11 results on '"Nae-Fang Miao"'
Search Results
2. Children's mobile-gaming preferences, online risks, and mental health.
- Author
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Chun-Yin Hou, Ru Rutherford, Hsi Chang, Fong-Ching Chang, Liu Shumei, Chiung-Hui Chiu, Ping-Hung Chen, Jeng-Tung Chiang, Nae-Fang Miao, Hung-Yi Chuang, and Chie-Chien Tseng
- Subjects
Medicine ,Science - Abstract
This study examined the relationships between children's mobile gaming preferences, online risks, and mental health. Data were obtained from a sample of 2,702 third and fourth grade students from 16 elementary schools in Taiwan and 9 schools in China. A self-administered questionnaire was used. The mental state of the children who participated in the study was assessed using the Strengths and Difficulties Questionnaire (SDQ), while mobile gaming addiction was assessed using the short form of the Internet Gaming Disorders Scale (IGDS9-SF). The results showed that about 54% of children played mobile games with others (multi-player), while 31% played mobile games alone, and 15% did not play mobile games. Multiple logistic regression results indicated that behaviors such as participating in multi-player games, playing violent games, a poor parent-child relationship, and living in a rural area were associated with a greater risk of mobile gaming addiction. Involvement in multi-player games, playing violent games, mobile gaming addiction, and exposure to mobile violence/pornography were associated with greater risks of cyber aggression/victimization. Multiple regression results showed that being a multi-player, playing violent games, mobile gaming addiction, exposure to violence/pornography, exposure to cyber aggression/victimization, and having a poor parent-child relationship were associated with emotional and behavioral problems. more...
- Published
- 2022
- Full Text
- View/download PDF
Catalog
3. Combinations of SERPINB5 gene polymorphisms and environmental factors are associated with oral cancer risks.
- Author
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Hsiu-Ting Tsai, Ming-Ju Hsieh, Chiao-Wen Lin, Shih-Chi Su, Nae-Fang Miao, Shun-Fa Yang, Hui-Chuan Huang, Fu-Chih Lai, and Yu-Fan Liu
- Subjects
Medicine ,Science - Abstract
BACKGROUND:We identified rs17071138 T/C, rs3744941 C/T, and rs8089104 T/C gene polymorphisms of SERPINB5 (mammary serine protease inhibitor) that are specific to patients with oral cancer susceptibility and their clinicopathological status. METHODOLOGY/PRINCIPAL FINDINGS:In total, 1342 participants, including 601 healthy controls and 741 patients with oral cancer, were recruited for this study. Allelic discrimination of rs17071138 T/C, rs3744941 C/T, and rs8089104 T/C of the SERPINB5 gene was assessed by a real-time PCR with a TaqMan assay. We found that individuals carrying the polymorphic rs17071138 and rs8089104 are more susceptible to oral cancer (OR, 1.57; 95% CI, 1.07~2.31 and OR, 1.58; 95% CI, 1.04~2.39, respectively). Among oral cancer-related risk factor exposures, the individuals carrying the polymorphic rs17071138 had 4.26- (95% CI: 1.65~11.01; p = 0.002), 2.34- (95% CI: 1.19~4.61; p = 0.01), and 2.34-fold (95% CI: 1.38~3.96; p = 0.001) higher risks of developing oral cancer. CONCLUSIONS:Heterozygous TC of the SERPINB5 rs17071138 polymorphism may be a factor that increases susceptibility to oral cancer. Interactions of gene-to-gene and gene-to-oral cancer-related environmental risk factors have a synergetic effect that can further enhance oral cancer development. more...
- Published
- 2017
- Full Text
- View/download PDF
4. Effects of Salivary Oxidative Markers on Edentulous Patients' Satisfaction with Prosthetic Denture Treatments: A Pilot Study.
- Author
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Chia-Huang Chang, Chang-Yu Lee, Sheng-Wei Feng, Nae-Fang Miao, Pei-Huan Lin, Che-Tong Lin, Shin-Han Tsai, and Yung-Kai Huang
- Subjects
Medicine ,Science - Abstract
OBJECTIVES:The purpose of this study was to assess relationships among periodontal conditions, salivary antioxidant levels, and patients' satisfaction with their prostheses. METHODS:This study was conducted at the Division of Prosthodontics, Department of Dentistry, Taipei Medical University Hospital. The periodontal condition of patients was based on an assessment of the plaque index (PI) and gingival index (GI). The pH value, flow rate, and buffer capacity of the saliva were estimated. The salivary total antioxidant status (TAS) and superoxide dismutase (SOD) level were also determined. Patients' satisfaction with prosthetic treatments was evaluated using the Chinese version of the short-form Oral Health Impact Profile (OHIP-14C). A multivariate regression model was used to determine whether patients' satisfaction with prosthetic treatment was affected by their oral health status. RESULTS:In total, 35 edentulous patients were recruited. In the Spearman correlation analysis, salivary pH (r = -0.36, p = 0.03) and the buffer ability (r = -0.48, p more...
- Published
- 2016
- Full Text
- View/download PDF
5. Impact of Maspin Polymorphism rs2289520 G/C and Its Interaction with Gene to Gene, Alcohol Consumption Increase Susceptibility to Oral Cancer Occurrence.
- Author
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Po-Yu Yang, Nae-Fang Miao, Chiao-Wen Lin, Ying-Erh Chou, Shun-Fa Yang, Hui-Chuan Huang, Hsiu-Ju Chang, and Hsiu-Ting Tsai
- Subjects
Medicine ,Science - Abstract
The purpose of this study was to identify gene polymorphisms of mammary serine protease inhibitor (Maspin) specific to patients with oral cancer susceptibility and clinicopathological status.Three single-nucleotide polymorphisms (SNPs) of the Maspin gene from 741 patients with oral cancer and 601 non-cancer controls were analyzed by real-time PCR. The participants with G/G homozygotes or with G/C heterozygotes of Maspin rs2289520 polymorphism had a 2.07-fold (p = 0.01) and a 2.01-fold (p = 0.02) risk of developing oral cancer compared to those with C/C homozygotes. Moreover, gene-gene interaction increased the risk of oral cancer susceptibility among subjects expose to oral cancer related risk factors, including areca, alcohol, and tobacco consumption.G allele of Maspin rs2289520 polymorphism may be a factor that increases the susceptibility to oral cancer. The interactions of gene to oral cancer-related environmental risk factors have a synergetic effect that can further enhance oral cancer development. more...
- Published
- 2016
- Full Text
- View/download PDF
6. Development and Psychometric Evaluation of the Chinese Feeding Difficulty Index (Ch-FDI) for People with Dementia.
- Author
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Megan F Liu, Nae-Fang Miao, I-Hui Chen, Yen-Kuang Lin, Mu-Hsing Ho, Beverly L Roberts, and Chia-Chi Chang
- Subjects
Medicine ,Science - Abstract
To develop and evaluate the psychometric properties of a Chinese Feeding Difficulty Index (Ch-FDI) which assesses feeding difficulties in people with dementia (PwD).Scale items were developed using literature review based on Model of Feeding Difficulty. Content validity was evaluated and items were modified by expert panel. Following translation and back-translation, the Ch-FDI was piloted on residents with dementia. The reliability was tested by inter-rater reliability and test-retest reliability. Internal reliability was established by calculating Cronbach's α coefficient. The concurrent validity was evaluated by correlating with similar scale, the Edinburgh Feeding Evaluation in Dementia (EdFED). The exploratory factor analysis (EFA) with varimax rotation and parallel analysis (PA) was performed to test construct validity.Participants were recruited from long-term care facilities in Taiwan. A total of 213 residents with dementia participated in this study during May, 2010 to February, 2011.Content validation, translation and psychometric testing were completed on the 19 items of the Ch-FDI. The translated scale was piloted on 213 residents with dementia of feeding difficulty who were recruited from eight long-term care facilities in Taiwan. The reliability was supported by the internal consistency of Cronbach's α of 0.68 and a test-retest coefficient of 0.85. The content validity, face validity, concurrent validity, and construct validity were used.The Ch-FDI is a newly developed scale with fair psychometric properties aimed to measure feeding difficulties among residents with dementia in long-term care facilities in Taiwan. Using this reliable and valid tool can help healthcare providers to assess feeding problems of PwD and provide feeding assistance in order to promote quality of care during mealtime in long-term care facilities. more...
- Published
- 2015
- Full Text
- View/download PDF
7. Children's mobile-gaming preferences, online risks, and mental health
- Author
-
Chun-Yin Hou, Ru Rutherford, Hsi Chang, Fong-Ching Chang, Liu Shumei, Chiung-Hui Chiu, Ping-Hung Chen, Jeng-Tung Chiang, Nae-Fang Miao, Hung-Yi Chuang, and Chie-Chien Tseng
- Subjects
Aggression ,Multidisciplinary ,Mental Health ,Video Games ,Humans ,Mobile Applications ,Cyberbullying - Abstract
This study examined the relationships between children’s mobile gaming preferences, online risks, and mental health. Data were obtained from a sample of 2,702 third and fourth grade students from 16 elementary schools in Taiwan and 9 schools in China. A self-administered questionnaire was used. The mental state of the children who participated in the study was assessed using the Strengths and Difficulties Questionnaire (SDQ), while mobile gaming addiction was assessed using the short form of the Internet Gaming Disorders Scale (IGDS9-SF). The results showed that about 54% of children played mobile games with others (multi-player), while 31% played mobile games alone, and 15% did not play mobile games. Multiple logistic regression results indicated that behaviors such as participating in multi-player games, playing violent games, a poor parent-child relationship, and living in a rural area were associated with a greater risk of mobile gaming addiction. Involvement in multi-player games, playing violent games, mobile gaming addiction, and exposure to mobile violence/pornography were associated with greater risks of cyber aggression/victimization. Multiple regression results showed that being a multi-player, playing violent games, mobile gaming addiction, exposure to violence/pornography, exposure to cyber aggression/victimization, and having a poor parent-child relationship were associated with emotional and behavioral problems. more...
- Published
- 2021
8. Combinations of SERPINB5 gene polymorphisms and environmental factors are associated with oral cancer risks
- Author
-
Yu-Fan Liu, Ming-Ju Hsieh, Nae Fang Miao, Shun-Fa Yang, Chiao Wen Lin, Hui Chuan Huang, Shih-Chi Su, Hsiu Ting Tsai, and Fu Chih Lai
- Subjects
Oncology ,Environmental Impacts ,Skin Neoplasms ,lcsh:Medicine ,Gene Expression ,Oral Mucosal Cancers ,Metastasis ,0302 clinical medicine ,Gene Frequency ,Risk Factors ,Basic Cancer Research ,Medicine and Health Sciences ,Gene–environment interaction ,lcsh:Science ,Skin Tumors ,Areca ,Mouth neoplasm ,Multidisciplinary ,Alcohol Consumption ,biology ,Cancer Risk Factors ,Smoking ,Cell Differentiation ,030220 oncology & carcinogenesis ,Mouth Neoplasms ,Research Article ,medicine.medical_specialty ,Alcohol Drinking ,Dermatology ,Polymorphism, Single Nucleotide ,03 medical and health sciences ,Internal medicine ,TaqMan ,medicine ,Genetics ,Humans ,Genetic Predisposition to Disease ,Allele ,Gene ,Allele frequency ,Alleles ,Serpins ,Nutrition ,Evolutionary Biology ,Population Biology ,lcsh:R ,Ecology and Environmental Sciences ,Case-control study ,Biology and Life Sciences ,Cancers and Neoplasms ,030206 dentistry ,biology.organism_classification ,Molecular biology ,Diet ,Case-Control Studies ,Genetic Polymorphism ,lcsh:Q ,Gene-Environment Interaction ,Population Genetics ,Developmental Biology - Abstract
Background We identified rs17071138 T/C, rs3744941 C/T, and rs8089104 T/C gene polymorphisms of SERPINB5 (mammary serine protease inhibitor) that are specific to patients with oral cancer susceptibility and their clinicopathological status. Methodology/principal findings In total, 1342 participants, including 601 healthy controls and 741 patients with oral cancer, were recruited for this study. Allelic discrimination of rs17071138 T/C, rs3744941 C/T, and rs8089104 T/C of the SERPINB5 gene was assessed by a real-time PCR with a TaqMan assay. We found that individuals carrying the polymorphic rs17071138 and rs8089104 are more susceptible to oral cancer (OR, 1.57; 95% CI, 1.07~2.31 and OR, 1.58; 95% CI, 1.04~2.39, respectively). Among oral cancer-related risk factor exposures, the individuals carrying the polymorphic rs17071138 had 4.26- (95% CI: 1.65~11.01; p = 0.002), 2.34- (95% CI: 1.19~4.61; p = 0.01), and 2.34-fold (95% CI: 1.38~3.96; p = 0.001) higher risks of developing oral cancer. Conclusions Heterozygous TC of the SERPINB5 rs17071138 polymorphism may be a factor that increases susceptibility to oral cancer. Interactions of gene-to-gene and gene-to-oral cancer-related environmental risk factors have a synergetic effect that can further enhance oral cancer development. more...
- Published
- 2016
9. Impact of Maspin Polymorphism rs2289520 G/C and Its Interaction with Gene to Gene, Alcohol Consumption Increase Susceptibility to Oral Cancer Occurrence
- Author
-
Ying Erh Chou, Shun-Fa Yang, Hui Chuan Huang, Hsiu Ju Chang, Nae Fang Miao, Hsiu Ting Tsai, Chiao Wen Lin, and Po Yu Yang
- Subjects
Male ,lcsh:Medicine ,Artificial Gene Amplification and Extension ,Apoptosis ,Polymerase Chain Reaction ,0302 clinical medicine ,Medicine and Health Sciences ,lcsh:Science ,Areca ,Multidisciplinary ,Alcohol Consumption ,biology ,Cell Death ,Cancer Risk Factors ,Middle Aged ,Oncology ,Cell Processes ,030220 oncology & carcinogenesis ,Physical Sciences ,Female ,Mouth Neoplasms ,Alcohol consumption ,Statistics (Mathematics) ,Research Article ,Alcohol Drinking ,Single-nucleotide polymorphism ,Genetic Predisposition ,Research and Analysis Methods ,Polymorphism, Single Nucleotide ,03 medical and health sciences ,Genetics ,Confidence Intervals ,Humans ,Genetic Predisposition to Disease ,Allele ,Molecular Biology Techniques ,Gene ,Molecular Biology ,Serpins ,Alleles ,Nutrition ,Serine protease ,Evolutionary Biology ,Population Biology ,lcsh:R ,Maspin ,Biology and Life Sciences ,Heterozygote advantage ,Epistasis, Genetic ,030206 dentistry ,Cell Biology ,biology.organism_classification ,Diet ,stomatognathic diseases ,Genetic Loci ,Case-Control Studies ,Genetics of Disease ,biology.protein ,Cancer research ,Genetic Polymorphism ,lcsh:Q ,Population Genetics ,Mathematics - Abstract
BACKGROUND The purpose of this study was to identify gene polymorphisms of mammary serine protease inhibitor (Maspin) specific to patients with oral cancer susceptibility and clinicopathological status. METHODOLOGY/PRINCIPAL FINDINGS Three single-nucleotide polymorphisms (SNPs) of the Maspin gene from 741 patients with oral cancer and 601 non-cancer controls were analyzed by real-time PCR. The participants with G/G homozygotes or with G/C heterozygotes of Maspin rs2289520 polymorphism had a 2.07-fold (p = 0.01) and a 2.01-fold (p = 0.02) risk of developing oral cancer compared to those with C/C homozygotes. Moreover, gene-gene interaction increased the risk of oral cancer susceptibility among subjects expose to oral cancer related risk factors, including areca, alcohol, and tobacco consumption. CONCLUSION G allele of Maspin rs2289520 polymorphism may be a factor that increases the susceptibility to oral cancer. The interactions of gene to oral cancer-related environmental risk factors have a synergetic effect that can further enhance oral cancer development. more...
- Published
- 2016
10. Development and Psychometric Evaluation of the Chinese Feeding Difficulty Index (Ch-FDI) for People with Dementia
- Author
-
Yen-Kuang Lin, Megan F. Liu, Beverly L. Roberts, Mu-Hsing Ho, Chia-Chi Chang, I-Hui Chen, and Nae-Fang Miao
- Subjects
Gerontology ,Male ,Psychometrics ,Concurrent validity ,Taiwan ,lcsh:Medicine ,Pilot Projects ,Cronbach's alpha ,Content validity ,Humans ,Translations ,lcsh:Science ,Face validity ,Aged ,Aged, 80 and over ,Multidisciplinary ,lcsh:R ,Construct validity ,Reproducibility of Results ,Feeding Behavior ,Long-Term Care ,Exploratory factor analysis ,Research Design ,Scale (social sciences) ,lcsh:Q ,Dementia ,Female ,Psychology ,Factor Analysis, Statistical ,Algorithms ,Research Article - Abstract
Aims To develop and evaluate the psychometric properties of a Chinese Feeding Difficulty Index (Ch-FDI) which assesses feeding difficulties in people with dementia (PwD). Research Design and Method Scale items were developed using literature review based on Model of Feeding Difficulty. Content validity was evaluated and items were modified by expert panel. Following translation and back-translation, the Ch-FDI was piloted on residents with dementia. The reliability was tested by inter-rater reliability and test-retest reliability. Internal reliability was established by calculating Cronbach's α coefficient. The concurrent validity was evaluated by correlating with similar scale, the Edinburgh Feeding Evaluation in Dementia (EdFED). The exploratory factor analysis (EFA) with varimax rotation and parallel analysis (PA) was performed to test construct validity. Method Participants were recruited from long-term care facilities in Taiwan. A total of 213 residents with dementia participated in this study during May, 2010 to February, 2011. Results Content validation, translation and psychometric testing were completed on the 19 items of the Ch-FDI. The translated scale was piloted on 213 residents with dementia of feeding difficulty who were recruited from eight long-term care facilities in Taiwan. The reliability was supported by the internal consistency of Cronbach's α of 0.68 and a test-retest coefficient of 0.85. The content validity, face validity, concurrent validity, and construct validity were used. Conclusions The Ch-FDI is a newly developed scale with fair psychometric properties aimed to measure feeding difficulties among residents with dementia in long-term care facilities in Taiwan. Using this reliable and valid tool can help healthcare providers to assess feeding problems of PwD and provide feeding assistance in order to promote quality of care during mealtime in long-term care facilities. more...
- Published
- 2015
11. Effects of Salivary Oxidative Markers on Edentulous Patients’ Satisfaction with Prosthetic Denture Treatments: A Pilot Study
- Author
-
Yung Kai Huang, Chia Huang Chang, Che-Tong Lin, Nae-Fang Miao, Chang-Yu Lee, Sheng-Wei Feng, Pei Huan Lin, and Shin-Han Tsai
- Subjects
Male ,Saliva ,Teeth ,Physiology ,lcsh:Medicine ,Dentistry ,Oral Health ,Pilot Projects ,Biochemistry ,Antioxidants ,0302 clinical medicine ,Surveys and Questionnaires ,Medicine and Health Sciences ,Medicine ,Public and Occupational Health ,030212 general & internal medicine ,lcsh:Science ,Prosthetics ,Multidisciplinary ,Denture, Complete ,biology ,Physics ,Dental Plaque Index ,Enzymes ,Body Fluids ,Dismutases ,Patient Satisfaction ,Physical Sciences ,Female ,Anatomy ,Mouth, Edentulous ,Periodontal Index ,Research Article ,Biotechnology ,Disabilities ,Oral Medicine ,Oxidative phosphorylation ,Superoxide dismutase ,03 medical and health sciences ,Patient satisfaction ,Humans ,Aged ,Superoxide Dismutase ,business.industry ,lcsh:R ,Biology and Life Sciences ,Proteins ,030206 dentistry ,Physical Properties ,Jaw ,Enzymology ,biology.protein ,lcsh:Q ,Medical Devices and Equipment ,business ,Digestive System ,Head ,Biomarkers - Abstract
OBJECTIVES:The purpose of this study was to assess relationships among periodontal conditions, salivary antioxidant levels, and patients' satisfaction with their prostheses. METHODS:This study was conducted at the Division of Prosthodontics, Department of Dentistry, Taipei Medical University Hospital. The periodontal condition of patients was based on an assessment of the plaque index (PI) and gingival index (GI). The pH value, flow rate, and buffer capacity of the saliva were estimated. The salivary total antioxidant status (TAS) and superoxide dismutase (SOD) level were also determined. Patients' satisfaction with prosthetic treatments was evaluated using the Chinese version of the short-form Oral Health Impact Profile (OHIP-14C). A multivariate regression model was used to determine whether patients' satisfaction with prosthetic treatment was affected by their oral health status. RESULTS:In total, 35 edentulous patients were recruited. In the Spearman correlation analysis, salivary pH (r = -0.36, p = 0.03) and the buffer ability (r = -0.48, p more...
- Published
- 2016
- Full Text
- View/download PDF
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