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3. Effect of vitamin D supplementation on cardiometabolic risks and health-related quality of life among urban premenopausal women in a tropical country--a randomized controlled trial.

Author

Mazliza Ramly, Moy Foong Ming, Karuthan Chinna, Suhaili Suboh, and Rokiah Pendek

Subjects
Medicine, Science
Abstract

BACKGROUND: Many observational studies linked vitamin D to cardiometabolic risks besides its pivotal role in musculoskeletal diseases, but evidence from trials is lacking and inconsistent. AIM: To determine whether Vitamin D supplementation in urban premenopausal women with vitamin D deficiency can improve cardiometabolic risks and health-related quality of life (HRQOL). DESIGN: A double-blind randomized controlled trial was conducted in Kuala Lumpur, Malaysia. A total of 192 vitamin D deficient (0.05) between two groups. There was a small but significant improvement in HRQOL in the components of vitality (mean difference: 5.041; 95% CI: 0.709 to 9.374) and mental component score (mean difference: 2.951; 95% CI: 0.573 to 5.329) in the intervention group compared to placebo group. CONCLUSION: Large and less frequent dosage vitamin D supplementation was safe and effective in the achievement of vitamin D sufficiency. However, there was no improvement in measured cardiometabolic risk factors in premenopausal women. Conversely vitamin D supplementation improves some components of HRQOL. TRIAL REGISTRATION: Australian New Zealand Clinical Trial Registry ACTRN12612000452897.

Published
2014
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6. Effect of vitamin D supplementation on cardiometabolic risks and health-related quality of life among urban premenopausal women in a tropical country--a randomized controlled trial

Author

Moy Foong Ming, Suhaili Suboh, Mazliza Ramly, Karuthan Chinna, and Rokiah Pendek

Subjects
Adult, Risk, medicine.medical_specialty, Heart Diseases, Epidemiology, lcsh:Medicine, Placebo, vitamin D deficiency, law.invention, Endocrinology, Randomized controlled trial, Quality of life, law, Internal medicine, Vitamin D and neurology, Medicine and Health Sciences, Medicine, Humans, Public and Occupational Health, Vitamin D, lcsh:Science, Nutrition, Tropical Climate, Multidisciplinary, business.industry, Nutritional Deficiencies, lcsh:R, Malaysia, Biology and Life Sciences, Middle Aged, medicine.disease, Vitamin D Deficiency, Clinical trial, Patient Outcome Assessment, Blood pressure, Premenopause, Metabolic Disorders, Dietary Supplements, Physical therapy, Quality of Life, Observational study, Female, lcsh:Q, business, Research Article
Abstract

Background Many observational studies linked vitamin D to cardiometabolic risks besides its pivotal role in musculoskeletal diseases, but evidence from trials is lacking and inconsistent. Aim To determine whether Vitamin D supplementation in urban premenopausal women with vitamin D deficiency can improve cardiometabolic risks and health-related quality of life (HRQOL). Design A double-blind randomized controlled trial was conducted in Kuala Lumpur, Malaysia. A total of 192 vitamin D deficient (0.05) between two groups. There was a small but significant improvement in HRQOL in the components of vitality (mean difference: 5.041; 95% CI: 0.709 to 9.374) and mental component score (mean difference: 2.951; 95% CI: 0.573 to 5.329) in the intervention group compared to placebo group. Conclusion Large and less frequent dosage vitamin D supplementation was safe and effective in the achievement of vitamin D sufficiency. However, there was no improvement in measured cardiometabolic risk factors in premenopausal women. Conversely vitamin D supplementation improves some components of HRQOL. Trial Registration Australian New Zealand Clinical Trial Registry ACTRN12612000452897

Published
2014

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