Search

Your search keyword '"Radbruch, Alexander"' showing total 11 results
Start Over Author "Radbruch, Alexander" Journal plos one
11 results on '"Radbruch, Alexander"'

2. Capillary Transit Time Heterogeneity Is Associated with Modified Rankin Scale Score at Discharge in Patients with Bilateral High Grade Internal Carotid Artery Stenosis

Author

Mundiyanapurath, Sibu, Ringleb, Peter Arthur, Diatschuk, Sascha, Hansen, Mikkel Bo, Mouridsen, Kim, Østergaard, Leif, Wick, Wolfgang, Bendszus, Martin, and Radbruch, Alexander

Subjects
Male, Cardiovascular Procedures, Cerebrovascular Diseases, Perfusion Imaging, lcsh:Medicine, Surgical and Invasive Medical Procedures, Pathology and Laboratory Medicine, Vascular Medicine, Carotid Endarterectomy, Signs and Symptoms, Diagnostic Medicine, Risk Factors, Medicine and Health Sciences, Image Processing, Computer-Assisted, Humans, Carotid Stenosis, lcsh:Science, Ischemic Stroke, Aged, Stenosis, lcsh:R, Biology and Life Sciences, Arteries, Middle Aged, Magnetic Resonance Imaging, Capillaries, Stroke, Carotid Arteries, Neurology, ROC Curve, Regional Blood Flow, Stent Implantation, Cardiovascular Anatomy, Blood Vessels, Female, lcsh:Q, Anatomy, Blood Flow Velocity, Carotid Artery, Internal, Research Article
Abstract

BACKGROUND AND PURPOSE: Perfusion weighted imaging (PWI) is inherently unreliable in patients with severe perfusion abnormalities. We compared the diagnostic accuracy of a novel index of microvascular flow-patterns, so-called capillary transit time heterogeneity (CTH) to that of the commonly used delay parameter Tmax in patients with bilateral high grade internal carotid artery stenosis (ICAS).METHODS: Consecutive patients with bilateral ICAS ≥ 70%NASCET who underwent PWI were retrospectively examined. Maps of CTH and Tmax were analyzed with a volumetric approach using several thresholds. Predictors of favorable outcome (modified Rankin scale at discharge 0-2) were identified using univariate and receiver operating characteristic (ROC) curve analysis.RESULTS: Eighteen patients were included. CTH ≥ 30s differentiated best between patients with favorable and unfavorable outcome when both hemispheres were taken into account (sensitivity 83%, specificity 73%, area under the curve [AUC] 0.833 [confidence interval (CI) 0.635; 1.000]; p = 0.027). The best discrimination using Tmax was achieved with a threshold of ≥ 4s (sensitivity 83%, specificity 64%, AUC 0.803 [CI 0.585;1.000]; p = 0.044). The highest AUC was found for left sided volume with CTH ≥ 15s (sensitivity 83%, specificity 91%, AUC 0.924 [CI 0.791;1.000]; p = 0.005).CONCLUSION: The study suggests that CTH is superior to Tmax in discriminating ICAS patients with favorable from non-favorable outcome. This finding may reflect the simultaneous involvement of large vessels and microvessels in ICAS and underscore the need to diagnose and manage both aspects of the disease.

Published
2016

4. Tumor Infiltration in Enhancing and Non-Enhancing Parts of Glioblastoma: A Correlation with Histopathology

Author

Eidel, Oliver, primary, Burth, Sina, additional, Neumann, Jan-Oliver, additional, Kieslich, Pascal J., additional, Sahm, Felix, additional, Jungk, Christine, additional, Kickingereder, Philipp, additional, Bickelhaupt, Sebastian, additional, Mundiyanapurath, Sibu, additional, Bäumer, Philipp, additional, Wick, Wolfgang, additional, Schlemmer, Heinz-Peter, additional, Kiening, Karl, additional, Unterberg, Andreas, additional, Bendszus, Martin, additional, and Radbruch, Alexander, additional

Published
2017
Full Text
View/download PDF

5. Automatic Analysis of Cellularity in Glioblastoma and Correlation with ADC Using Trajectory Analysis and Automatic Nuclei Counting

Author

Eidel, Oliver, primary, Neumann, Jan-Oliver, additional, Burth, Sina, additional, Kieslich, Pascal J., additional, Jungk, Christine, additional, Sahm, Felix, additional, Kickingereder, Philipp, additional, Kiening, Karl, additional, Unterberg, Andreas, additional, Wick, Wolfgang, additional, Schlemmer, Heinz-Peter, additional, Bendszus, Martin, additional, and Radbruch, Alexander, additional

Published
2016
Full Text
View/download PDF

6. Asymmetry of Deep Medullary Veins on Susceptibility Weighted MRI in Patients with Acute MCA Stroke Is Associated with Poor Outcome

Author

Mucke, Johanna, primary, Möhlenbruch, Markus, additional, Kickingereder, Philipp, additional, Kieslich, Pascal J., additional, Bäumer, Philipp, additional, Gumbinger, Christoph, additional, Purrucker, Jan, additional, Mundiyanapurath, Sibu, additional, Schlemmer, Heinz-Peter, additional, Bendszus, Martin, additional, and Radbruch, Alexander, additional

Published
2015
Full Text
View/download PDF

7. Nuclear Overhauser Enhancement Imaging of Glioblastoma at 7 Tesla: Region Specific Correlation with Apparent Diffusion Coefficient and Histology

Author

Paech, Daniel, primary, Burth, Sina, additional, Windschuh, Johannes, additional, Meissner, Jan-Eric, additional, Zaiss, Moritz, additional, Eidel, Oliver, additional, Kickingereder, Philipp, additional, Nowosielski, Martha, additional, Wiestler, Benedikt, additional, Sahm, Felix, additional, Floca, Ralf Omar, additional, Neumann, Jan-Oliver, additional, Wick, Wolfgang, additional, Heiland, Sabine, additional, Bendszus, Martin, additional, Schlemmer, Heinz-Peter, additional, Ladd, Mark Edward, additional, Bachert, Peter, additional, and Radbruch, Alexander, additional

Published
2015
Full Text
View/download PDF

8. Quantification of Tumor Vessels in Glioblastoma Patients Using Time-of-Flight Angiography at 7 Tesla: A Feasibility Study

Author

Radbruch, Alexander, primary, Eidel, Oliver, additional, Wiestler, Benedikt, additional, Paech, Daniel, additional, Burth, Sina, additional, Kickingereder, Philipp, additional, Nowosielski, Martha, additional, Bäumer, Philipp, additional, Wick, Wolfgang, additional, Schlemmer, Heinz-Peter, additional, Bendszus, Martin, additional, Ladd, Mark, additional, Nagel, Armin Michael, additional, and Heiland, Sabine, additional

Published
2014
Full Text
View/download PDF

9. Nuclear Overhauser Enhancement Mediated Chemical Exchange Saturation Transfer Imaging at 7 Tesla in Glioblastoma Patients

Author

Paech, Daniel, primary, Zaiss, Moritz, additional, Meissner, Jan-Eric, additional, Windschuh, Johannes, additional, Wiestler, Benedikt, additional, Bachert, Peter, additional, Neumann, Jan Oliver, additional, Kickingereder, Philipp, additional, Schlemmer, Heinz-Peter, additional, Wick, Wolfgang, additional, Nagel, Armin Michael, additional, Heiland, Sabine, additional, Ladd, Mark Edward, additional, Bendszus, Martin, additional, and Radbruch, Alexander, additional

Published
2014
Full Text
View/download PDF

10. Comparison of Susceptibility Weighted Imaging and TOF-Angiography for the Detection of Thrombi in Acute Stroke

Author

Radbruch, Alexander, primary, Mucke, Johanna, additional, Schweser, Ferdinand, additional, Deistung, Andreas, additional, Ringleb, Peter Alexander, additional, Ziener, Christian Herbert, additional, Roethke, Matthias, additional, Schlemmer, Heinz-Peter, additional, Heiland, Sabine, additional, Reichenbach, Jürgen R., additional, Bendszus, Martin, additional, and Rohde, Stefan, additional

Published
2013
Full Text
View/download PDF

11. Quantitative Susceptibility Mapping Differentiates between Blood Depositions and Calcifications in Patients with Glioblastoma

Author

Deistung, Andreas, primary, Schweser, Ferdinand, additional, Wiestler, Benedikt, additional, Abello, Mario, additional, Roethke, Matthias, additional, Sahm, Felix, additional, Wick, Wolfgang, additional, Nagel, Armin Michael, additional, Heiland, Sabine, additional, Schlemmer, Heinz-Peter, additional, Bendszus, Martin, additional, Reichenbach, Jürgen Rainer, additional, and Radbruch, Alexander, additional

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results