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21 results on '"Neubauer, Stefan"'

2. Does self-reported pregnancy loss identify women at risk of an adverse cardiovascular phenotype in later life? Insights from UK Biobank

Author

Elmahi, Einas, primary, Sanghvi, Mihir M., additional, Jones, Alexander, additional, Aye, Christina Y. L., additional, Lewandowski, Adam J., additional, Aung, Nay, additional, Cooper, Jackie A., additional, Paiva, José Miguel, additional, Lukaschuk, Elena, additional, Piechnik, Stefan K., additional, Neubauer, Stefan, additional, Petersen, Steffen E., additional, and Leeson, Paul, additional

Published
2019
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3. Non-invasive assessment of portal hypertension by multi-parametric magnetic resonance imaging of the spleen: A proof of concept study

Author

Levick, Christina, primary, Phillips-Hughes, Jane, additional, Collier, Jane, additional, Banerjee, Rajarshi, additional, Cobbold, Jeremy F., additional, Wang, Lai Mun, additional, Piechnik, Stefan K., additional, Robson, Matthew D., additional, Neubauer, Stefan, additional, Barnes, Eleanor, additional, and Pavlides, Michael, additional

Published
2019
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4. Repeatability and reproducibility of multiparametric magnetic resonance imaging of the liver

Author

Bachtiar, Velicia, primary, Kelly, Matthew D., additional, Wilman, Henry R., additional, Jacobs, Jaco, additional, Newbould, Rexford, additional, Kelly, Catherine J., additional, Gyngell, Michael L., additional, Groves, Katherine E., additional, McKay, Andy, additional, Herlihy, Amy H., additional, Fernandes, Carolina C., additional, Halberstadt, Mark, additional, Maguire, Marion, additional, Jayaratne, Naomi, additional, Linden, Sophia, additional, Neubauer, Stefan, additional, and Banerjee, Rajarshi, additional

Published
2019
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5. Automated localization and quality control of the aorta in cine CMR can significantly accelerate processing of the UK Biobank population data

Author

Biasiolli, Luca, primary, Hann, Evan, additional, Lukaschuk, Elena, additional, Carapella, Valentina, additional, Paiva, Jose M., additional, Aung, Nay, additional, Rayner, Jennifer J., additional, Werys, Konrad, additional, Fung, Kenneth, additional, Puchta, Henrike, additional, Sanghvi, Mihir M., additional, Moon, Niall O., additional, Thomson, Ross J., additional, Thomas, Katharine E., additional, Robson, Matthew D., additional, Grau, Vicente, additional, Petersen, Steffen E., additional, Neubauer, Stefan, additional, and Piechnik, Stefan K., additional

Published
2019
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7. Using a whole-body 31P birdcage transmit coil and 16-element receive array for human cardiac metabolic imaging at 7T

Author

Valkovič, Ladislav, Dragonu, Iulius, Almujayyaz, Salam, Batzakis, Alex, Young, Liam AJ, Purvis, Lucian AB, Clarke, William T, Wichmann, Tobias, Lanz, Titus, Neubauer, Stefan, Robson, Matthew D, Klomp, Dennis WJ, Rodgers, Christopher T, Valkovič, Ladislav [0000-0003-2567-3642], and Apollo - University of Cambridge Repository

Subjects
Magnetic Resonance Spectroscopy, Imaging Techniques, lcsh:Medicine, Signal-To-Noise Ratio, Research and Analysis Methods, Biochemistry, Diagnostic Radiology, Diagnostic Medicine, Medicine and Health Sciences, Metabolites, Humans, Signal to Noise Ratio, lcsh:Science, Musculoskeletal System, Cardiac Muscles, Radiology and Imaging, Muscles, lcsh:R, Biology and Life Sciences, Phosphorus Isotopes, Heart, Magnetic Resonance Imaging, Health Care, Metabolism, Skeletal Muscles, Signal Processing, Cardiovascular Anatomy, Engineering and Technology, lcsh:Q, Anatomy, Research Article
Abstract

PURPOSE: Cardiac phosphorus magnetic resonance spectroscopy (31P-MRS) provides unique insight into the mechanisms of heart failure. Yet, clinical applications have been hindered by the restricted sensitivity of the surface radiofrequency-coils normally used. These permit the analysis of spectra only from the interventricular septum, or large volumes of myocardium, which may not be meaningful in focal disease. Löring et al. recently presented a prototype whole-body (52 cm diameter) transmit/receive birdcage coil for 31P at 7T. We now present a new, easily-removable, whole-body 31P transmit radiofrequency-coil built into a patient-bed extension combined with a 16-element receive array for cardiac 31P-MRS. MATERIALS AND METHODS: A fully-removable (55 cm diameter) birdcage transmit coil was combined with a 16-element receive array on a Magnetom 7T scanner (Siemens, Germany). Electro-magnetic field simulations and phantom tests of the setup were performed. In vivo maps of B1+, metabolite signals, and saturation-band efficiency were acquired across the torsos of eight volunteers. RESULTS: The combined (volume-transmit, local receive array) setup increased signal-to-noise ratio 2.6-fold 10 cm below the array (depth of the interventricular septum) compared to using the birdcage coil in transceiver mode. The simulated coefficient of variation for B1+ of the whole-body coil across the heart was 46.7% (surface coil 129.0%); and the in vivo measured value was 38.4%. Metabolite images of 2,3-diphosphoglycerate clearly resolved the ventricular blood pools, and muscle tissue was visible in phosphocreatine (PCr) maps. Amplitude-modulated saturation bands achieved 71±4% suppression of phosphocreatine PCr in chest-wall muscles. Subjects reported they were comfortable. CONCLUSION: This easy-to-assemble, volume-transmit, local receive array coil combination significantly improves the homogeneity and field-of-view for metabolic imaging of the human heart at 7T.

Published
2017

8. Utility and variability of three non-invasive liver fibrosis imaging modalities to evaluate efficacy of GR-MD-02 in subjects with NASH and bridging fibrosis during a phase-2 randomized clinical trial

Author

Harrison, Stephen A., primary, Dennis, Andrea, additional, Fiore, Martine M., additional, Kelly, Matt D., additional, Kelly, Catherine J., additional, Paredes, Angelo H., additional, Whitehead, Jennifer M., additional, Neubauer, Stefan, additional, Traber, Peter G., additional, and Banerjee, Rajarshi, additional

Published
2018
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9. Variation in lung function and alterations in cardiac structure and function—Analysis of the UK Biobank cardiovascular magnetic resonance imaging substudy

Author

Thomson, Ross J., primary, Aung, Nay, additional, Sanghvi, Mihir M., additional, Paiva, Jose Miguel, additional, Lee, Aaron M., additional, Zemrak, Filip, additional, Fung, Kenneth, additional, Pfeffer, Paul E., additional, Mackay, Alexander J., additional, McKeever, Tricia M., additional, Lukaschuk, Elena, additional, Carapella, Valentina, additional, Kim, Young Jin, additional, Bolton, Charlotte E., additional, Piechnik, Stefan K., additional, Neubauer, Stefan, additional, and Petersen, Steffen E., additional

Published
2018
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10. Prospective association between handgrip strength and cardiac structure and function in UK adults

Author

Beyer, Sebastian E., primary, Sanghvi, Mihir M., additional, Aung, Nay, additional, Hosking, Alice, additional, Cooper, Jackie A., additional, Paiva, José Miguel, additional, Lee, Aaron M., additional, Fung, Kenneth, additional, Lukaschuk, Elena, additional, Carapella, Valentina, additional, Mittleman, Murray A., additional, Brage, Soren, additional, Piechnik, Stefan K., additional, Neubauer, Stefan, additional, and Petersen, Steffen E., additional

Published
2018
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11. The impact of menopausal hormone therapy (MHT) on cardiac structure and function: Insights from the UK Biobank imaging enhancement study

Author

Sanghvi, Mihir M., primary, Aung, Nay, additional, Cooper, Jackie A., additional, Paiva, José Miguel, additional, Lee, Aaron M., additional, Zemrak, Filip, additional, Fung, Kenneth, additional, Thomson, Ross J., additional, Lukaschuk, Elena, additional, Carapella, Valentina, additional, Kim, Young Jin, additional, Harvey, Nicholas C., additional, Piechnik, Stefan K., additional, Neubauer, Stefan, additional, and Petersen, Steffen E., additional

Published
2018
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12. The impact of cardiovascular risk factors on cardiac structure and function: Insights from the UK Biobank imaging enhancement study

Author

Petersen, Steffen E., primary, Sanghvi, Mihir M., additional, Aung, Nay, additional, Cooper, Jackie A., additional, Paiva, José Miguel, additional, Zemrak, Filip, additional, Fung, Kenneth, additional, Lukaschuk, Elena, additional, Lee, Aaron M., additional, Carapella, Valentina, additional, Kim, Young Jin, additional, Piechnik, Stefan K., additional, and Neubauer, Stefan, additional

Published
2017
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14. Correction: Characterisation of liver fat in the UK Biobank cohort

Author

Wilman, Henry R., primary, Kelly, Matt, additional, Garratt, Steve, additional, Matthews, Paul M., additional, Milanesi, Matteo, additional, Herlihy, Amy, additional, Gyngell, Michael, additional, Neubauer, Stefan, additional, Bell, Jimmy D., additional, Banerjee, Rajarshi, additional, and Thomas, E. Louise, additional

Published
2017
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15. Characterisation of liver fat in the UK Biobank cohort

Author

Wilman, Henry R., primary, Kelly, Matt, additional, Garratt, Steve, additional, Matthews, Paul M., additional, Milanesi, Matteo, additional, Herlihy, Amy, additional, Gyngell, Micheal, additional, Neubauer, Stefan, additional, Bell, Jimmy D., additional, Banerjee, Rajarshi, additional, and Thomas, E. Louise, additional

Published
2017
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17. Using a whole-body 31P birdcage transmit coil and 16-element receive array for human cardiac metabolic imaging at 7T.

Author

Valkovič, Ladislav, Dragonu, Iulius, Almujayyaz, Salam, Batzakis, Alex, Young, Liam A. J., Purvis, Lucian A. B., Clarke, William T., Wichmann, Tobias, Lanz, Titus, Neubauer, Stefan, Robson, Matthew D., Klomp, Dennis W. J., and Rodgers, Christopher T.

Subjects
HEART failure, NUCLEAR magnetic resonance spectroscopy, CARDIAC imaging, RADIO frequency, METABOLITES, PHOSPHOCREATINE
Abstract

Purpose: Cardiac phosphorus magnetic resonance spectroscopy (31P-MRS) provides unique insight into the mechanisms of heart failure. Yet, clinical applications have been hindered by the restricted sensitivity of the surface radiofrequency-coils normally used. These permit the analysis of spectra only from the interventricular septum, or large volumes of myocardium, which may not be meaningful in focal disease. Löring et al. recently presented a prototype whole-body (52 cm diameter) transmit/receive birdcage coil for 31P at 7T. We now present a new, easily-removable, whole-body 31P transmit radiofrequency-coil built into a patient-bed extension combined with a 16-element receive array for cardiac 31P-MRS. Materials and methods: A fully-removable (55 cm diameter) birdcage transmit coil was combined with a 16-element receive array on a Magnetom 7T scanner (Siemens, Germany). Electro-magnetic field simulations and phantom tests of the setup were performed. In vivo maps of B1+, metabolite signals, and saturation-band efficiency were acquired across the torsos of eight volunteers. Results: The combined (volume-transmit, local receive array) setup increased signal-to-noise ratio 2.6-fold 10 cm below the array (depth of the interventricular septum) compared to using the birdcage coil in transceiver mode. The simulated coefficient of variation for B1+ of the whole-body coil across the heart was 46.7% (surface coil 129.0%); and the in vivo measured value was 38.4%. Metabolite images of 2,3-diphosphoglycerate clearly resolved the ventricular blood pools, and muscle tissue was visible in phosphocreatine (PCr) maps. Amplitude-modulated saturation bands achieved 71±4% suppression of phosphocreatine PCr in chest-wall muscles. Subjects reported they were comfortable. Conclusion: This easy-to-assemble, volume-transmit, local receive array coil combination significantly improves the homogeneity and field-of-view for metabolic imaging of the human heart at 7T. [ABSTRACT FROM AUTHOR]

Published
2017
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20. The Effect of High-Altitude on Human Skeletal Muscle Energetics: 31P-MRS Results from the Caudwell Xtreme Everest Expedition.

Author

Edwards, Lindsay M., Murray, Andrew J., Tyler, Damian J., Kemp, Graham J., Holloway, Cameron J., Robbins, Peter A., Neubauer, Stefan, Levett, Denny, Montgomery, Hugh E., Grocott, Mike P., and Clarke, Kieran

Subjects
INFLUENCE of altitude, HYPOXEMIA, MUSCLE diseases, MAGNETIC resonance imaging, PHYSIOLOGICAL effects of atmospheric pressure, MITOCHONDRIA, MORPHOLOGY, METABOLITES, MUSCULAR atrophy
Abstract

Many disease states are associated with regional or systemic hypoxia. The study of healthy individuals exposed to highaltitude hypoxia offers a way to explore hypoxic adaptation without the confounding effects of disease and therapeutic interventions. Using 31P magnetic resonance spectroscopy and imaging, we investigated skeletal muscle energetics and morphology after exposure to hypobaric hypoxia in seven altitude-naïve subjects (trekkers) and seven experienced climbers. The trekkers ascended to 5300 m while the climbers ascended above 7950 m. Before the study, climbers had better mitochondrial function (evidenced by shorter phosphocreatine recovery halftime) than trekkers: 1661 vs. 2262 s (mean 6 SE, p<0.01). Climbers had higher resting [Pi] than trekkers before the expedition and resting [Pi] was raised across both groups on their return (PRE: 2.6±0.2 vs. POST: 3.0±0.2 mM, p<0.05). There was significant muscle atrophy post-CXE (PRE: 4.7±0.2 vs. POST: 4.5±0.2 cm², p<0.05), yet exercising metabolites were unchanged. These results suggest that, in response to high altitude hypoxia, skeletal muscle function is maintained in humans, despite significant atrophy. [ABSTRACT FROM AUTHOR]

Published
2010
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21. The effect of high-altitude on human skeletal muscle energetics: P-MRS results from the Caudwell Xtreme Everest expedition.

Author

Edwards LM, Murray AJ, Tyler DJ, Kemp GJ, Holloway CJ, Robbins PA, Neubauer S, Levett D, Montgomery HE, Grocott MP, and Clarke K

Subjects
Adult, Exercise, Humans, Hydrogen-Ion Concentration, Kinetics, Magnetic Resonance Spectroscopy, Male, Middle Aged, Phosphocreatine metabolism, Young Adult, Altitude, Energy Metabolism physiology, Expeditions, Mountaineering physiology, Muscle, Skeletal physiology
Abstract

Many disease states are associated with regional or systemic hypoxia. The study of healthy individuals exposed to high-altitude hypoxia offers a way to explore hypoxic adaptation without the confounding effects of disease and therapeutic interventions. Using (31)P magnetic resonance spectroscopy and imaging, we investigated skeletal muscle energetics and morphology after exposure to hypobaric hypoxia in seven altitude-naïve subjects (trekkers) and seven experienced climbers. The trekkers ascended to 5300 m while the climbers ascended above 7950 m. Before the study, climbers had better mitochondrial function (evidenced by shorter phosphocreatine recovery halftime) than trekkers: 16+/-1 vs. 22+/-2 s (mean +/- SE, p<0.01). Climbers had higher resting [Pi] than trekkers before the expedition and resting [Pi] was raised across both groups on their return (PRE: 2.6+/-0.2 vs. POST: 3.0+/-0.2 mM, p<0.05). There was significant muscle atrophy post-CXE (PRE: 4.7+/-0.2 vs. POST: 4.5+/-0.2 cm(2), p<0.05), yet exercising metabolites were unchanged. These results suggest that, in response to high altitude hypoxia, skeletal muscle function is maintained in humans, despite significant atrophy.

Published
2010
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