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3 results on '"Minguang Zhang"'

1. Robotic versus open radical cystectomy: an updated systematic review and meta-analysis.

Author

Leilei Xia, Xianjin Wang, Tianyuan Xu, Xiaohua Zhang, Zhaowei Zhu, Liang Qin, Xiang Zhang, Chen Fang, Minguang Zhang, Shan Zhong, and Zhoujun Shen

Subjects
Medicine, Science
Abstract

To critically review the currently available evidence of studies comparing robot-assisted radical cystectomy (RARC) with open radical cystectomy (ORC).A comprehensive review of the literature from Pubmed, Web of Science and Scopus was performed in April 2014. All relevant studies comparing RARC with ORC were included for further screening. A pooled meta-analysis of all comparative studies was performed and publication bias was assessed by a funnel plot.Nineteen studies were included for the analysis, including a total of 1779 patients (787 patients in the RARC group and 992 patients in the ORC group). Although RARC was associated with longer operative time (p

Published
2015
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2. Robotic versus open radical cystectomy: an updated systematic review and meta-analysis

Author

Zhaowei Zhu, Xiaohua Zhang, Xiang Zhang, Zhoujun Shen, Shan Zhong, Tianyuan Xu, Chen Fang, Minguang Zhang, Leilei Xia, Liang Qin, and Xianjin Wang

Subjects
Male, medicine.medical_specialty, Funnel plot, Blood transfusion, medicine.medical_treatment, lcsh:Medicine, Cystectomy, law.invention, Randomized controlled trial, law, medicine, Humans, lcsh:Science, Multidisciplinary, business.industry, lcsh:R, Publication bias, Perioperative, Robotics, Middle Aged, Surgery, Meta-analysis, Female, lcsh:Q, business, Complication, Research Article
Abstract

Objective To critically review the currently available evidence of studies comparing robot-assisted radical cystectomy (RARC) with open radical cystectomy (ORC). Methods A comprehensive review of the literature from Pubmed, Web of Science and Scopus was performed in April 2014. All relevant studies comparing RARC with ORC were included for further screening. A pooled meta-analysis of all comparative studies was performed and publication bias was assessed by a funnel plot. Results Nineteen studies were included for the analysis, including a total of 1779 patients (787 patients in the RARC group and 992 patients in the ORC group). Although RARC was associated with longer operative time (p

Published
2015

3. Theranostic Studies of Human Sodium Iodide Symporter Imaging and Therapy Using 188Re: A Human Glioma Study in Mice

Author

Minguang Zhang, Yun Xi, Ying Miao, Shuo Shi, Rui Guo, Biao Li, Yufei Ma, and Sheng Liang

Subjects
Sodium-iodide symporter, Diagnostic Imaging, Human glioma, Genetic enhancement, Genetic Vectors, Cancer Treatment, lcsh:Medicine, Radiation Therapy, Diagnostic Radiology, Mice, Diagnostic Medicine, Glioma, Medicine and Health Sciences, Cancer Detection and Diagnosis, Tumor Cells, Cultured, Medicine, Animals, Humans, Radionuclide imaging, Tissue Distribution, lcsh:Science, Molecular Biology Techniques, Radionuclide Imaging, neoplasms, Molecular Biology, Multidisciplinary, Symporters, business.industry, Brain Neoplasms, Thyroid, lcsh:R, Biology and Life Sciences, Gene Therapy, Genetic Therapy, medicine.disease, Xenograft Model Antitumor Assays, Cancer treatment, nervous system diseases, medicine.anatomical_structure, Rhenium, Oncology, Cancer research, lcsh:Q, Nuclear medicine, business, Cancer Screening, Research Article
Abstract

Objective To investigate the role of 188Re in human sodium iodide symporter (hNIS) theranostic gene-mediated human glioma imaging and therapy in model mice. Methods The human glioma cell line U87 was transfected with recombinant lentivirus encoding the hNIS gene under the control of cytomegalovirus promoter (U87-hNIS). The uptake and efflux of 188Re were determined after incubating the cells with 188Re. 188Re uptake experiments in the presence of various concentrations of sodium perchlorate were carried out. In vitro cell killing tests with 188Re were performed. U87-hNIS mediated 188Re distribution, imaging and therapy in nude mice were also tested. Results U87-hNIS cell line was successfully established. The uptake of 188Re in U87-hNIS cells increased up to 26-fold compared to control cells, but was released rapidly with a half-life of approximately 4 minutes. Sodium perchlorate reduced hNIS-mediated 188Re uptake to levels of control cell lines. U87-hNIS cells were selectively killed following exposure to 188Re, with a survival of 21.4%, while control cells had a survival of 92.1%. Unlike in vitro studies, U87-hNIS tumor showed a markedly increased 188Re retention even 48 hours after 188Re injection. In the therapy study, there was a significant difference in tumor size between U87-hNIS mice (317±67 mm3) and control mice (861±153 mm3) treated with 188Re for 4 weeks (P

Published
2014

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