1. Neural Correlates of the Severity of Cocaine, Heroin, Alcohol, MDMA and Cannabis Use in Polysubstance Abusers: A Resting-PET Brain Metabolism Study
- Author
-
Manuel Gómez-Río, Laura Moreno-López, Miguel Pérez-García, Emmanuel Stamatakis, Antonio Rodríguez-Fernández, María José Fernández-Serrano, Antonio Verdejo-García, Stamatakis, Emmanuel [0000-0001-6955-9601], Apollo - University of Cambridge Repository, [Moreno-López,L, Pérez-García,M, Verdejo-García,A] Department of Personality, Evaluation and Psychological Treatment, University of Granada, Granada, Spain. [Stamatakis,EA] Division of Anaesthesia, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom. [Fernández-Serrano,MJ] Department of Psychology, University of Jaén, Jaén, Spain. [Gómez-Río,M, Rodríguez-Fernández,A] Service of Nuclear Medicine of the Hospital Virgen de las Nieves of Granada, Granada. [Pérez-García,M] Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, University of Granada, Granada, Spain. [Pérez-García,M, Verdejo-García,A] Institute of Neurosciences Federico Olóriz, University of Granada, Granada, Spain, and This study has been supported with funds from the SEJ2006-08278 project from the Spanish Ministry of Education and Science, the P07-HUM-03089 project from the Council of Science and Innovation. Laura Moreno-López is supported by the FPU grant (AP2007-03583) from the Spanish Ministry of Science and Innovation. Antonio Verdejo-García was supported by a MCINN Jose Castillejo grant in the Department of Experimental Psychology, University of Cambridge. Emmanuel A. Stamatakis is supported by the Stephen Erskine Fellowship from Queens’ College, Cambridge.
- Subjects
Conducta Adictiva ,Male ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Neuroimaging::Functional Neuroimaging [Medical Subject Headings] ,Diseases::Substance-Related Disorders::Cocaine-Related Disorders [Medical Subject Headings] ,PET imaging ,lcsh:Medicine ,Social and Behavioral Sciences ,Trastornos Relacionados con Cocaína ,Heroin ,Behavioral Neuroscience ,Diseases::Substance-Related Disorders::Opioid-Related Disorders::Heroin Dependence [Medical Subject Headings] ,Cocaine ,Neurobiology of Disease and Regeneration ,Psychology ,lcsh:Science ,Diseases::Substance-Related Disorders::Marijuana Abuse [Medical Subject Headings] ,Vías Nerviosas ,media_common ,Temporal cortex ,Drug Dependence ,Multidisciplinary ,Alcoholismo ,biology ,Brain ,MDMA ,Neuroimagen Funcional ,FOS: Sociology ,Humanos ,medicine.anatomical_structure ,Encéfalo ,Polysubstance dependence ,Behavioral Pharmacology ,Drug users ,Tomografía de Emisión de Positrones ,Medicine ,Female ,Radiology ,medicine.drug ,Research Article ,Adult ,medicine.medical_specialty ,Positron emission tomography ,Drugs and Devices ,Substance-Related Disorders ,media_common.quotation_subject ,Cognitive Neuroscience ,N-Methyl-3,4-methylenedioxyamphetamine ,Rest ,Dependencia de Heroína ,Neuroimaging ,Trastornos relacionados con el uso de sustancias ,Diseases::Substance-Related Disorders [Medical Subject Headings] ,Premotor cortex ,Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Impulsive Behavior::Compulsive Behavior::Behavior, Addictive [Medical Subject Headings] ,Neuropsychology ,Recreational Drug Use ,mental disorders ,medicine ,Humans ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Image Interpretation, Computer-Assisted::Tomography, Emission-Computed::Positron-Emission Tomography [Medical Subject Headings] ,Abuso de Marihuana ,Psychiatry ,Biology ,Cannabis ,Demography ,Chemicals and Drugs::Organic Chemicals::Amines::Ethylamines::Phenethylamines::Amphetamines [Medical Subject Headings] ,Drug metabolism ,Chemicals and Drugs::Organic Chemicals::Amines::Ethylamines::Phenethylamines::Amphetamines::N-Methyl-3,4-methylenedioxyamphetamine [Medical Subject Headings] ,Ethanol ,business.industry ,Illicit Drugs ,Addiction ,lcsh:R ,Anatomy::Nervous System::Central Nervous System::Brain [Medical Subject Headings] ,biology.organism_classification ,Dorsolateral prefrontal cortex ,Pet ,Alcohols ,Positron-Emission Tomography ,Nuclear medicine ,N-Metil-3,4-metilenodioxianfetamina ,Anatomy::Nervous System::Neural Pathways [Medical Subject Headings] ,lcsh:Q ,Diseases::Substance-Related Disorders::Alcohol-Related Disorders::Alcoholism [Medical Subject Headings] ,business ,Neuroscience - Abstract
Introduction Functional imaging studies of addiction following protracted abstinence have not been systematically conducted to look at the associations between severity of use of different drugs and brain dysfunction. Findings from such studies may be relevant to implement specific interventions for treatment. The aim of this study was to examine the association between resting-state regional brain metabolism (measured with 18F-fluorodeoxyglucose Positron Emission Tomography (FDG-PET) and the severity of use of cocaine, heroin, alcohol, MDMA and cannabis in a sample of polysubstance users with prolonged abstinence from all drugs used., Methods Our sample consisted of 49 polysubstance users enrolled in residential treatment. We conducted correlation analyses between estimates of use of cocaine, heroin, alcohol, MDMA and cannabis and brain metabolism (BM) (using Statistical Parametric Mapping voxel-based (VB) whole-brain analyses). In all correlation analyses conducted for each of the drugs we controlled for the co-abuse of the other drugs used., Results The analysis showed significant negative correlations between severity of heroin, alcohol, MDMA and cannabis use and BM in the dorsolateral prefrontal cortex (DLPFC) and temporal cortex. Alcohol use was further associated with lower metabolism in frontal premotor cortex and putamen, and stimulants use with parietal cortex., Conclusions Duration of use of different drugs negatively correlated with overlapping regions in the DLPFC, whereas severity of cocaine, heroin and alcohol use selectively impact parietal, temporal, and frontal-premotor/basal ganglia regions respectively. The knowledge of these associations could be useful in the clinical practice since different brain alterations have been associated with different patterns of execution that may affect the rehabilitation of these patients., This study has been supported with funds from the SEJ2006-08278 project from the Spanish Ministry of Education and Science, the P07-HUM-03089 project from the Council of Science and Innovation. Laura Moreno-López is supported by the FPU grant (AP2007-03583) from the Spanish Ministry of Science and Innovation.
- Published
- 2012