cancer, Genomic Medicine, Genome Analysis Tools, Breast Cancer, medicine, Cancer Genetics, Humans, Gene, 030304 developmental biology, Genome, Human, lcsh:R, Computational Biology, Cancers and Neoplasms, Molecular Sequence Annotation, medicine.disease, Cancer Genome Project, Mutation, lcsh:Q
Abstract

A major goal of cancer genome sequencing is to identify mutations or other somatic alterations that can be targeted by selective and specific drugs. dGene is an annotation tool designed to rapidly identify genes belonging to one of ten druggable classes that are frequently targeted in cancer drug development. These classes were comprehensively populated by combining and manually curating data from multiple specialized and general databases. dGene was used by The Cancer Genome Atlas squamous cell lung cancer project, and here we further demonstrate its utility using recently released breast cancer genome sequencing data. dGene is designed to be usable by any cancer researcher without the need for support from a bioinformatics specialist. A full description of dGene and options for its implementation are provided here.

Published
2013

Catalog

Books, media, physical & digital resources
See catalog results