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Your search keyword '"Mulder, Barbara J M"' showing total 6 results
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6 results on '"Mulder, Barbara J M"'

1. Hemodynamic and metabolic characteristics associated with development of a right ventricular outflow tract pressure gradient during upright exercise

Author

van Riel, Annelieke C. M. J., primary, Systrom, David M., additional, Oliveira, Rudolf K. F., additional, Landzberg, Michael J., additional, Mulder, Barbara J. M., additional, Bouma, Berto J., additional, Maron, Bradley A., additional, Shah, Amil M., additional, Waxman, Aaron B., additional, and Opotowsky, Alexander R., additional

Published
2017
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2. Hemodynamic and metabolic characteristics associated with development of a right ventricular outflow tract pressure gradient during upright exercise.

Author

Bouma, Berto J., van Riel, Annelieke C. M. J., Mulder, Barbara J. M., Systrom, David M., Waxman, Aaron B., Oliveira, Rudolf K. F., Landzberg, Michael J., Opotowsky, Alexander R., Shah, Amil M., and Maron, Bradley A.

Subjects
HEART ventricle diseases, HEART ventricle abnormalities, LEFT heart ventricle, RIGHT heart ventricle, PATIENTS, DIAGNOSIS, THERAPEUTICS
Abstract

Background: We recently reported a novel observation that many patients with equal resting supine right ventricular(RV) and pulmonary artery(PA) systolic pressures develop an RV outflow tract(RVOT) pressure gradient during upright exercise. The current work details the characteristics of patients who develop such an RVOT gradient. Methods: We studied 294 patients (59.7±15.5 years-old, 49% male) referred for clinical invasive cardiopulmonary exercise testing, who did not have a resting RVOT pressure gradient defined by the simultaneously measured peak-to-peak difference between RV and PA systolic pressures. Results: The magnitude of RVOT gradient did not correspond to clinical or hemodynamic findings suggestive of right heart failure; rather, higher gradients were associated with favorable exercise findings. The presence of a high peak RVOT gradient (90th percentile, ≥33mmHg) was associated with male sex (70 vs. 46%, p = 0.01), younger age (43.6±17.7 vs. 61.8±13.9 years, p<0.001), lower peak right atrial pressure (5 [3–7] vs. 8 [4–12]mmHg, p<0.001), higher peak heart rate (159±19 vs. 124±26 beats per minute, p<0.001), and higher peak cardiac index (8.3±2.3 vs. 5.7±1.9 L/min/m2, p<0.001). These associations persisted when treating peak RVOT as a continuous variable and after age and sex adjustment. At peak exercise, patients with a high exercise RVOT gradient had both higher RV systolic pressure (78±11 vs. 66±17 mmHg, p<0.001) and lower PA systolic pressure (34±8 vs. 50±19 mmHg, p<0.001). Conclusions: Development of a systolic RV-PA pressure gradient during upright exercise is not associated with an adverse hemodynamic exercise response and may represent a normal physiologic finding in aerobically fit young people. [ABSTRACT FROM AUTHOR]

Published
2017
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4. The Ambiguous Role of NKX2-5 Mutations in Thyroid Dysgenesis

Author

van Engelen, Klaartje, primary, Mommersteeg, Mathilda T. M., additional, Baars, Marieke J. H., additional, Lam, Jan, additional, Ilgun, Aho, additional, van Trotsenburg, A. S. Paul, additional, Smets, Anne M. J. B., additional, Christoffels, Vincent M., additional, Mulder, Barbara J. M., additional, and Postma, Alex V., additional

Published
2012
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6. Inflammation Aggravates Disease Severity in Marfan Syndrome Patients

Author

Radonic, Teodora, primary, de Witte, Piet, additional, Groenink, Maarten, additional, de Waard, Vivian, additional, Lutter, Rene, additional, van Eijk, Marco, additional, Jansen, Marnix, additional, Timmermans, Janneke, additional, Kempers, Marlies, additional, Scholte, Arthur J., additional, Hilhorst-Hofstee, Yvonne, additional, van den Berg, Maarten P., additional, van Tintelen, J. Peter, additional, Pals, Gerard, additional, Baars, Marieke J. H., additional, Mulder, Barbara J. M., additional, and Zwinderman, Aeilko H., additional

Published
2012
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