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The semicircular canal (SC) system of the inner ear detects head angular accelerations and is essential for navigation and spatial awareness in vertebrates. Because the bony labyrinth encloses the membranous labyrinth SCs, it can be used as a proxy for animal behavior. The bony labyrinth of dicynodonts, a clade of herbivorous non-mammalian synapsids, has only been described in a handful of individuals and remains particularly obscure. Here we describe the bony labyrinth anatomy of three Endothiodon cf. bathystoma specimens from Mozambique based on digital reconstructions from propagation phase-contrast synchrotron micro-computed tomography. We compare these findings with the bony labyrinth anatomy of their close relative Niassodon. The bony labyrinths of Endothiodon and Niassodon are relatively similar and show only differences in the shape of the horizontal SCs and the orientation of the vertical SCs. When compared to extant mammals, Endothiodon and Niassodon have highly eccentric SCs. In addition, the Endothiodon SCs are nearly orthogonal. An eccentric and orthogonal SC morphology is consistent with a specialization in rapid head movements, which are typical of foraging or feeding behaviors. Furthermore, we estimate the body mass of these Endothiodon specimens at ~116 to 182 kg, based on the average SC radii calculated using a linear regression model optimized by the Amemiya Prediction Criterion. Our findings provide novel insights into the paleobiology of Endothiodon which are consistent with the peculiar feeding mechanism among dicynodonts presumed from their multiple postcanine toothrows.

Microvilli (stereocilia) projecting from the apex of hair cells in the inner ear are actively motile structures that feed energy into the vibration of the inner ear and enhance sensitivity to sound. The biophysical mechanism underlying the hair bundle motor is unknown. In this study, we examined a membrane flexoelectric origin for active movements in stereocilia and conclude that it is likely to be an important contributor to mechanical power output by hair bundles. We formulated a realistic biophysical model of stereocilia incorporating stereocilia dimensions, the known flexoelectric coefficient of lipid membranes, mechanical compliance, and fluid drag. Electrical power enters the stereocilia through displacement sensitive ion channels and, due to the small diameter of stereocilia, is converted to useful mechanical power output by flexoelectricity. This motor augments molecular motors associated with the mechanosensitive apparatus itself that have been described previously. The model reveals stereocilia to be highly efficient and fast flexoelectric motors that capture the energy in the extracellular electro-chemical potential of the inner ear to generate mechanical power output. The power analysis provides an explanation for the correlation between stereocilia height and the tonotopic organization of hearing organs. Further, results suggest that flexoelectricity may be essential to the exquisite sensitivity and frequency selectivity of non-mammalian hearing organs at high auditory frequencies, and may contribute to the "cochlear amplifier" in mammals.