6 results on '"Min Ai"'
Search Results
2. Glycyrrhiza uralensis promote the metabolism of toxic components of Aconitum carmichaeli by CYP3A and alleviate the development of chronic heart failure.
- Author
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Lulu Ni, Ping Miao, Jian Jiang, Fang Wan, Jiangan Li, Min Ai, Lingzhong Kong, and Su Tu
- Subjects
Medicine ,Science - Abstract
Aconitum, as "the first drug of choice for invigorating Yang and saving lives", has been widely used for the treatment of heart failure. However, toxic components of Aconitum can easily lead to serious arrhythmia, even death (Y. CT., 2009; Zhang XM., 2018). In this study, a High Performance Liquid Chromatography (HPLC) method for the determination of aconitine (AC), mesaconitine (MA) and hypaconitine (HA) was established; The effect of Glycyrrhiza on CYP3A1 / 2 mRNA expression was detected by RT-PCR; SD rats were given Aconitum and compatibility of Glycyrrhizae and Aconitum by gavage respectively, the blood concentration of toxic components were determined by LC-MS / MS; The CHF rat model was established by intraperitoneal injection of adriamycin (2.5 mg / kg), and were randomly divided into model, Aconitum, the compatibility of Glycyrrhizae and Aconitum and Captopril group, 5 mice/group. After 4 weeks of gavage, the corresponding indexes were detected by ELISA and HPLC. The results showed that Ketoconazole significantly inhibited the metabolites of AC, MA and HA; Glycyrrhiza induced CYP3A gene expression; The level of ALD in the compatibility of Glycyrrhizae and Aconitum group was significantly lower than that in Aconitum group. After intervention with the compatibility of Glycyrrhizae and Aconitum, ATP increased, ADP decreased significantly. In conclusion, we found Glycyrrhiza promoted the metabolism of toxic components of Aconitum by up regulating the expression of CYP3A, and reduced the content of BNP, Ang II and ALD, improved the energy metabolism disorder of myocardium, alleviated the development of CHF. more...
- Published
- 2022
- Full Text
- View/download PDF
Catalog
3. Correction: Cholecystectomy can increase the risk of colorectal cancer: A meta-analysis of 10 cohort studies.
- Author
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Yong Zhang, Hao Liu, Li Li, Min Ai, Zheng Gong, Yong He, Yunlong Dong, Shuanglan Xu, Jun Wang, Bo Jin, Jianping Liu, and Zhaowei Teng
- Subjects
Medicine ,Science - Abstract
[This corrects the article DOI: 10.1371/journal.pone.0181852.].
- Published
- 2018
- Full Text
- View/download PDF
4. Cholecystectomy can increase the risk of colorectal cancer: A meta-analysis of 10 cohort studies.
- Author
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Yong Zhang, Hao Liu, Li Li, Min Ai, Zheng Gong, Yong He, Yunlong Dong, Shuanglan Xu, Jun Wang, Bo Jin, Jianping Liu, and Zhaowei Teng
- Subjects
Medicine ,Science - Abstract
This study aimed to elucidate the effects of cholecystectomy on the risk of colorectal cancer (CRC) by conducting a meta-analysis of 10 cohort studies.The eligible cohort studies were selected by searching the PubMed and EMBASE databases from their origination to June 30, 2016, as well as by consulting the reference lists of the selected articles. Two authors individually collected the data from the 10 papers. When the data showed marked heterogeneity, we used a random-effects model to estimate the overall pooled risk; otherwise, a fixed effects model was employed.The final analysis included ten cohort studies. According to the Newcastle-Ottawa Scale (NOS), nine papers were considered high quality. After the data of these 9 studies were combined, an increased risk of CRC was found among the individuals who had undergone cholecystectomy (risk ratio (RR) 1.22; 95% confidence interval (CI) 1.08-1.38). In addition, we also found a promising increased risk for colon cancer (CC) (RR 1.30, 95% CI 1.07-1.58), but no relationship between cholecystectomy and rectum cancer (RC) (RR 1.09; 95% CI 0.89-1.34) was observed. Additionally, in the sub-group analysis of the tumor location in the colon, a positive risk for ascending colon cancer (ACC) was found (RR 1.18, 95% CI 1.11-1.26). After combining the ACC, transverse colon cancer (TCC), sigmoid colon cancer (SCC) and descending colon cancer (DCC) patients, we found a positive relationship with cholecystectomy (RR 1.18, 95% CI 1.11-1.26). Furthermore, after combining the ACC and DCC patients, we also found a positive relationship with cholecystectomy (RR 1.28; 95% CI 1.11-1.26) in the sub-group analysis. In an additional sub-group analysis of patients from Western countries, there was a positive relationship between cholecystectomy and the risk of CRC (RR 1.20; 95% CI 1.05-1.36). Furthermore, a positive relationship between female gender and CRC was also found (RR 1.17; 95% CI 1.03-1.34). However, there was no relationship between gender and CC or RC. Furthermore, no publication bias was observed, and the sensitivity analysis indicated stable results.This meta-analysis of 10 cohort studies revealed that cholecystectomy is associated with an increased risk for CRC, CC and ACC, particularly in Western countries. No relationship between cholecystectomy and RC was observed. There was no relationship between gender and either CC or RC, but a positive relationship between female gender and CRC was observed. more...
- Published
- 2017
- Full Text
- View/download PDF
5. Correction: Cholecystectomy can increase the risk of colorectal cancer: A meta-analysis of 10 cohort studies
- Author
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Jun Wang, Yong He, Min Ai, Zhaowei Teng, Yunlong Dong, Shuanglan Xu, Jianping Liu, Bo Jin, Hao Liu, Zheng Gong, Li Li, and Yong Zhang
- Subjects
Oncology ,medicine.medical_specialty ,Multidisciplinary ,business.industry ,Colorectal cancer ,medicine.medical_treatment ,lcsh:R ,MEDLINE ,lcsh:Medicine ,medicine.disease ,Text mining ,Internal medicine ,Meta-analysis ,Medicine ,Cholecystectomy ,lcsh:Q ,business ,lcsh:Science ,Cohort study - Abstract
[This corrects the article DOI: 10.1371/journal.pone.0181852.].
- Published
- 2018
6. Cholecystectomy can increase the risk of colorectal cancer: A meta-analysis of 10 cohort studies
- Author
-
Jun Wang, Jianping Liu, Shuanglan Xu, Min Ai, Zhaowei Teng, Yunlong Dong, Yong He, Zheng Gong, Yong Zhang, Hao Liu, Bo Jin, and Li Li
- Subjects
Oncology ,Colorectal cancer ,medicine.medical_treatment ,lcsh:Medicine ,Gastroenterology ,Cohort Studies ,Database and Informatics Methods ,Mathematical and Statistical Techniques ,0302 clinical medicine ,Risk Factors ,Medicine and Health Sciences ,Medicine ,Database Searching ,lcsh:Science ,Multidisciplinary ,Laparoscopic Cholecystectomy ,medicine.anatomical_structure ,Research Design ,030220 oncology & carcinogenesis ,Meta-analysis ,Physical Sciences ,030211 gastroenterology & hepatology ,Anatomy ,Colorectal Neoplasms ,Statistics (Mathematics) ,Research Article ,Cohort study ,medicine.medical_specialty ,Colon ,Rectum ,Surgical and Invasive Medical Procedures ,Research and Analysis Methods ,Carcinomas ,Digestive System Procedures ,03 medical and health sciences ,Internal medicine ,Humans ,Cholecystectomy ,Statistical Methods ,Colorectal Cancer ,business.industry ,lcsh:R ,Cancers and Neoplasms ,Biology and Life Sciences ,Correction ,Cancer ,medicine.disease ,Confidence interval ,Gastrointestinal Tract ,Relative risk ,Laparoscopy ,lcsh:Q ,business ,Digestive System ,Mathematics ,Meta-Analysis - Abstract
Objective This study aimed to elucidate the effects of cholecystectomy on the risk of colorectal cancer (CRC) by conducting a meta-analysis of 10 cohort studies. Methods The eligible cohort studies were selected by searching the PubMed and EMBASE databases from their origination to June 30, 2016, as well as by consulting the reference lists of the selected articles. Two authors individually collected the data from the 10 papers. When the data showed marked heterogeneity, we used a random-effects model to estimate the overall pooled risk; otherwise, a fixed effects model was employed. Results The final analysis included ten cohort studies. According to the Newcastle-Ottawa Scale (NOS), nine papers were considered high quality. After the data of these 9 studies were combined, an increased risk of CRC was found among the individuals who had undergone cholecystectomy (risk ratio (RR) 1.22; 95% confidence interval (CI) 1.08–1.38). In addition, we also found a promising increased risk for colon cancer (CC) (RR 1.30, 95% CI 1.07–1.58), but no relationship between cholecystectomy and rectum cancer (RC) (RR 1.09; 95% CI 0.89–1.34) was observed. Additionally, in the sub-group analysis of the tumor location in the colon, a positive risk for ascending colon cancer (ACC) was found (RR 1.18, 95% CI 1.11–1.26). After combining the ACC, transverse colon cancer (TCC), sigmoid colon cancer (SCC) and descending colon cancer (DCC) patients, we found a positive relationship with cholecystectomy (RR 1.18, 95% CI 1.11–1.26). Furthermore, after combining the ACC and DCC patients, we also found a positive relationship with cholecystectomy (RR 1.28; 95% CI 1.11–1.26) in the sub-group analysis. In an additional sub-group analysis of patients from Western countries, there was a positive relationship between cholecystectomy and the risk of CRC (RR 1.20; 95% CI 1.05–1.36). Furthermore, a positive relationship between female gender and CRC was also found (RR 1.17; 95% CI 1.03–1.34). However, there was no relationship between gender and CC or RC. Furthermore, no publication bias was observed, and the sensitivity analysis indicated stable results. Conclusions This meta-analysis of 10 cohort studies revealed that cholecystectomy is associated with an increased risk for CRC, CC and ACC, particularly in Western countries. No relationship between cholecystectomy and RC was observed. There was no relationship between gender and either CC or RC, but a positive relationship between female gender and CRC was observed. more...
- Published
- 2017
- Full Text
- View/download PDF
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